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</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="International nonproprietary name (INN): Zolmitriptan">Zolmitriptan</span></caption><tbody><tr><td colspan="2" class="infobox-image"><span class="dark_mode_safe" typeof="mw:File"></span></td></tr><tr><td colspan="2" class="infobox-image"><span class="dark_mode_safe" typeof="mw:File"></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="Drug_nomenclature#Trade_names" title="Drug nomenclature">Trade names</a></th><td class="infobox-data">Zomig, others</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">Other names</th><td class="infobox-data">BW-311C90; BW311C90; 311C90; BW-311-C-90; ML-004; ML004; [(4<i>S</i>)-2-Oxo-1,3-oxazolidin-4-yl]methyl-<i>N</i>,<i>N</i>-dimethyltryptamine; [(4<i>S</i>)-2-Oxo-1,3-oxazolidin-4-yl]methyl-DMT</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="American_Society_of_Health-System_Pharmacists" title="American Society of Health-System Pharmacists">AHFS</a>/<a href="Drugs.com" title="Drugs.com">Drugs.com</a></th><td class="infobox-data"><span title="www.drugs.com"><a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/zolmitriptan.html">Monograph</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="MedlinePlus" title="MedlinePlus">MedlinePlus</a></th><td class="infobox-data"><span title="medlineplus.gov"><a rel="nofollow" class="external text" href="https://medlineplus.gov/druginfo/meds/a601129.html">a601129</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">License data</a></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r1126788409">
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<ul><li><small><abbr class="country-name" title="United States">US</abbr></small> <a href="DailyMed" title="DailyMed">DailyMed</a>: <span title="dailymed.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Zolmitriptan">Zolmitriptan</a></span></li></ul></div>
</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="Pregnancy_category" title="Pregnancy category">Pregnancy<br>category</a></th><td class="infobox-data"><div class="plainlist">
<ul><li><small><abbr class="country-name" title="Australia">AU</abbr>:</small> B3</li>
</ul>
</div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="Route_of_administration" title="Route of administration">Routes of<br>administration</a></th><td class="infobox-data"><a href="Oral_administration" title="Oral administration">By mouth</a>, <a href="Nasal_administration" title="Nasal administration">intranasal</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="Drug_class" title="Drug class">Drug class</a></th><td class="infobox-data"><a href="Serotonin" title="Serotonin">Serotonin</a> <a href="5-HT1B_receptor" title="5-HT1B receptor">5-HT<sub>1B</sub></a>, <a href="5-HT1D_receptor" title="5-HT1D receptor">5-HT<sub>1D</sub></a>, <a href="5-HT1E_receptor" title="5-HT1E receptor">5-HT<sub>1E</sub></a>, and <a href="5-HT1F_receptor" title="5-HT1F receptor">5-HT<sub>1F</sub> receptor</a> <a href="Agonist" title="Agonist">agonist</a>; <a href="Antimigraine_agent" class="mw-redirect" title="Antimigraine agent">Antimigraine agent</a>; <a href="Triptan" title="Triptan">Triptan</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="Anatomical_Therapeutic_Chemical_Classification_System" title="Anatomical Therapeutic Chemical Classification System">ATC code</a></th><td class="infobox-data"><div class="plainlist"><ul><li><a href="ATC_code_N02" title="ATC code N02">N02CC03</a> (<span title="www.whocc.no"><a rel="nofollow" class="external text" href="https://www.whocc.no/atc_ddd_index/?code=N02CC03">WHO</a></span>) </li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Legal status</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">Legal status</a></th><td class="infobox-data"><div class="plainlist">
<ul><li><small><abbr class="country-name" title="Canada">CA</abbr></small>: <a href="Prescription_drug" title="Prescription drug"> ℞-only</a><sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></li>
<li><small><abbr class="country-name" title="United States">US</abbr>:</small> <a href="Prescription_drug" title="Prescription drug">℞-only</a></li></ul></div>
</td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;"><a href="Pharmacokinetics" title="Pharmacokinetics">Pharmacokinetic</a> data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="Bioavailability" title="Bioavailability">Bioavailability</a></th><td class="infobox-data"><a href="Oral_administration" title="Oral administration">Oral</a>: 40%<sup id="cite_ref-DrugBank_2-0" class="reference"><a href="#cite_note-DrugBank-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="Plasma_protein_binding" title="Plasma protein binding">Protein binding</a></th><td class="infobox-data">25%<sup id="cite_ref-DrugBank_2-1" class="reference"><a href="#cite_note-DrugBank-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="Drug_metabolism" title="Drug metabolism">Metabolism</a></th><td class="infobox-data"><a href="Liver" title="Liver">Liver</a> (<a href="CYP1A2" title="CYP1A2">CYP1A2</a>-mediated, to active metabolite; also <a href="Monoamine_oxidase_A" title="Monoamine oxidase A"><abbr title="monoamine oxidase A">MAO-A</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip monoamine oxidase A</span>)<sup id="cite_ref-DrugBank_2-9" class="reference"><a href="#cite_note-DrugBank-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Yu2008_3-1" class="reference"><a href="#cite_note-Yu2008-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="Metabolite" title="Metabolite">Metabolites</a></th><td class="infobox-data">• <i>N</i>-Desmethylzolmitriptan<sup id="cite_ref-DrugBank_2-2" class="reference"><a href="#cite_note-DrugBank-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Yu2008_3-0" class="reference"><a href="#cite_note-Yu2008-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><br>• Zolmitriptan <i>N</i>-oxide<sup id="cite_ref-DrugBank_2-3" class="reference"><a href="#cite_note-DrugBank-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><br>• Indole acetic acid derivative<sup id="cite_ref-DrugBank_2-4" class="reference"><a href="#cite_note-DrugBank-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="Biological_half-life" title="Biological half-life">Elimination <span class="nowrap">half-life</span></a></th><td class="infobox-data">Zolmitriptan: 3<span class="nowrap"> </span>hours<sup id="cite_ref-DrugBank_2-5" class="reference"><a href="#cite_note-DrugBank-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><br><i>N</i>-Desmethylzolmitriptan: 3.5<span class="nowrap"> </span>hours<sup id="cite_ref-DrugBank_2-6" class="reference"><a href="#cite_note-DrugBank-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="Excretion" title="Excretion">Excretion</a></th><td class="infobox-data"><a href="Urine" title="Urine">Urine</a>: ~65%<sup id="cite_ref-DrugBank_2-7" class="reference"><a href="#cite_note-DrugBank-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><br><a href="Feces" title="Feces">Feces</a>: ~30%<sup id="cite_ref-DrugBank_2-8" class="reference"><a href="#cite_note-DrugBank-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Identifiers</th></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;">
<div style="line-height: 1.6em; font-weight: bold;"><div><a href="IUPAC_nomenclature_of_chemistry" title="IUPAC nomenclature of chemistry">IUPAC name</a></div></div>
<ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all; text-align:left; padding-left:1.5em; text-indent:-1.5em;"><li style="line-height: inherit; margin: 0"><div style="font-size: 97%;">(<i>S</i>)-4-({3-[2-(Dimethylamino)ethyl]-1<i>H</i>-indol-5-yl}methyl)-1,3-oxazolidin-2-one</div></li></ul>
</div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="CAS_Registry_Number" title="CAS Registry Number">CAS Number</a></th><td class="infobox-data"><div class="plainlist"><ul><li><span title="commonchemistry.cas.org"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=139264-17-8">139264-17-8</a></span><sup> <span typeof="mw:File"><span></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="PubChem#CID" title="PubChem">PubChem</a> <span style="font-weight:normal"><abbr title="Compound ID">CID</abbr></span></th><td class="infobox-data"><div class="plainlist"><ul><li><span title="pubchem.ncbi.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/60857">60857</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="Guide_to_Pharmacology" title="Guide to Pharmacology">IUPHAR/BPS</a></th><td class="infobox-data"><div class="plainlist"><ul><li><span title="www.guidetopharmacology.org"><a rel="nofollow" class="external text" href="https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=60">60</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="DrugBank" title="DrugBank">DrugBank</a></th><td class="infobox-data"><div class="plainlist"><ul><li><span title="www.drugbank.ca"><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB00315">DB00315</a></span><sup> <span typeof="mw:File"><span></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="ChemSpider" title="ChemSpider">ChemSpider</a></th><td class="infobox-data"><div class="plainlist"><ul><li><span title="www.chemspider.com"><a rel="nofollow" class="external text" href="https://www.chemspider.com/Chemical-Structure.54844.html">54844</a></span><sup> <span typeof="mw:File"><span></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="Unique_Ingredient_Identifier" title="Unique Ingredient Identifier">UNII</a></th><td class="infobox-data"><div class="plainlist"><ul><li><span title="precision.fda.gov"><a rel="nofollow" class="external text" href="https://precision.fda.gov/uniisearch/srs/unii/2FS66TH3YW">2FS66TH3YW</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="KEGG" title="KEGG">KEGG</a></th><td class="infobox-data"><div class="plainlist"><ul><li><span title="www.kegg.jp"><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/D00415">D00415</a></span><sup> <span typeof="mw:File"><span></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="ChEBI" title="ChEBI">ChEBI</a></th><td class="infobox-data"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:10124">CHEBI:10124</a></span><sup> <span typeof="mw:File"><span></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="ChEMBL" title="ChEMBL">ChEMBL</a></th><td class="infobox-data"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chembl/explore/compound/ChEMBL1185">ChEMBL1185</a></span><sup> <span typeof="mw:File"><span></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="CompTox_Chemicals_Dashboard" title="CompTox Chemicals Dashboard">CompTox Dashboard</a> <span style="font-weight:normal">(<abbr title="U.S. Environmental Protection Agency">EPA</abbr>)</span></th><td class="infobox-data"><div class="plainlist"><ul><li><span title="comptox.epa.gov"><a rel="nofollow" class="external text" href="https://comptox.epa.gov/dashboard/chemical/details/DTXSID8045933">DTXSID8045933</a> </span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="ECHA_InfoCard" class="mw-redirect" title="ECHA InfoCard"><span title="echa.europa.eu">ECHA InfoCard</span></a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://echa.europa.eu/substance-information/-/substanceinfo/100.158.186">100.158.186</a> </td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Chemical and physical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="Chemical_formula" title="Chemical formula">Formula</a></th><td class="infobox-data"><span title="Carbon">C</span><sub>16</sub><span title="Hydrogen">H</span><sub>21</sub><span title="Nitrogen">N</span><sub>3</sub><span title="Oxygen">O</span><sub>2</sub></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="Molar_mass" title="Molar mass">Molar mass</a></th><td class="infobox-data"><span class="nowrap">287.363</span> g·mol<sup>−1</sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">3D model (<a href="JSmol" class="mw-redirect" title="JSmol">JSmol</a>)</th><td class="infobox-data"><div class="plainlist"><ul><li><span title="chemapps.stolaf.edu (3D interactive model)"><a rel="nofollow" class="external text" href="https://chemapps.stolaf.edu/jmol/jmol.php?model=O%3DC1OC%5BC%40%40H%5D%28N1%29Cc2ccc3c%28c2%29c%28c%5BnH%5D3%29CCN%28C%29C">Interactive image</a></span></li></ul></div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;">
<div style="line-height: 1.6em; font-weight: bold;"><div><a href="Simplified_molecular-input_line-entry_system" class="mw-redirect" title="Simplified molecular-input line-entry system">SMILES</a></div></div>
<ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">O=C1OC[C@@H](N1)Cc2ccc3c(c2)c(c[nH]3)CCN(C)C</div></li></ul>
</div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;">
<div style="line-height: 1.6em; font-weight: bold;"><div><a href="International_Chemical_Identifier" title="International Chemical Identifier">InChI</a></div></div>
<ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">InChI=1S/C16H21N3O2/c1-19(2)6-5-12-9-17-15-4-3-11(8-14(12)15)7-13-10-21-16(20)18-13/h3-4,8-9,13,17H,5-7,10H2,1-2H3,(H,18,20)/t13-/m0/s1<sup> <span typeof="mw:File"><span></span></span><span style="display:none">Y</span></sup></div></li><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">Key:ULSDMUVEXKOYBU-ZDUSSCGKSA-N<sup> <span typeof="mw:File"><span></span></span><span style="display:none">Y</span></sup></div></li></ul>
</div></td></tr><tr><td colspan="2" class="infobox-below"><style data-mw-deduplicate="TemplateStyles:r886047488">
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<p><b>Zolmitriptan</b>, sold under the brand name <b>Zomig</b> among others, is a <a href="Serotonergic_drug" class="mw-redirect" title="Serotonergic drug">serotonergic</a> <a href="Medication" title="Medication">medication</a> which is used in the acute treatment of <a href="Migraine" title="Migraine">migraine</a> attacks with or without <a href="Aura_(symptom)" title="Aura (symptom)">aura</a> and <a href="Cluster_headache" title="Cluster headache">cluster headaches</a>.<sup id="cite_ref-Zolmig-Label_4-0" class="reference"><a href="#cite_note-Zolmig-Label-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> It is taken <a href="Oral_administration" title="Oral administration">by mouth</a> as a <a href="Swallowing" title="Swallowing">swallowed</a> or <a href="Orally_disintegrating_tablet" title="Orally disintegrating tablet">disintegrating</a> <a href="Tablet_(pharmacy)" title="Tablet (pharmacy)">tablet</a> or as a <a href="Nasal_spray" title="Nasal spray">nasal spray</a>.<sup id="cite_ref-Zolmig-Label_4-1" class="reference"><a href="#cite_note-Zolmig-Label-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>
</p><p><a href="Side_effect" title="Side effect">Side effects</a> include tightness in the neck or throat, <a href="Orofacial_pain" title="Orofacial pain">jaw pain</a>, <a href="Dizziness" title="Dizziness">dizziness</a>, <a href="Paresthesia" title="Paresthesia">paresthesia</a>, <a href="Asthenia" class="mw-redirect" title="Asthenia">asthenia</a>, <a href="Somnolence" title="Somnolence">somnolence</a>, warm/cold sensations, <a href="Nausea" title="Nausea">nausea</a>, <a href="Chest_pressure" class="mw-redirect" title="Chest pressure">chest pressure</a>, and <a href="Dry_mouth" class="mw-redirect" title="Dry mouth">dry mouth</a>.<sup id="cite_ref-Zolmig-Label_4-2" class="reference"><a href="#cite_note-Zolmig-Label-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> The drug acts as a <a href="Binding_selectivity" title="Binding selectivity">selective</a> <a href="Serotonin" title="Serotonin">serotonin</a> <a href="5-HT1B_receptor" title="5-HT1B receptor">5-HT<sub>1B</sub></a> and <a href="5-HT1D_receptor" title="5-HT1D receptor">5-HT<sub>1D</sub> receptor</a> <a href="Agonist" title="Agonist">agonist</a>.<sup id="cite_ref-Zolmig-Label_4-3" class="reference"><a href="#cite_note-Zolmig-Label-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> <a href="Chemical_structure" title="Chemical structure">Structurally</a>, it is a <a href="Triptan" title="Triptan">triptan</a> and a <a href="Substituted_tryptamine" title="Substituted tryptamine">tryptamine</a> <a href="Chemical_derivative" class="mw-redirect" title="Chemical derivative">derivative</a>.<sup id="cite_ref-Zolmig-Label_4-4" class="reference"><a href="#cite_note-Zolmig-Label-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-PubChem_5-0" class="reference"><a href="#cite_note-PubChem-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup>
</p><p>It was <a href="Patent" title="Patent">patented</a> in 1990 and was approved for medical use in 1997.<sup id="cite_ref-Fis2006_6-0" class="reference"><a href="#cite_note-Fis2006-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Zolmig-Label_4-5" class="reference"><a href="#cite_note-Zolmig-Label-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>
</p>
<meta property="mw:PageProp/toc">
<div class="mw-heading mw-heading2"><h2 id="Medical_uses">Medical uses</h2></div>
<div class="mw-heading mw-heading3"><h3 id="Migraine">Migraine</h3></div>
<p>Zolmitriptan is used for the acute treatment of <a href="Migraine" title="Migraine">migraines</a> with or without <a href="Aura_(symptom)" title="Aura (symptom)">aura</a> in adults.<sup id="cite_ref-Zolmig-Label_4-6" class="reference"><a href="#cite_note-Zolmig-Label-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> It is not intended for the <a href="Prophylaxis" class="mw-redirect" title="Prophylaxis">prophylactic</a> therapy of migraine or for use in the management of <a href="Hemiplegic_migraine" title="Hemiplegic migraine">hemiplegic</a> or <a href="Basilar_migraine" class="mw-redirect" title="Basilar migraine">basilar migraine</a>.<sup id="cite_ref-Zolmig-Label_4-7" class="reference"><a href="#cite_note-Zolmig-Label-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading3"><h3 id="Off-label_uses">Off-label uses</h3></div>
<ul><li>Acute treatment of <a href="Cluster_headache" title="Cluster headache">cluster headaches</a>—Level A recommendation from the American Academy of Neurology<sup id="cite_ref-statspe_7-0" class="reference"><a href="#cite_note-statspe-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup></li>
<li>Acute treatment of <a href="Menstrual_migraine" title="Menstrual migraine">menstrual migraine</a><sup id="cite_ref-statspe_7-1" class="reference"><a href="#cite_note-statspe-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup></li></ul>
<div class="mw-heading mw-heading3"><h3 id="Available_forms">Available forms</h3></div>
<p>Zolmitriptan is available as a <a href="Swallowing" title="Swallowing">swallowed</a> <a href="Tablet_(pharmacy)" title="Tablet (pharmacy)">tablet</a>, an <a href="Orally_disintegrating_tablet" title="Orally disintegrating tablet">orally disintegrating tablet</a>, and as a <a href="Nasal_spray" title="Nasal spray">nasal spray</a>, in doses of 2.5 and 5<span class="nowrap"> </span>mg. People who get migraines from <a href="Aspartame" title="Aspartame">aspartame</a> should not use the disintegrating tablet (Zomig ZMT) as it contains aspartame.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup>
</p><p>A 2014 <a href="Cochrane_review" class="mw-redirect" title="Cochrane review">Cochrane review</a> has shown that zolmitriptan 5<span class="nowrap"> </span>mg nasal spray was significantly more effective than the 5<span class="nowrap"> </span>mg oral tablet.<sup id="cite_ref-BirdDerryMoore2014_9-0" class="reference"><a href="#cite_note-BirdDerryMoore2014-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Contraindications">Contraindications</h2></div>
<p>Zolmitriptan is contraindicated in patients with cerebrovascular or cardiovascular disease because <a href="Serotonin" title="Serotonin">serotonin</a> <a href="5-HT1B_receptor" title="5-HT1B receptor">5-HT<sub>1B</sub> receptors</a> are present in coronary arteries. Such conditions include, but are not limited to, coronary artery disease, stroke, and peripheral vascular disease.<sup id="cite_ref-statspe_7-2" class="reference"><a href="#cite_note-statspe-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> It is also contraindicated in <a href="Hemiplegic_migraine" title="Hemiplegic migraine">hemiplegic migraine</a>.<sup id="cite_ref-statspe_7-3" class="reference"><a href="#cite_note-statspe-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Side_effects">Side effects</h2></div>
<p><a href="Side_effect" title="Side effect">Side effects</a> include <a href="Neck" title="Neck">neck</a>/<a href="Throat" title="Throat">throat</a>/<a href="Jaw" title="Jaw">jaw</a> <a href="Pain" title="Pain">pain</a>/tightness/pressure, <a href="Dizziness" title="Dizziness">dizziness</a>, <a href="Paresthesia" title="Paresthesia">paresthesia</a>, <a href="Asthenia" class="mw-redirect" title="Asthenia">asthenia</a>, <a href="Somnolence" title="Somnolence">somnolence</a>, warm/cold sensations, <a href="Nausea" title="Nausea">nausea</a>, heaviness sensation, and <a href="Dry_mouth" class="mw-redirect" title="Dry mouth">dry mouth</a>.<sup id="cite_ref-Zolmig-Label_4-8" class="reference"><a href="#cite_note-Zolmig-Label-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>
</p><p>As for cardiovascular <a href="Side_effect" title="Side effect">side effects</a>, zolmitriptan can increase systolic blood pressure in the elderly and increase diastolic blood pressure in both the elderly and young people. Additionally, there is the side effect of a <a href="Dose_dependence" class="mw-redirect" title="Dose dependence">dose-related</a> increase in <a href="Sedation" title="Sedation">sedation</a>. There is a risk for <a href="Headache_attributed_to_a_substance_or_its_withdrawal" title="Headache attributed to a substance or its withdrawal">medication withdrawal headache</a> or <a href="Medication_overuse_headache" title="Medication overuse headache">medication overuse headache</a>.<sup id="cite_ref-statspe_7-4" class="reference"><a href="#cite_note-statspe-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup>
</p><p>Zolmitriptan has a weak <a href="Affinity_(pharmacology)" class="mw-redirect" title="Affinity (pharmacology)">affinity</a> for <a href="Serotonin" title="Serotonin">serotonin</a> <a href="5-HT1A_receptor" title="5-HT1A receptor">5-HT<sub>1A</sub> receptors</a>; these <a href="Receptor_(biochemistry)" title="Receptor (biochemistry)">receptors</a> have been implicated in the development of <a href="Serotonin_syndrome" title="Serotonin syndrome">serotonin syndrome</a>.<sup id="cite_ref-statspe_7-5" class="reference"><a href="#cite_note-statspe-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Overdose">Overdose</h2></div>
<p>There is limited experience with <a href="Overdose" class="mw-redirect" title="Overdose">overdose</a> of zolmitriptan and there is no specific <a href="Antidote" title="Antidote">antidote</a> for zolmitriptan overdose.<sup id="cite_ref-Zolmig-Label_4-9" class="reference"><a href="#cite_note-Zolmig-Label-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> A dose of zolmitriptan of 50<span class="nowrap"> </span>mg, which is 10- to 40-fold the clinically used dose range of 1.25 to 5<span class="nowrap"> </span>mg, commonly resulted in <a href="Sedation" title="Sedation">sedation</a> in patients in a clinical study.<sup id="cite_ref-Zolmig-Label_4-10" class="reference"><a href="#cite_note-Zolmig-Label-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> Zolmitriptan has a relatively short <a href="Elimination_half-life" class="mw-redirect" title="Elimination half-life">elimination half-life</a> of 3<span class="nowrap"> </span>hours, and so <a href="Symptom" class="mw-redirect" title="Symptom">symptoms</a> of overdose may be expected to resolve within around 15<span class="nowrap"> </span>hours post-intake.<sup id="cite_ref-Zolmig-Label_4-11" class="reference"><a href="#cite_note-Zolmig-Label-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2></div>
<p>Following administration of the <a href="Binding_selectivity" title="Binding selectivity">non-selective</a> <a href="Cytochrome_P450" title="Cytochrome P450">cytochrome P450</a> <a href="Enzyme_inhibitor" title="Enzyme inhibitor">inhibitor</a> <a href="Cimetidine" title="Cimetidine">cimetidine</a>, the <a href="Elimination_half-life" class="mw-redirect" title="Elimination half-life">elimination half-life</a> and <a href="Area-under-the-curve_(pharmacokinetics)" class="mw-redirect" title="Area-under-the-curve (pharmacokinetics)">total exposure</a> of zolmitriptan and its <a href="Active_metabolite" title="Active metabolite">active metabolite</a> were approximately doubled.<sup id="cite_ref-statspe_7-6" class="reference"><a href="#cite_note-statspe-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> The major <a href="Metabolite" title="Metabolite">metabolite</a> of zolmitriptan, <i>N</i>-desmethylzolmitriptan (183C91), which is active and has several-fold greater <a href="Affinity_(pharmacology)" class="mw-redirect" title="Affinity (pharmacology)">affinity</a> for the <a href="Serotonin" title="Serotonin">serotonin</a> <a href="5-HT1B_receptor" title="5-HT1B receptor">5-HT<sub>1B</sub></a> and <a href="5-HT1D_receptor" title="5-HT1D receptor">5-HT<sub>1D</sub> receptors</a> than zolmitriptan, is <a href="Drug_metabolism" title="Drug metabolism">metabolized</a> into an inactive form by <a href="Monoamine_oxidase_A" title="Monoamine oxidase A">monoamine oxidase A</a> (MAO-A).<sup id="cite_ref-Yu2008_3-2" class="reference"><a href="#cite_note-Yu2008-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> The <a href="Reversible_inhibitor_of_MAO-A" class="mw-redirect" title="Reversible inhibitor of MAO-A">reversible inhibitor of MAO-A</a> (RIMA) <a href="Moclobemide" title="Moclobemide">moclobemide</a> combined with zolmitriptan has been found to increase <i>N</i>-desmethylzolmitriptan exposure and peak levels by 1.5- to 3-fold.<sup id="cite_ref-Yu2008_3-3" class="reference"><a href="#cite_note-Yu2008-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Pharmacology">Pharmacology</h2></div>
<div class="mw-heading mw-heading3"><h3 id="Pharmacodynamics">Pharmacodynamics</h3></div>
<table class="wikitable floatright" style="font-size:small;">
<caption><span class="nowrap">Zolmitriptan activities</span>
</caption>
<tbody><tr>
<th><a href="Biological_target" title="Biological target">Target</a></th>
<th><a href="Affinity_(pharmacology)" class="mw-redirect" title="Affinity (pharmacology)">Affinity</a> (K<sub>i</sub>, nM)
</th></tr>
<tr>
<td><a href="5-HT1A_receptor" title="5-HT1A receptor">5-HT<sub>1A</sub></a></td>
<td>16–316 (K<sub>i</sub>)<br>3,020–>10,000 (<a href="Half-maximal_effective_concentration" class="mw-redirect" title="Half-maximal effective concentration"><abbr title="half-maximal effective concentration">EC<sub>50</sub></abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip half-maximal effective concentration</span>)<br>55% (<a href="Maximal_efficacy" class="mw-redirect" title="Maximal efficacy"><abbr title="maximal efficacy">E<sub>max</sub></abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip maximal efficacy</span>)
</td></tr>
<tr>
<td><a href="5-HT1B_receptor" title="5-HT1B receptor">5-HT<sub>1B</sub></a></td>
<td>0.47–20 (K<sub>i</sub>)<br>3.8–60 (<abbr title="half-maximal effective concentration">EC<sub>50</sub></abbr>)<br>99–102% (<abbr title="maximal efficacy">E<sub>max</sub></abbr>)
</td></tr>
<tr>
<td><a href="5-HT1D_receptor" title="5-HT1D receptor">5-HT<sub>1D</sub></a></td>
<td>0.11–4 (K<sub>i</sub>)<br>0.29–1.6 (<abbr title="half-maximal effective concentration">EC<sub>50</sub></abbr>)<br>86–106% (<abbr title="maximal efficacy">E<sub>max</sub></abbr>)
</td></tr>
<tr>
<td><a href="5-HT1E_receptor" title="5-HT1E receptor">5-HT<sub>1E</sub></a></td>
<td>10–>10,000 (K<sub>i</sub>)<br>6.6–62 (<abbr title="half-maximal effective concentration">EC<sub>50</sub></abbr>)<br>101% (<abbr title="maximal efficacy">E<sub>max</sub></abbr>)
</td></tr>
<tr>
<td><a href="5-HT1F_receptor" title="5-HT1F receptor">5-HT<sub>1F</sub></a></td>
<td>28–617 (K<sub>i</sub>)<br>10–420 (<abbr title="half-maximal effective concentration">EC<sub>50</sub></abbr>)<br>97% (<abbr title="maximal efficacy">E<sub>max</sub></abbr>)
</td></tr>
<tr>
<td><a href="5-HT2A_receptor" title="5-HT2A receptor">5-HT<sub>2A</sub></a></td>
<td>>10,000 (K<sub>i</sub>)<br>>10,000 (<abbr title="half-maximal effective concentration">EC<sub>50</sub></abbr>)
</td></tr>
<tr>
<td><a href="5-HT2B_receptor" title="5-HT2B receptor">5-HT<sub>2B</sub></a></td>
<td>65–>10,000 (K<sub>i</sub>)<br>>10,000 (<abbr title="half-maximal effective concentration">EC<sub>50</sub></abbr>)
</td></tr>
<tr>
<td><a href="5-HT2C_receptor" title="5-HT2C receptor">5-HT<sub>2C</sub></a></td>
<td>79,400 (K<sub>i</sub>) (guinea pig)<br><abbr title="No data">ND</abbr> (<abbr title="half-maximal effective concentration">EC<sub>50</sub></abbr>)
</td></tr>
<tr>
<td><a href="5-HT3_receptor" title="5-HT3 receptor">5-HT<sub>3</sub></a></td>
<td>>3,160 (mouse)
</td></tr>
<tr>
<td><a href="5-HT4_receptor" title="5-HT4 receptor">5-HT<sub>4</sub></a></td>
<td>>3,160 (guinea pig)
</td></tr>
<tr>
<td><a href="5-HT5A_receptor" title="5-HT5A receptor">5-HT<sub>5A</sub></a></td>
<td>398 (rat)
</td></tr>
<tr>
<td><a href="5-HT6_receptor" title="5-HT6 receptor">5-HT<sub>6</sub></a></td>
<td>>3,160
</td></tr>
<tr>
<td><a href="5-HT7_receptor" title="5-HT7 receptor">5-HT<sub>7</sub></a></td>
<td>87–96 (K<sub>i</sub>)<br>525 (<abbr title="half-maximal effective concentration">EC<sub>50</sub></abbr>)
</td></tr>
<tr>
<td><a href="Alpha-1A_adrenergic_receptor" title="Alpha-1A adrenergic receptor">α<sub>1A</sub></a>–<a href="Alpha-1D_adrenergic_receptor" title="Alpha-1D adrenergic receptor">α<sub>1D</sub></a></td>
<td><abbr title="No data">ND</abbr>
</td></tr>
<tr>
<td><a href="Alpha-2_adrenergic_receptor" title="Alpha-2 adrenergic receptor">α<sub>2</sub></a></td>
<td>79,000
</td></tr>
<tr>
<td><a href="Alpha-2A_adrenergic_receptor" title="Alpha-2A adrenergic receptor">α<sub>2A</sub></a>–<a href="Alpha-2C_adrenergic_receptor" title="Alpha-2C adrenergic receptor">α<sub>2C</sub></a></td>
<td><abbr title="No data">ND</abbr>
</td></tr>
<tr>
<td><a href="Beta-1_adrenergic_receptor" title="Beta-1 adrenergic receptor">β<sub>1</sub></a>–<a href="Beta-3_adrenergic_receptor" title="Beta-3 adrenergic receptor">β<sub>3</sub></a></td>
<td><abbr title="No data">ND</abbr>
</td></tr>
<tr>
<td><a href="D1_receptor" class="mw-redirect" title="D1 receptor">D<sub>1</sub></a>, <a href="D2_receptor" class="mw-redirect" title="D2 receptor">D<sub>2</sub></a></td>
<td>>100,000
</td></tr>
<tr>
<td><a href="D3_receptor" class="mw-redirect" title="D3 receptor">D<sub>3</sub></a>–<a href="D5_receptor" class="mw-redirect" title="D5 receptor">D<sub>5</sub></a></td>
<td><abbr title="No data">ND</abbr>
</td></tr>
<tr>
<td><a href="H1_receptor" class="mw-redirect" title="H1 receptor">H<sub>1</sub></a>–<a href="H4_receptor" class="mw-redirect" title="H4 receptor">H<sub>4</sub></a></td>
<td><abbr title="No data">ND</abbr>
</td></tr>
<tr>
<td><a href="Muscarinic_acetylcholine_M1_receptor" class="mw-redirect" title="Muscarinic acetylcholine M1 receptor">M<sub>1</sub></a>–<a href="M5_receptor" class="mw-redirect" title="M5 receptor">M<sub>5</sub></a></td>
<td><abbr title="No data">ND</abbr>
</td></tr>
<tr>
<td><a href="I1_receptor" class="mw-redirect" title="I1 receptor">I<sub>1</sub></a>, <a href="I2_receptor" class="mw-redirect" title="I2 receptor">I<sub>2</sub></a></td>
<td><abbr title="No data">ND</abbr>
</td></tr>
<tr>
<td><a href="Sigma-1_receptor" title="Sigma-1 receptor">σ<sub>1</sub></a>, <a href="Sigma-2_receptor" title="Sigma-2 receptor">σ<sub>2</sub></a></td>
<td><abbr title="No data">ND</abbr>
</td></tr>
<tr>
<td><a href="Trace_amine-associated_receptor_1" class="mw-redirect" title="Trace amine-associated receptor 1"><abbr title="Trace amine-associated receptor 1">TAAR1</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Trace amine-associated receptor 1</span></td>
<td><abbr title="No data">ND</abbr>
</td></tr>
<tr>
<td><a href="Serotonin_transporter" title="Serotonin transporter"><abbr title="Serotonin transporter">SERT</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Serotonin transporter</span></td>
<td><abbr title="No data">ND</abbr>
</td></tr>
<tr>
<td><a href="Norepinephrine_transporter" title="Norepinephrine transporter"><abbr title="Norepinephrine transporter">NET</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Norepinephrine transporter</span></td>
<td><abbr title="No data">ND</abbr>
</td></tr>
<tr>
<td><a href="Dopamine_transporter" title="Dopamine transporter"><abbr title="Dopamine transporter">DAT</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Dopamine transporter</span></td>
<td><abbr title="No data">ND</abbr>
</td></tr>
<tr class="sortbottom">
<td colspan="2" style="width: 1px; background-color:#eaecf0; text-align: center;"><b>Notes:</b> The smaller the value, the more avidly the drug binds to the site. All proteins are human unless otherwise specified. <b>Refs:</b> <sup id="cite_ref-BindingDB_10-0" class="reference"><a href="#cite_note-BindingDB-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-DeVriesVillalónSaxena1999_11-0" class="reference"><a href="#cite_note-DeVriesVillalónSaxena1999-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Tfelt-HansenDeVriesSaxena2000_12-0" class="reference"><a href="#cite_note-Tfelt-HansenDeVriesSaxena2000-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-DeleuHanssens2000_13-0" class="reference"><a href="#cite_note-DeleuHanssens2000-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-SaxenaTfelt-Hansen2001_14-0" class="reference"><a href="#cite_note-SaxenaTfelt-Hansen2001-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Brink1999_15-0" class="reference"><a href="#cite_note-Brink1999-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Broek2002_16-0" class="reference"><a href="#cite_note-Broek2002-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-MartinRobertsonMacLennan1997_17-0" class="reference"><a href="#cite_note-MartinRobertsonMacLennan1997-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-PauwelsTardifPalmier1997_18-0" class="reference"><a href="#cite_note-PauwelsTardifPalmier1997-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><br><sup id="cite_ref-GlenMartinHill1995_19-0" class="reference"><a href="#cite_note-GlenMartinHill1995-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-PerezFourrierSigogneau1995_20-0" class="reference"><a href="#cite_note-PerezFourrierSigogneau1995-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-PerezPauwelsFourrier1998_21-0" class="reference"><a href="#cite_note-PerezPauwelsFourrier1998-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-NelsonPhebusJohnson2010_22-0" class="reference"><a href="#cite_note-NelsonPhebusJohnson2010-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Rubio-BeltránLabastida-RamírezHaanes2019_23-0" class="reference"><a href="#cite_note-Rubio-BeltránLabastida-RamírezHaanes2019-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-PerezHalazyPauwels1999_24-0" class="reference"><a href="#cite_note-PerezHalazyPauwels1999-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-ReuterNeeb2012_25-0" class="reference"><a href="#cite_note-ReuterNeeb2012-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-MitsikostasWard2024_26-0" class="reference"><a href="#cite_note-MitsikostasWard2024-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Comer2002_27-0" class="reference"><a href="#cite_note-Comer2002-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup>
</td></tr></tbody></table>
<p>Zolmitriptan is a <a href="Binding_selectivity" title="Binding selectivity">selective</a> <a href="Serotonin" title="Serotonin">serotonin</a> <a href="5-HT1B_receptor" title="5-HT1B receptor">5-HT<sub>1B</sub></a> and <a href="5-HT1D_receptor" title="5-HT1D receptor">5-HT<sub>1D</sub> receptor</a> <a href="Agonist" title="Agonist">agonist</a> with weak <a href="Affinity_(pharmacology)" class="mw-redirect" title="Affinity (pharmacology)">affinity</a> for the serotonin <a href="5-HT1A_receptor" title="5-HT1A receptor">5-HT<sub>1A</sub> receptor</a>.<sup id="cite_ref-Tfelt-HansenDeVriesSaxena2000_12-1" class="reference"><a href="#cite_note-Tfelt-HansenDeVriesSaxena2000-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> It also has affinity for other <a href="Serotonin_receptor" class="mw-redirect" title="Serotonin receptor">serotonin receptors</a>, including the serotonin <a href="5-HT1E_receptor" title="5-HT1E receptor">5-HT<sub>1E</sub></a>, <a href="5-HT1F_receptor" title="5-HT1F receptor">5-HT<sub>1F</sub></a>, <a href="5-HT2B_receptor" title="5-HT2B receptor">5-HT<sub>2B</sub></a>, <a href="5-HT5A_receptor" title="5-HT5A receptor">5-HT<sub>5A</sub></a>, and <a href="5-HT7_receptor" title="5-HT7 receptor">5-HT<sub>7</sub> receptors</a>.<sup id="cite_ref-Tfelt-HansenDeVriesSaxena2000_12-2" class="reference"><a href="#cite_note-Tfelt-HansenDeVriesSaxena2000-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> Conversely, its affinities for the serotonin <a href="5-HT2A_receptor" title="5-HT2A receptor">5-HT<sub>2A</sub></a>, <a href="5-HT2C_receptor" title="5-HT2C receptor">5-HT<sub>2C</sub></a>, <a href="5-HT3_receptor" title="5-HT3 receptor">5-HT<sub>3</sub></a>, <a href="5-HT4_receptor" title="5-HT4 receptor">5-HT<sub>4</sub></a>, and <a href="5-HT6_receptor" title="5-HT6 receptor">5-HT<sub>6</sub> receptors</a> are negligible or undetectable.<sup id="cite_ref-Tfelt-HansenDeVriesSaxena2000_12-3" class="reference"><a href="#cite_note-Tfelt-HansenDeVriesSaxena2000-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Rubio-BeltránLabastida-RamírezHaanes2019_23-1" class="reference"><a href="#cite_note-Rubio-BeltránLabastida-RamírezHaanes2019-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> It is likewise inactive as a serotonin 5-HT<sub>2A</sub> receptor agonist.<sup id="cite_ref-Rubio-BeltránLabastida-RamírezHaanes2019_23-2" class="reference"><a href="#cite_note-Rubio-BeltránLabastida-RamírezHaanes2019-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup>
</p><p>Zolmitriptan's major <a href="Metabolite" title="Metabolite">metabolite</a>, <i>N</i>-desmethylzolmitriptan (183C91), is also active and has about 2- to 6-fold the affinity of zolmitriptan for the serotonin 5-HT<sub>1B</sub> and 5-HT<sub>1D</sub> receptors.<sup id="cite_ref-Yu2008_3-4" class="reference"><a href="#cite_note-Yu2008-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup>
</p><p>Its action on serotonin 5-HT<sub>1B</sub> and 5-HT<sub>1D</sub> receptors causes <a href="Vasoconstriction" title="Vasoconstriction">vasoconstriction</a> in <a href="Intracranial" class="mw-redirect" title="Intracranial">intracranial</a> <a href="Blood_vessel" title="Blood vessel">blood vessels</a>; as well it can inhibit the release of <a href="Pro-inflammatory" class="mw-redirect" title="Pro-inflammatory">pro-inflammatory</a> <a href="Neuropeptide" title="Neuropeptide">neuropeptides</a> from <a href="Trigeminal" class="mw-redirect" title="Trigeminal">trigeminal</a> <a href="Perivascular" class="mw-redirect" title="Perivascular">perivascular</a> <a href="Nerve_ending" class="mw-redirect" title="Nerve ending">nerve endings</a>. It crosses the <a href="Blood%E2%80%93brain_barrier" title="Blood–brain barrier">blood–brain barrier</a> as evidenced by the presence of <a href="Radiolabel" class="mw-redirect" title="Radiolabel">radiolabeled</a> zolmitriptan within the cells of the trigeminal nucleus caudalis and nucleus tractus solitarii.<sup id="cite_ref-statspe_7-7" class="reference"><a href="#cite_note-statspe-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading3"><h3 id="Pharmacokinetics">Pharmacokinetics</h3></div>
<div class="mw-heading mw-heading4"><h4 id="Absorption">Absorption</h4></div>
<p>Zolmitriptan has a rapid <a href="Onset_of_action" title="Onset of action">onset of action</a> and has been detected in the brain as early as within 5<span class="nowrap"> </span>minutes of <a href="Intranasal_administration" class="mw-redirect" title="Intranasal administration">intranasal administration</a>. On average, zolmitriptan has an <a href="Oral_administration" title="Oral administration">oral</a> <a href="Bioavailability" title="Bioavailability">bioavailability</a> of 40%, a mean <a href="Volume_of_distribution" title="Volume of distribution">volume of distribution</a> of 8.3<span class="nowrap"> </span>L/kg after oral administration, and 2.4<span class="nowrap"> </span>L/kg after intravenous administration.<sup id="cite_ref-statspe_7-8" class="reference"><a href="#cite_note-statspe-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> According to a study of healthy volunteers, food intake seems to have no significant effect on the effectiveness of zolmitriptan in both men and women.<sup id="cite_ref-28" class="reference"><a href="#cite_note-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading4"><h4 id="Distribution">Distribution</h4></div>
<p>Zolmitriptan is a more <a href="Lipophilic" class="mw-redirect" title="Lipophilic">lipophilic</a> <a href="Chemical_compound" title="Chemical compound">compound</a> with greater <a href="Central_nervous_system" title="Central nervous system">central</a> <a href="Drug_permeability" title="Drug permeability">permeability</a> than certain other <a href="Triptan" title="Triptan">triptans</a> like <a href="Sumatriptan" title="Sumatriptan">sumatriptan</a>.<sup id="cite_ref-Martin1997_29-0" class="reference"><a href="#cite_note-Martin1997-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-LionettoCasollaMastropietri2012_30-0" class="reference"><a href="#cite_note-LionettoCasollaMastropietri2012-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> It has been found to cross the <a href="Blood%E2%80%93brain_barrier" title="Blood–brain barrier">blood–brain barrier</a> and enter the <a href="Central_nervous_system" title="Central nervous system">central nervous system</a> both in animals and humans.<sup id="cite_ref-DeenChristensenHougaard2017_31-0" class="reference"><a href="#cite_note-DeenChristensenHougaard2017-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup> In a clinical <a href="Pharmacokinetic" class="mw-redirect" title="Pharmacokinetic">pharmacokinetic</a> study, brain concentrations were about 20% of plasma concentrations.<sup id="cite_ref-WallKågedalBergström2005_32-0" class="reference"><a href="#cite_note-WallKågedalBergström2005-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup> However, in another clinical study, the drug achieved relatively low <a href="Receptor_occupancy" class="mw-redirect" title="Receptor occupancy">occupancy</a> of central <a href="Serotonin" title="Serotonin">serotonin</a> <a href="5-HT1B_receptor" title="5-HT1B receptor">5-HT<sub>1B</sub> receptors</a> (4–5%) as measured by <a href="Positron_emission_tomography" title="Positron emission tomography">positron emission tomography</a> (PET) <a href="Medical_imaging" title="Medical imaging">imaging</a>.<sup id="cite_ref-DeenChristensenHougaard2017_31-1" class="reference"><a href="#cite_note-DeenChristensenHougaard2017-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-VarnäsJučaiteMcCarthy2013_33-0" class="reference"><a href="#cite_note-VarnäsJučaiteMcCarthy2013-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-WallKågedalBergström2005_32-1" class="reference"><a href="#cite_note-WallKågedalBergström2005-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading4"><h4 id="Metabolism">Metabolism</h4></div>
<p>Zolmitriptan is <a href="Drug_metabolism" title="Drug metabolism">metabolized</a> into three major <a href="Metabolite" title="Metabolite">metabolites</a> by the human <a href="Liver" title="Liver">hepatic</a> <a href="Cytochrome_P450" title="Cytochrome P450">cytochrome P450</a> <a href="Enzyme" title="Enzyme">enzymes</a>—primarily <a href="CYP1A2" title="CYP1A2">CYP1A2</a>. Two-thirds of the parent compound breaks down into the <a href="Active_metabolite" title="Active metabolite">active metabolite</a> <i>N</i>-desmethylzolmitriptan (183C91), while the remaining one-third separates into the other two inactive <a href="Metabolite" title="Metabolite">metabolites</a>: zolmitriptan <i>N</i>-oxide and an <a href="Indole-3-acetic_acid" title="Indole-3-acetic acid">indole acetic acid</a> <a href="Chemical_derivative" class="mw-redirect" title="Chemical derivative">derivative</a>.<sup id="cite_ref-Yu2008_3-5" class="reference"><a href="#cite_note-Yu2008-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> <i>N</i>-Desmethylzolmitriptan circulates at higher levels than those of zolmitriptan.<sup id="cite_ref-Yu2008_3-6" class="reference"><a href="#cite_note-Yu2008-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> This metabolite is <a href="Deamination" title="Deamination">deaminated</a> by <a href="Monoamine_oxidase_A" title="Monoamine oxidase A">monoamine oxidase A</a> (MAO-A).<sup id="cite_ref-Yu2008_3-7" class="reference"><a href="#cite_note-Yu2008-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading4"><h4 id="Elimination">Elimination</h4></div>
<p>Zolmitriptan has an <a href="Elimination_half-life" class="mw-redirect" title="Elimination half-life">elimination half-life</a> of about 3<span class="nowrap"> </span>hours before it undergoes <a href="Kidney" title="Kidney">renal</a> <a href="Elimination_(pharmacology)" title="Elimination (pharmacology)">elimination</a>; its <a href="Clearance_(pharmacology)" title="Clearance (pharmacology)">clearance</a> is greater than the <a href="Glomerular_filtration_rate" title="Glomerular filtration rate">glomerular filtration rate</a> suggesting that there is some renal tubular secretion of the compound.<sup id="cite_ref-statspe_7-9" class="reference"><a href="#cite_note-statspe-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Chemistry">Chemistry</h2></div>
<p>Zolmitriptan, also known as [(4<i>S</i>)-2-oxo-1,3-oxazolidin-4-yl]methyl-<i>N</i>,<i>N</i>-dimethyltryptamine, is a <a href="Substituted_tryptamine" title="Substituted tryptamine">tryptamine</a> <a href="Chemical_derivative" class="mw-redirect" title="Chemical derivative">derivative</a> and a 5-substituted derivative of the <a href="Psychedelic_drug" title="Psychedelic drug">psychedelic drug</a> <a href="Dimethyltryptamine" title="Dimethyltryptamine">dimethyltryptamine</a> (DMT).<sup id="cite_ref-Zolmig-Label_4-12" class="reference"><a href="#cite_note-Zolmig-Label-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-PubChem_5-1" class="reference"><a href="#cite_note-PubChem-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> It is specifically the <a href="Chemical_derivative" class="mw-redirect" title="Chemical derivative">derivative</a> of DMT in which the <a href="Hydrogen" title="Hydrogen">hydrogen</a> <a href="Atom" title="Atom">atom</a> at position 5 of the <a href="Indole" title="Indole">indole</a> <a href="Ring_(chemistry)" title="Ring (chemistry)">ring</a> has been <a href="Chemical_substituent" class="mw-redirect" title="Chemical substituent">substituted</a> with a [(4<i>S</i>)-2-oxo-1,3-oxazolidin-4-yl]methyl <a href="Functional_group" title="Functional group">group</a>.<sup id="cite_ref-PubChem_5-2" class="reference"><a href="#cite_note-PubChem-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup>
</p><p>The experimental <a href="Partition_coefficient" title="Partition coefficient">log P</a> of zolmitriptan is 1.6 to 1.8.<sup id="cite_ref-PubChem_5-3" class="reference"><a href="#cite_note-PubChem-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-TekesSzegiHashemi2013_34-0" class="reference"><a href="#cite_note-TekesSzegiHashemi2013-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup> For comparison, the experimental log P of <a href="Sumatriptan" title="Sumatriptan">sumatriptan</a> is 0.8 to 0.93.<sup id="cite_ref-PubChem-Sumatriptan_35-0" class="reference"><a href="#cite_note-PubChem-Sumatriptan-35"><span class="cite-bracket">[</span>35<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-TekesSzegiHashemi2013_34-1" class="reference"><a href="#cite_note-TekesSzegiHashemi2013-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup> Zolmitriptan is much more <a href="Lipophilic" class="mw-redirect" title="Lipophilic">lipophilic</a> than sumatriptan.<sup id="cite_ref-Tfelt-HansenDeVriesSaxena2000_12-4" class="reference"><a href="#cite_note-Tfelt-HansenDeVriesSaxena2000-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-TekesSzegiHashemi2013_34-2" class="reference"><a href="#cite_note-TekesSzegiHashemi2013-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup>
</p><p><a href="Structural_analog" title="Structural analog">Analogues</a> of zolmitriptan include other triptans like sumatriptan, <a href="Naratriptan" title="Naratriptan">naratriptan</a>, <a href="Rizatriptan" title="Rizatriptan">rizatriptan</a>, <a href="Eletriptan" title="Eletriptan">eletriptan</a>, <a href="Almotriptan" title="Almotriptan">almotriptan</a>, and <a href="Frovatriptan" title="Frovatriptan">frovatriptan</a>.<sup id="cite_ref-Tfelt-HansenDeVriesSaxena2000_12-5" class="reference"><a href="#cite_note-Tfelt-HansenDeVriesSaxena2000-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-TekesSzegiHashemi2013_34-3" class="reference"><a href="#cite_note-TekesSzegiHashemi2013-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="History">History</h2></div>
<p>Zolmitriptan was <a href="Patent" title="Patent">patented</a> in 1990<sup id="cite_ref-Fis2006_6-1" class="reference"><a href="#cite_note-Fis2006-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> and was first described in the <a href="Scientific_literature" title="Scientific literature">scientific literature</a> by 1994.<sup id="cite_ref-GoadsbyEdvinsson1994_36-0" class="reference"><a href="#cite_note-GoadsbyEdvinsson1994-36"><span class="cite-bracket">[</span>36<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Martin1994_37-0" class="reference"><a href="#cite_note-Martin1994-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-PeckDixonSeaber1994_38-0" class="reference"><a href="#cite_note-PeckDixonSeaber1994-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup> It was first introduced for medical use in the <a href="United_States" title="United States">United States</a> in 1997.<sup id="cite_ref-Fis2006_6-2" class="reference"><a href="#cite_note-Fis2006-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Zolmig-Label_4-13" class="reference"><a href="#cite_note-Zolmig-Label-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-AdisInsight_39-0" class="reference"><a href="#cite_note-AdisInsight-39"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Society_and_culture">Society and culture</h2></div>
<div class="mw-heading mw-heading3"><h3 id="Brand_names">Brand names</h3></div>
<p>Zolmitriptan is marketed by <a href="AstraZeneca" title="AstraZeneca">AstraZeneca</a> with the brand names Zomig, Zomigon (Argentina, Canada, and Greece), AscoTop (Germany) and Zomigoro (France).
</p>
<div class="mw-heading mw-heading3"><h3 id="Economics">Economics</h3></div>
<p>In 2008, Zomig generated nearly $154 million in sales.<sup id="cite_ref-40" class="reference"><a href="#cite_note-40"><span class="cite-bracket">[</span>40<span class="cite-bracket">]</span></a></sup>
</p><p>AstraZeneca's U.S. patent on Zomig tablets expired on November 14, 2012, and its pediatric exclusivity extension expired on May 14, 2013.<sup id="cite_ref-41" class="reference"><a href="#cite_note-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup> The patent in certain European countries has already expired too, and generic drug maker <a href="Actavis" title="Actavis">Actavis</a> released a generic version in those countries, starting in March 2012.<sup id="cite_ref-42" class="reference"><a href="#cite_note-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading3"><h3 id="Legal_status">Legal status</h3></div>
<p>In <a href="Russia" title="Russia">Russia</a>, versions of zolmitriptan which are not registered in the National registry of medications may be regarded as narcotic drugs (derivatives of <a href="N%2CN-Dimethyltryptamine" class="mw-redirect" title="N,N-Dimethyltryptamine">dimethyltriptamine</a>).<sup id="cite_ref-Order681_43-0" class="reference"><a href="#cite_note-Order681-43"><span class="cite-bracket">[</span>43<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Research">Research</h2></div>
<div class="mw-heading mw-heading3"><h3 id="Obsessive–compulsive_disorder">Obsessive–compulsive disorder</h3></div>
<p>Zolmitriptan showed no effect on <a href="Obsessive%E2%80%93compulsive_disorder" title="Obsessive–compulsive disorder">obsessive–compulsive disorder</a> (OCD) symptoms nor on <a href="Mood_(psychology)" title="Mood (psychology)">mood</a> or <a href="Anxiety" title="Anxiety">anxiety</a> in a <a href="Clinical_study" class="mw-redirect" title="Clinical study">clinical study</a>.<sup id="cite_ref-TigerVarnäsOkubo2018_44-0" class="reference"><a href="#cite_note-TigerVarnäsOkubo2018-44"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-BoshuisendenBoer2000_45-0" class="reference"><a href="#cite_note-BoshuisendenBoer2000-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading3"><h3 id="Social_deficits_and_aggression">Social deficits and aggression</h3></div>
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</style><div role="note" class="hatnote navigation-not-searchable">See also: <a href="Serenic#Examples" title="Serenic">Serenic § Examples</a>, <a href="Entactogen#Mechanism_of_action" title="Entactogen">Entactogen § Mechanism of action</a>, and <a href="List_of_investigational_aggression_drugs" title="List of investigational aggression drugs">List of investigational aggression drugs</a></div>
<p>Zolmitriptan, in a <a href="Modified-release_dosage" title="Modified-release dosage">modified-release</a> <a href="Drug_formulation" class="mw-redirect" title="Drug formulation">formulation</a> with code name <i>ML-004</i> (or <i>ML004</i>), is under development by MapLight Therapeutics for the treatment of <a href="Pervasive_developmental_disorder" title="Pervasive developmental disorder">pervasive developmental disorders</a> (e.g., <a href="Autism" title="Autism">autism</a>), <a href="Psychomotor_agitation" title="Psychomotor agitation">agitation</a>, and <a href="Aggression" title="Aggression">aggression</a>.<sup id="cite_ref-AdisInsight-ML-004_46-0" class="reference"><a href="#cite_note-AdisInsight-ML-004-46"><span class="cite-bracket">[</span>46<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Synapse2024_47-0" class="reference"><a href="#cite_note-Synapse2024-47"><span class="cite-bracket">[</span>47<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-TheTransmitter2023_48-0" class="reference"><a href="#cite_note-TheTransmitter2023-48"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-WangClarkHanratty2024_49-0" class="reference"><a href="#cite_note-WangClarkHanratty2024-49"><span class="cite-bracket">[</span>49<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Cortica_50-0" class="reference"><a href="#cite_note-Cortica-50"><span class="cite-bracket">[</span>50<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-PharmTech2024_51-0" class="reference"><a href="#cite_note-PharmTech2024-51"><span class="cite-bracket">[</span>51<span class="cite-bracket">]</span></a></sup> The drug has been found to reduce aggression in rodents<sup id="cite_ref-Rasia-FilhoGiovenardide_Almeida2008_52-0" class="reference"><a href="#cite_note-Rasia-FilhoGiovenardide_Almeida2008-52"><span class="cite-bracket">[</span>52<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-deBoerKoolhaas2005_53-0" class="reference"><a href="#cite_note-deBoerKoolhaas2005-53"><span class="cite-bracket">[</span>53<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-deAlmeidaNikulinaFaccidomo2001_54-0" class="reference"><a href="#cite_note-deAlmeidaNikulinaFaccidomo2001-54"><span class="cite-bracket">[</span>54<span class="cite-bracket">]</span></a></sup> and has also been reported to decrease aggression in humans.<sup id="cite_ref-TricklebankRobbinsSimmons2021_55-0" class="reference"><a href="#cite_note-TricklebankRobbinsSimmons2021-55"><span class="cite-bracket">[</span>55<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-GowinSwannMoeller2010_56-0" class="reference"><a href="#cite_note-GowinSwannMoeller2010-56"><span class="cite-bracket">[</span>56<span class="cite-bracket">]</span></a></sup> As of June 2023, zolmitriptan is in <a href="Phases_of_clinical_research#Phase_II" title="Phases of clinical research">phase 2</a> <a href="Clinical_trial" title="Clinical trial">clinical trials</a> for pervasive developmental disorders, <a href="Phases_of_clinical_research#Phase_I" title="Phases of clinical research">phase 1</a> clinical trials for agitation, and is in the <a href="Preclinical_research" class="mw-redirect" title="Preclinical research">preclinical stage of development</a> for aggression.<sup id="cite_ref-AdisInsight-ML-004_46-1" class="reference"><a href="#cite_note-AdisInsight-ML-004-46"><span class="cite-bracket">[</span>46<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Synapse2024_47-1" class="reference"><a href="#cite_note-Synapse2024-47"><span class="cite-bracket">[</span>47<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-TheTransmitter2023_48-1" class="reference"><a href="#cite_note-TheTransmitter2023-48"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="References">References</h2></div>
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<li id="cite_note-Broek2002-16"><span class="mw-cite-backlink"><b><a href="#cite_ref-Broek2002_16-0">^</a></b></span> <span class="reference-text"><cite id="CITEREFvan_den_Broek2002" class="citation web cs1">van den Broek RW (13 March 2002). <a rel="nofollow" class="external text" href="https://repub.eur.nl/pub/16167/">"Vascular Effects of Antimigraine Drugs: pharmacology of human in vitro models in migraine"</a>. <i>RePub, Erasmus University Repository</i><span class="reference-accessdate">. Retrieved <span class="nowrap">19 June</span> 2025</span>. <q>Table 1.2 Receptor binding properties (pKi values) of the triptans at human 5-HT receptors. [...]</q></cite></span>
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<li id="cite_note-DeenChristensenHougaard2017-31"><span class="mw-cite-backlink">^ <a href="#cite_ref-DeenChristensenHougaard2017_31-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-DeenChristensenHougaard2017_31-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><cite id="CITEREFDeenChristensenHougaardHansen2017" class="citation journal cs1">Deen M, Christensen CE, Hougaard A, Hansen HD, Knudsen GM, Ashina M (March 2017). "Serotonergic mechanisms in the migraine brain - a systematic review". <i>Cephalalgia</i>. <b>37</b> (3): <span class="nowrap">251–</span>264. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1177%2F0333102416640501">10.1177/0333102416640501</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27013238">27013238</a>. <q>The central mechanisms of triptans are a subject of intense debate and have been investigated in several studies. Brain PET studies reported that zolmitriptan crosses the BBB and binds to central 5-HT1B receptors with relatively low occupancy (77,78). It is still unknown whether sumatriptan has a central effect.</q></cite></span>
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<li id="cite_note-BoshuisendenBoer2000-45"><span class="mw-cite-backlink"><b><a href="#cite_ref-BoshuisendenBoer2000_45-0">^</a></b></span> <span class="reference-text"><cite id="CITEREFBoshuisenden_Boer2000" class="citation journal cs1">Boshuisen ML, den Boer JA (September 2000). "Zolmitriptan (a 5-HT1B/1D receptor agonist with central action) does not increase symptoms in obsessive compulsive disorder". <i>Psychopharmacology (Berl)</i>. <b>152</b> (1): <span class="nowrap">74–</span>79. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs002130000529">10.1007/s002130000529</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11041318">11041318</a>.</cite></span>
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<li id="cite_note-TheTransmitter2023-48"><span class="mw-cite-backlink">^ <a href="#cite_ref-TheTransmitter2023_48-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-TheTransmitter2023_48-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><cite id="CITEREFHess2023" class="citation web cs1">Hess P (28 April 2023). <a rel="nofollow" class="external text" href="https://www.thetransmitter.org/spectrum/going-on-trial-serotonin-drug-psilocybin-phase-2-placebo-response-data/">"Going on Trial: Serotonin drug; psilocybin phase 2; placebo response data"</a>. <i>The Transmitter: Neuroscience News and Perspectives</i><span class="reference-accessdate">. Retrieved <span class="nowrap">27 October</span> 2024</span>.</cite></span>
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<li id="cite_note-WangClarkHanratty2024-49"><span class="mw-cite-backlink"><b><a href="#cite_ref-WangClarkHanratty2024_49-0">^</a></b></span> <span class="reference-text"><cite id="CITEREFWangClarkHanrattyKoblan2024" class="citation journal cs1">Wang L, Clark EA, Hanratty L, Koblan KS, Foley A, Dedic N, et al. (August 2024). "TAAR1 and 5-HT1B receptor agonists attenuate autism-like irritability and aggression in rats prenatally exposed to valproic acid". <i>Pharmacol Biochem Behav</i>. <b>245</b> 173862. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.pbb.2024.173862">10.1016/j.pbb.2024.173862</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/39197535">39197535</a>. <q>Interest in 5-HT1B as a target for ASD is further evidenced by the ongoing Phase 2 clinical trial of ML-004, a modified release form of the 5-HT1B/1D agonist zolmitriptan, which is being evaluated for the treatment of social communication deficits in adolescent and adult subjects with ASD (NCT05081245).</q></cite></span>
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<li id="cite_note-Cortica-50"><span class="mw-cite-backlink"><b><a href="#cite_ref-Cortica_50-0">^</a></b></span> <span class="reference-text"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.corticacare.com/research/maplight">"Maplight Autism Study"</a>. <i>Cortica</i><span class="reference-accessdate">. Retrieved <span class="nowrap">27 October</span> 2024</span>. <q>Purpose: The purpose of this study is to find out whether ML-004, an extended-release version of zolmitriptan, can support with sociability and emotional regulation in adults with ASD.</q></cite></span>
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<li id="cite_note-PharmTech2024-51"><span class="mw-cite-backlink"><b><a href="#cite_ref-PharmTech2024_51-0">^</a></b></span> <span class="reference-text"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20240522133617/https://www.pharmaceutical-technology.com/data-insights/zolmitriptan-maplight-therapeutics-autism-spectrum-disorder-asd-likelihood-of-approval/">"Zolmitriptan by MapLight therapeutics for Autism Spectrum Disorder (ASD): Likelihood of Approval"</a>. Archived from <a rel="nofollow" class="external text" href="https://www.pharmaceutical-technology.com/data-insights/zolmitriptan-maplight-therapeutics-autism-spectrum-disorder-asd-likelihood-of-approval/">the original</a> on 22 May 2024.</cite></span>
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<li id="cite_note-Rasia-FilhoGiovenardide_Almeida2008-52"><span class="mw-cite-backlink"><b><a href="#cite_ref-Rasia-FilhoGiovenardide_Almeida2008_52-0">^</a></b></span> <span class="reference-text"><cite id="CITEREFRasia-FilhoGiovenardide_Almeida2008" class="citation journal cs1">Rasia-Filho AA, Giovenardi M, de Almeida RM (January 2008). "Drugs and aggression". <i>Recent Pat CNS Drug Discov</i>. <b>3</b> (1): <span class="nowrap">40–</span>49. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2174%2F157488908783421456">10.2174/157488908783421456</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18221240">18221240</a>. <q>In addition, the 5-HT1B receptors are of potential importance as target for treatment of different disorders such as depression, schizophrenia, Parkinson's disease, and impulsive disorders [133]. Drugs acting as agonists at 5- HT1B receptors, when administered systemically, potently and efficaciously inhibit several types of aggressive behavior in mice [17,135; and for review see 63]. Systemically administered 5-HT1B receptor agonists such as CP-94,253, ampirtoline and zolmitriptan exert anti-aggressive effects in mice with moderate or high levels of aggression, without impairing non-aggressive activities [17, 23, 129,135]. Further support for the significant role of this receptor subtype derives from the finding of increased aggression in mutant 129Sv mice lacking the 5-HT1B receptor gene [136, and see 137].</q></cite></span>
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<li id="cite_note-deBoerKoolhaas2005-53"><span class="mw-cite-backlink"><b><a href="#cite_ref-deBoerKoolhaas2005_53-0">^</a></b></span> <span class="reference-text"><cite id="CITEREFde_BoerKoolhaas2005" class="citation journal cs1">de Boer SF, Koolhaas JM (December 2005). "5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis". <i>Eur J Pharmacol</i>. <b>526</b> (<span class="nowrap">1–</span>3): <span class="nowrap">125–</span>139. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.ejphar.2005.09.065">10.1016/j.ejphar.2005.09.065</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16310183">16310183</a>. <q>Using such an ethopharmacological approach in either rats or mice, it has recently been claimed that only certain specific 5-HT1A receptor agonists (i.e., alnespirone and S-15535; de Boer et al., 1999, 2000), a mixed 5-HT1A/1B receptor agonist (i.e., eltoprazine; Olivier et al., 1995) and several specific 5-HT1B receptor agonists (i.e., CGS12066b, CP-94,253, anpirtoline, zolmitriptan, sumatriptan; Bell and Hobson, 1994; Fish et al., 1999; De Almeida et al., 2001; Miczek et al., 2004) exert behavioral specific anti-aggressive effects. In particular, it was claimed that agonists acting on the 5-HT1B receptors have more selective anti-aggressive effects in mice than those acting on 5-HT1A receptors (Miczek et al., 2004; Olivier, 2004).</q></cite></span>
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<li id="cite_note-deAlmeidaNikulinaFaccidomo2001-54"><span class="mw-cite-backlink"><b><a href="#cite_ref-deAlmeidaNikulinaFaccidomo2001_54-0">^</a></b></span> <span class="reference-text"><cite id="CITEREFde_AlmeidaNikulinaFaccidomoFish2001" class="citation journal cs1">de Almeida RM, Nikulina EM, Faccidomo S, Fish EW, Miczek KA (September 2001). "Zolmitriptan--a 5-HT1B/D agonist, alcohol, and aggression in mice". <i>Psychopharmacology (Berl)</i>. <b>157</b> (2): <span class="nowrap">131–</span>141. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs002130100778">10.1007/s002130100778</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11594437">11594437</a>.</cite></span>
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<li id="cite_note-TricklebankRobbinsSimmons2021-55"><span class="mw-cite-backlink"><b><a href="#cite_ref-TricklebankRobbinsSimmons2021_55-0">^</a></b></span> <span class="reference-text"><cite id="CITEREFTricklebankRobbinsSimmonsWong2021" class="citation journal cs1">Tricklebank MD, Robbins TW, Simmons C, Wong EH (June 2021). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7945970">"Time to re-engage psychiatric drug discovery by strengthening confidence in preclinical psychopharmacology"</a>. <i>Psychopharmacology (Berl)</i>. <b>238</b> (6): <span class="nowrap">1417–</span>1436. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs00213-021-05787-x">10.1007/s00213-021-05787-x</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7945970">7945970</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/33694032">33694032</a>. <q>A high proportion of violent acts are committed under the influence of alcohol. Aggressive behaviour can also be primed in the mouse by exposure to alcohol (De Almeida et al. 2001). In findings that are consistent with our knowledge of the relationship between serotonin and aggression (Pihl and Lemarquand 1998), this impact of alcohol can be ameliorated by treatment with the 5-HT1B/1D receptor agonist zolmitriptan, an approved anti-migraine drug. However, these findings have seemingly been overlooked despite the consistency of rodent and human data (Gowin et al. 2010).</q></cite></span>
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<li id="cite_note-GowinSwannMoeller2010-56"><span class="mw-cite-backlink"><b><a href="#cite_ref-GowinSwannMoeller2010_56-0">^</a></b></span> <span class="reference-text"><cite id="CITEREFGowinSwannMoellerLane2010" class="citation journal cs1">Gowin JL, Swann AC, Moeller FG, Lane SD (July 2010). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150756">"Zolmitriptan and human aggression: interaction with alcohol"</a>. <i>Psychopharmacology (Berl)</i>. <b>210</b> (4): <span class="nowrap">521–</span>531. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs00213-010-1851-6">10.1007/s00213-010-1851-6</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150756">9150756</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20407761">20407761</a>.</cite></span>
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</ol></div></div>
<div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2></div>
<ul><li><cite id="CITEREFMacGregor1998" class="citation journal cs1">MacGregor EA (1998). "Zolmitriptan clinical studies". <i>Drugs Today</i>. <b>34</b> (12): <span class="nowrap">1027–</span>1033. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1358%2Fdot.1998.34.12.487488">10.1358/dot.1998.34.12.487488</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14743270">14743270</a>.</cite></li></ul>
<div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2></div>
<ul><li><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://medlineplus.gov/druginfo/meds/a605046.html">"Zolmitriptan Nasal Spray"</a>. <i>MedlinePlus</i>.</cite></li></ul>
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</style><div id="Antimigraine_preparations_(N02C)205" style="font-size:114%;margin:0 4em"><a href="Antimigraine_drug" title="Antimigraine drug">Antimigraine preparations</a> (<a href="ATC_code_N02#N02C" title="ATC code N02">N02C</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Management_of_chronic_headaches#Analgesic_and_abortive_medications" title="Management of chronic headaches">Analgesic/abortive</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Serotonin" title="Serotonin">Serotonergics</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Ergoline" title="Ergoline">Ergolines</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Dihydroergocryptine" title="Dihydroergocryptine">Dihydroergocryptine</a></li>
<li><a href="Dihydroergotamine" title="Dihydroergotamine">Dihydroergotamine</a></li>
<li><a href="Ergotamine" title="Ergotamine">Ergotamine</a> (<a href="Ergotamine/caffeine" title="Ergotamine/caffeine">+caffeine</a>, <a href="Ergotamine/chlorcyclizine/caffeine" title="Ergotamine/chlorcyclizine/caffeine">+chlorcyclizine/caffeine</a>)</li>
<li><a href="Lisuride" title="Lisuride">Lisuride</a></li>
<li><a href="Methylergometrine" title="Methylergometrine">Methylergometrine</a></li>
<li><a href="Methysergide" title="Methysergide">Methysergide</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Serotonin_receptor_agonist" title="Serotonin receptor agonist">5-HT<sub>1</sub> agonists</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Triptan" title="Triptan">Triptans</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Almotriptan" title="Almotriptan">Almotriptan</a></li>
<li><a href="Avitriptan" title="Avitriptan">Avitriptan</a><sup>†</sup></li>
<li><a href="Donitriptan" title="Donitriptan">Donitriptan</a><sup>§</sup></li>
<li><a href="Eletriptan" title="Eletriptan">Eletriptan</a></li>
<li><a href="Frovatriptan" title="Frovatriptan">Frovatriptan</a></li>
<li><a href="Naratriptan" title="Naratriptan">Naratriptan</a></li>
<li><a href="Rizatriptan" title="Rizatriptan">Rizatriptan</a> (<a href="Meloxicam/rizatriptan" title="Meloxicam/rizatriptan">+meloxicam</a>)</li>
<li><a href="Sumatriptan" title="Sumatriptan">Sumatriptan</a></li>
</ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Ditan" title="Ditan">Ditans</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Alniditan" title="Alniditan">Alniditan</a><sup>†</sup></li>
<li><a href="Lasmiditan" title="Lasmiditan">Lasmiditan</a></li></ul>
</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Others</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Dimetotiazine" title="Dimetotiazine">Dimetotiazine</a></li>
<li><a href="Dotarizine" title="Dotarizine">Dotarizine</a></li>
<li><a href="Iprazochrome" title="Iprazochrome">Iprazochrome</a></li>
<li><a href="Oxetorone" title="Oxetorone">Oxetorone</a></li>
<li><a href="Pizotifen" title="Pizotifen">Pizotifen</a></li></ul>
</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Calcitonin_gene-related_peptide_receptor_antagonist" title="Calcitonin gene-related peptide receptor antagonist">CGRP-R antagonists</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Rimegepant" title="Rimegepant">Rimegepant</a></li>
<li><a href="Ubrogepant" title="Ubrogepant">Ubrogepant</a></li>
<li><a href="Zavegepant" title="Zavegepant">Zavegepant</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Others</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Paracetamol" title="Paracetamol">Paracetamol</a><sup>#</sup></li>
<li><a href="Amidrine" title="Amidrine">Amidrine</a></li></ul>
</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Prevention_of_migraines" class="mw-redirect" title="Prevention of migraines">Prophylactic</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Calcium_channel_blocker" title="Calcium channel blocker">Calcium channel blockers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Dotarizine" title="Dotarizine">Dotarizine</a></li>
<li><a href="Lomerizine" title="Lomerizine">Lomerizine</a></li>
<li><a href="Verapamil" title="Verapamil">Verapamil</a></li>
<li><a href="Flunarizine" title="Flunarizine">Flunarizine</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Progestogen" title="Progestogen">Progestogens</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Flumedroxone_acetate" title="Flumedroxone acetate">Flumedroxone acetate</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Sympatholytic" title="Sympatholytic">Sympatholytics</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Beta_blocker" title="Beta blocker">Beta blockers</a>
<ul><li><a href="Propranolol" title="Propranolol">Propranolol</a><sup>#</sup></li>
<li><a href="Timolol" title="Timolol">Timolol</a></li></ul></li>
<li><a href="Clonidine" title="Clonidine">Clonidine</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Tricyclic_antidepressant" title="Tricyclic antidepressant">Tricyclic antidepressants</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Amitriptyline" title="Amitriptyline">Amitriptyline</a></li>
<li><a href="Nortriptyline" title="Nortriptyline">Nortriptyline</a></li>
<li><a href="Imipramine" title="Imipramine">Imipramine</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Anticonvulsant" title="Anticonvulsant">Anticonvulsants</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Carbamazepine" title="Carbamazepine">Carbamazepine</a></li>
<li><a href="Oxcarbazepine" title="Oxcarbazepine">Oxcarbazepine</a></li>
<li><a href="Topiramate" title="Topiramate">Topiramate</a></li>
<li><a href="Valproate" title="Valproate">Valproate</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Anti-<a href="Calcitonin_gene-related_peptide" title="Calcitonin gene-related peptide">CGRP</a>/<a href="CALCRL" title="CALCRL">CGRP-R</a> <a href="Monoclonal_antibody" title="Monoclonal antibody">mAbs</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Eptinezumab" title="Eptinezumab">Eptinezumab</a></li>
<li><a href="Erenumab" title="Erenumab">Erenumab</a></li>
<li><a href="Fremanezumab" title="Fremanezumab">Fremanezumab</a></li>
<li><a href="Galcanezumab" title="Galcanezumab">Galcanezumab</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Calcitonin_gene-related_peptide_receptor_antagonist" title="Calcitonin gene-related peptide receptor antagonist">CGRP-R antagonists</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Atogepant" title="Atogepant">Atogepant</a></li>
<li><a href="Rimegepant" title="Rimegepant">Rimegepant</a></li></ul>
</div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><div class="hlist">
<ul><li><sup>#</sup><a href="WHO_Model_List_of_Essential_Medicines" title="WHO Model List of Essential Medicines">WHO-EM</a></li>
<li><sup>‡</sup><a href="List_of_withdrawn_drugs" title="List of withdrawn drugs">Withdrawn</a> from market</li>
<li><a href="Clinical_trial" title="Clinical trial">Clinical trials</a>:
<ul><li><sup>†</sup><a href="Phases_of_clinical_research#Phase_III" title="Phases of clinical research">Phase III</a></li>
<li><sup>§</sup>Never to phase III</li></ul></li></ul>
</div></div></td></tr></tbody></table></div>
<div class="navbox-styles"></div><div role="navigation" class="navbox" aria-labelledby="Serotonin_receptor_modulators766" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Serotonin_receptor_modulators766" style="font-size:114%;margin:0 4em"><a href="5-HT_receptor" title="5-HT receptor">Serotonin receptor</a> <a href="Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="5-HT1_receptor" title="5-HT1 receptor">5-HT<sub>1</sub></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="5-HT1A_receptor" title="5-HT1A receptor">5-HT<sub>1A</sub></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Agonists:</i> <a href="8-OH-DPAT" title="8-OH-DPAT">8-OH-DPAT</a></li>
<li><a href="Adatanserin" title="Adatanserin">Adatanserin</a></li>
<li><a href="Amphetamine" title="Amphetamine">Amphetamine</a></li>
<li><a href="Antidepressant" title="Antidepressant">Antidepressants</a> (e.g., <a href="Etoperidone" title="Etoperidone">etoperidone</a>, <a href="Hydroxynefazodone" title="Hydroxynefazodone">hydroxynefazodone</a>, <a href="Nefazodone" title="Nefazodone">nefazodone</a>, <a href="Trazodone" title="Trazodone">trazodone</a>, <a href="Triazoledione" title="Triazoledione">triazoledione</a>, <a href="Vilazodone" title="Vilazodone">vilazodone</a>, <a href="Vortioxetine" title="Vortioxetine">vortioxetine</a>)</li>
<li><a href="Atypical_antipsychotic" title="Atypical antipsychotic">Atypical antipsychotics</a> (e.g., <a href="Aripiprazole" title="Aripiprazole">aripiprazole</a>, <a href="Asenapine" title="Asenapine">asenapine</a>, <a href="Brexpiprazole" title="Brexpiprazole">brexpiprazole</a>, <a href="Cariprazine" title="Cariprazine">cariprazine</a>, <a href="Clozapine" title="Clozapine">clozapine</a>, <a href="Lurasidone" title="Lurasidone">lurasidone</a>, <a href="Quetiapine" title="Quetiapine">quetiapine</a>, <a href="Ziprasidone" title="Ziprasidone">ziprasidone</a>)</li>
<li><a href="Azapirone" title="Azapirone">Azapirones</a> (e.g., <a href="Buspirone" title="Buspirone">buspirone</a>, <a href="Eptapirone" title="Eptapirone">eptapirone</a>, <a href="Gepirone" title="Gepirone">gepirone</a>, <a href="Perospirone" title="Perospirone">perospirone</a>, <a href="Tandospirone" title="Tandospirone">tandospirone</a>)</li>
<li><a href="Bay_R_1531" title="Bay R 1531">Bay R 1531</a></li>
<li><a href="Befiradol" title="Befiradol">Befiradol</a></li>
<li><a href="BMY-14802" title="BMY-14802">BMY-14802</a></li>
<li><a href="Cannabidiol" title="Cannabidiol">Cannabidiol</a></li>
<li><a href="Dimemebfe" title="Dimemebfe">Dimemebfe</a></li>
<li><a href="Dopamine" title="Dopamine">Dopamine</a></li>
<li><a href="Ebalzotan" title="Ebalzotan">Ebalzotan</a></li>
<li><a href="Eltoprazine" title="Eltoprazine">Eltoprazine</a></li>
<li><a href="Enciprazine" title="Enciprazine">Enciprazine</a></li>
<li><a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="Bromocriptine" title="Bromocriptine">bromocriptine</a>, <a href="Cabergoline" title="Cabergoline">cabergoline</a>, <a href="Dihydroergotamine" title="Dihydroergotamine">dihydroergotamine</a>, <a href="Ergotamine" title="Ergotamine">ergotamine</a>, <a href="Lisuride" title="Lisuride">lisuride</a>, <a href="LSD" title="LSD">LSD</a>, <a href="Methylergometrine" title="Methylergometrine">methylergometrine (methylergonovine)</a>, <a href="Methysergide" title="Methysergide">methysergide</a>, <a href="Pergolide" title="Pergolide">pergolide</a>)</li>
<li><a href="F-11461" title="F-11461">F-11461</a></li>
<li>F-12826</li>
<li>F-13714</li>
<li>F-14679</li>
<li><a href="F-15063" title="F-15063">F-15063</a></li>
<li><a href="F-15599" title="F-15599">F-15599</a></li>
<li><a href="Flesinoxan" title="Flesinoxan">Flesinoxan</a></li>
<li><a href="Flibanserin" title="Flibanserin">Flibanserin</a></li>
<li><a href="Flumexadol" title="Flumexadol">Flumexadol</a></li>
<li><a href="Hypidone" title="Hypidone">Hypidone</a></li>
<li><a href="Lesopitron" title="Lesopitron">Lesopitron</a></li>
<li><a href="LY-293284" title="LY-293284">LY-293284</a></li>
<li>LY-301317</li>
<li><a href="Meta-Chlorophenylpiperazine" title="Meta-Chlorophenylpiperazine">mCPP</a></li>
<li><a href="Osemozotan" title="Osemozotan">MKC-242</a></li>
<li><a href="Naluzotan" title="Naluzotan">Naluzotan</a></li>
<li><a href="NBUMP" title="NBUMP">NBUMP</a></li>
<li><a href="Osemozotan" title="Osemozotan">Osemozotan</a></li>
<li><a href="Oxaflozane" title="Oxaflozane">Oxaflozane</a></li>
<li><a href="Pardoprunox" title="Pardoprunox">Pardoprunox</a></li>
<li><a href="Piclozotan" title="Piclozotan">Piclozotan</a></li>
<li><a href="Rauwolscine" title="Rauwolscine">Rauwolscine</a></li>
<li><a href="Repinotan" title="Repinotan">Repinotan</a></li>
<li><a href="Roxindole" title="Roxindole">Roxindole</a></li>
<li><a href="RU-24969" title="RU-24969">RU-24969</a></li>
<li><a href="S-14506" title="S-14506">S-14506</a></li>
<li><a href="S-14671" title="S-14671">S-14671</a></li>
<li><a href="S-15535" title="S-15535">S-15535</a></li>
<li><a href="Sarizotan" title="Sarizotan">Sarizotan</a></li>
<li><a href="Serotonin" title="Serotonin">Serotonin (5-HT)</a></li>
<li>SSR-181507</li>
<li><a href="Sunepitron" title="Sunepitron">Sunepitron</a></li>
<li><a href="Substituted_tryptamine" title="Substituted tryptamine">Tryptamines</a> (e.g., <a href="5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a>, <a href="5-MeO-DMT" title="5-MeO-DMT">5-MeO-DMT</a>, <a href="5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a>, <a href="Bufotenin" title="Bufotenin">bufotenin</a>, <a href="N%2CN-Dimethyltryptamine" class="mw-redirect" title="N,N-Dimethyltryptamine">DMT</a>, <a href="Indorenate" title="Indorenate">indorenate</a>, <a href="N-Methylserotonin" title="N-Methylserotonin">N-Me-5-HT</a>, <a href="Psilocin" title="Psilocin">psilocin</a>, <a href="Psilocybin" title="Psilocybin">psilocybin</a>)</li>
<li><a href="TGBA01AD" title="TGBA01AD">TGBA01AD</a></li>
<li><a href="U-92016-A" title="U-92016-A">U-92016-A</a></li>
<li><a href="Urapidil" title="Urapidil">Urapidil</a></li>
<li><a href="Vilazodone" title="Vilazodone">Vilazodone</a></li>
<li><a href="Xaliproden" title="Xaliproden">Xaliproden</a></li>
<li><a href="Yohimbine" title="Yohimbine">Yohimbine</a></li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Positive allosteric modulators:</i> <a href="Oleamide" title="Oleamide">Oleamide</a></li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Antagonists:</i> <a href="Atypical_antipsychotic" title="Atypical antipsychotic">Atypical antipsychotics</a> (e.g., <a href="Iloperidone" title="Iloperidone">iloperidone</a>, <a href="Risperidone" title="Risperidone">risperidone</a>, <a href="Sertindole" title="Sertindole">sertindole</a>)</li>
<li><a href="AV965" title="AV965">AV965</a></li>
<li><a href="Beta_blocker" title="Beta blocker">Beta blockers</a> (e.g., <a href="Alprenolol" title="Alprenolol">alprenolol</a>, <a href="Carteolol" title="Carteolol">carteolol</a>, <a href="Cyanopindolol" title="Cyanopindolol">cyanopindolol</a>, <a href="Iodocyanopindolol" title="Iodocyanopindolol">iodocyanopindolol</a>, <a href="Isamoltane" title="Isamoltane">isamoltane</a>, <a href="Oxprenolol" title="Oxprenolol">oxprenolol</a>, <a href="Penbutolol" title="Penbutolol">penbutolol</a>, <a href="Pindobind" title="Pindobind">pindobind</a>, <a href="Pindolol" title="Pindolol">pindolol</a>, <a href="Propranolol" title="Propranolol">propranolol</a>, <a href="Tertatolol" title="Tertatolol">tertatolol</a>)</li>
<li><a href="BMY-7378" title="BMY-7378">BMY-7378</a></li>
<li><a href="CSP-2503" title="CSP-2503">CSP-2503</a></li>
<li><a href="Dotarizine" title="Dotarizine">Dotarizine</a></li>
<li><a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="Metergoline" title="Metergoline">metergoline</a>)</li>
<li>FCE-24379</li>
<li><a href="Flopropione" title="Flopropione">Flopropione</a></li>
<li>GR-46611</li>
<li><a href="Isamoltane" title="Isamoltane">Isamoltane</a></li>
<li><a href="Lecozotan" title="Lecozotan">Lecozotan</a></li>
<li><a href="Mefway_(18F)" title="Mefway (18F)">Mefway</a></li>
<li><a href="Metitepine" title="Metitepine">Metitepine (methiothepin)</a></li>
<li><a href="MIN-117" title="MIN-117">MIN-117 (WF-516)</a></li>
<li><a href="MPPF" title="MPPF">MPPF</a></li>
<li><a href="NAN-190" title="NAN-190">NAN-190</a></li>
<li><a href="Robalzotan" title="Robalzotan">Robalzotan</a></li>
<li><a href="S-15535" title="S-15535">S-15535</a></li>
<li><a href="SB-649915" title="SB-649915">SB-649915</a></li>
<li>SDZ 216-525</li>
<li><a href="Spiperone" title="Spiperone">Spiperone</a></li>
<li><a href="Spiramide" title="Spiramide">Spiramide</a></li>
<li><a href="Spiroxatrine" title="Spiroxatrine">Spiroxatrine</a></li>
<li><a href="UH-301" title="UH-301">UH-301</a></li>
<li><a href="WAY-100135" title="WAY-100135">WAY-100135</a></li>
<li><a href="WAY-100635" title="WAY-100635">WAY-100635</a></li>
<li><a href="Xylamidine" title="Xylamidine">Xylamidine</a></li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Unknown/unsorted:</i> <a href="Acetryptine" title="Acetryptine">Acetryptine</a></li>
<li><a href="Carvedilol" title="Carvedilol">Carvedilol</a></li>
<li><a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="Ergometrine" class="mw-redirect" title="Ergometrine">ergometrine (ergonovine)</a>)</li></ul>
</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="5-HT1B_receptor" title="5-HT1B receptor">5-HT<sub>1B</sub></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Agonists:</i> <a href="Anpirtoline" title="Anpirtoline">Anpirtoline</a></li>
<li><a href="CGS-12066A" title="CGS-12066A">CGS-12066A</a></li>
<li><a href="CP-93129" title="CP-93129">CP-93129</a></li>
<li><a href="CP-94253" title="CP-94253">CP-94253</a></li>
<li><a href="CP-122288" title="CP-122288">CP-122288</a></li>
<li><a href="CP-135807" title="CP-135807">CP-135807</a></li>
<li><a href="Eltoprazine" title="Eltoprazine">Eltoprazine</a></li>
<li><a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="Bromocriptine" title="Bromocriptine">bromocriptine</a>, <a href="Dihydroergotamine" title="Dihydroergotamine">dihydroergotamine</a>, <a href="Ergotamine" title="Ergotamine">ergotamine</a>, <a href="Methylergometrine" title="Methylergometrine">methylergometrine (methylergonovine)</a>, <a href="Methysergide" title="Methysergide">methysergide</a>, <a href="Pergolide" title="Pergolide">pergolide</a>)</li>
<li><a href="Meta-Chlorophenylpiperazine" title="Meta-Chlorophenylpiperazine">mCPP</a></li>
<li><a href="RU-24969" title="RU-24969">RU-24969</a></li>
<li><a href="Serotonin" title="Serotonin">Serotonin (5-HT)</a></li>
<li><a href="Triptan" title="Triptan">Triptans</a> (e.g., <a href="Avitriptan" title="Avitriptan">avitriptan</a>, <a href="Donitriptan" title="Donitriptan">donitriptan</a>, <a href="Eletriptan" title="Eletriptan">eletriptan</a>, <a href="Sumatriptan" title="Sumatriptan">sumatriptan</a>, )</li>
<li><a href="Trifluoromethylphenylpiperazine" title="Trifluoromethylphenylpiperazine">TFMPP</a></li>
<li><a href="Substituted_tryptamine" title="Substituted tryptamine">Tryptamines</a> (e.g., <a href="5-Benzyloxytryptamine" title="5-Benzyloxytryptamine">5-BT</a>, <a href="5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a>, <a href="5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a>, <a href="N%2CN-Dimethyltryptamine" class="mw-redirect" title="N,N-Dimethyltryptamine">DMT</a>)</li>
<li><a href="Vortioxetine" title="Vortioxetine">Vortioxetine</a></li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Antagonists:</i> <a href="AR-A000002" title="AR-A000002">AR-A000002</a></li>
<li><a href="Beta_blocker" title="Beta blocker">Beta blockers</a> (e.g., <a href="Alprenolol" title="Alprenolol">alprenolol</a>, <a href="Carteolol" title="Carteolol">carteolol</a>, <a href="Isamoltane" title="Isamoltane">isamoltane</a>, <a href="Oxprenolol" title="Oxprenolol">oxprenolol</a>, <a href="Penbutolol" title="Penbutolol">penbutolol</a>, <a href="Propranolol" title="Propranolol">propranolol</a>, <a href="Tertatolol" title="Tertatolol">tertatolol</a>)</li>
<li><a href="Elzasonan" title="Elzasonan">Elzasonan</a></li>
<li><a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="Metergoline" title="Metergoline">metergoline</a>)</li>
<li><a href="GR-127935" title="GR-127935">GR-127935</a></li>
<li><a href="Isamoltane" title="Isamoltane">Isamoltane</a></li>
<li><a href="LY-393558" title="LY-393558">LY-393558</a></li>
<li><a href="Metitepine" title="Metitepine">Metitepine (methiothepin)</a></li>
<li><a href="SB-216641" title="SB-216641">SB-216641</a></li>
<li><a href="SB-224289" title="SB-224289">SB-224289</a></li>
<li><a href="SB-236057" title="SB-236057">SB-236057</a></li>
<li><a href="Yohimbine" title="Yohimbine">Yohimbine</a></li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Unknown/unsorted:</i> <a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="Cabergoline" title="Cabergoline">cabergoline</a>, <a href="Ergometrine" class="mw-redirect" title="Ergometrine">ergometrine (ergonovine)</a>, <a href="Lisuride" title="Lisuride">lisuride</a>)</li></ul>
</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="5-HT1D_receptor" title="5-HT1D receptor">5-HT<sub>1D</sub></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Agonists:</i> <a href="CP-122288" title="CP-122288">CP-122288</a></li>
<li><a href="CP-135807" title="CP-135807">CP-135807</a></li>
<li>CP-286601</li>
<li><a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="Bromocriptine" title="Bromocriptine">bromocriptine</a>, <a href="Cabergoline" title="Cabergoline">cabergoline</a>, <a href="Dihydroergotamine" title="Dihydroergotamine">dihydroergotamine</a>, <a href="Ergotamine" title="Ergotamine">ergotamine</a>, <a href="LSD" title="LSD">LSD</a>, <a href="Methysergide" title="Methysergide">methysergide</a>)</li>
<li>GR-46611</li>
<li><a href="L-694247" title="L-694247">L-694247</a></li>
<li>L-772405</li>
<li><a href="Meta-Chlorophenylpiperazine" title="Meta-Chlorophenylpiperazine">mCPP</a></li>
<li>PNU-109291</li>
<li><a href="PNU-142633" title="PNU-142633">PNU-142633</a></li>
<li><a href="Serotonin" title="Serotonin">Serotonin (5-HT)</a></li>
<li><a href="TGBA01AD" title="TGBA01AD">TGBA01AD</a></li>
<li><a href="Triptan" title="Triptan">Triptans</a> (e.g., <a href="Almotriptan" title="Almotriptan">almotriptan</a>, <a href="Avitriptan" title="Avitriptan">avitriptan</a>, <a href="Donitriptan" title="Donitriptan">donitriptan</a>, <a href="Eletriptan" title="Eletriptan">eletriptan</a>, <a href="Frovatriptan" title="Frovatriptan">frovatriptan</a>, <a href="Naratriptan" title="Naratriptan">naratriptan</a>, <a href="Rizatriptan" title="Rizatriptan">rizatriptan</a>, <a href="Sumatriptan" title="Sumatriptan">sumatriptan</a>, )</li>
<li><a href="Substituted_tryptamine" title="Substituted tryptamine">Tryptamines</a> (e.g., <a href="5-Benzyloxytryptamine" title="5-Benzyloxytryptamine">5-BT</a>, <a href="5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a>, <a href="5-Ethyl-DMT" title="5-Ethyl-DMT">5-Et-DMT</a>, <a href="5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a>, <a href="5-(Nonyloxy)tryptamine" title="5-(Nonyloxy)tryptamine">5-(nonyloxy)tryptamine</a>, <a href="N%2CN-Dimethyltryptamine" class="mw-redirect" title="N,N-Dimethyltryptamine">DMT</a>)</li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Antagonists:</i> <a href="Alniditan" title="Alniditan">Alniditan</a></li>
<li><a href="BRL-15572" title="BRL-15572">BRL-15572</a></li>
<li><a href="Elzasonan" title="Elzasonan">Elzasonan</a></li>
<li><a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="Metergoline" title="Metergoline">metergoline</a>)</li>
<li><a href="GR-127935" title="GR-127935">GR-127935</a></li>
<li><a href="Ketanserin" title="Ketanserin">Ketanserin</a></li>
<li><a href="LY-310762" title="LY-310762">LY-310762</a></li>
<li><a href="LY-367642" title="LY-367642">LY-367642</a></li>
<li><a href="LY-393558" title="LY-393558">LY-393558</a></li>
<li><a href="LY-456219" title="LY-456219">LY-456219</a></li>
<li><a href="LY-456220" title="LY-456220">LY-456220</a></li>
<li><a href="Metitepine" title="Metitepine">Metitepine (methiothepin)</a></li>
<li><a href="Mianserin" title="Mianserin">Mianserin</a></li>
<li><a href="Ritanserin" title="Ritanserin">Ritanserin</a></li>
<li><a href="Yohimbine" title="Yohimbine">Yohimbine</a></li>
<li><a href="Ziprasidone" title="Ziprasidone">Ziprasidone</a></li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Unknown/unsorted:</i> <a href="Acetryptine" title="Acetryptine">Acetryptine</a></li>
<li><a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="Lisuride" title="Lisuride">lisuride</a>, <a href="Lysergol" title="Lysergol">lysergol</a>, <a href="Pergolide" title="Pergolide">pergolide</a>)</li></ul>
</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="5-HT1E_receptor" title="5-HT1E receptor">5-HT<sub>1E</sub></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Agonists:</i> <a href="BRL-54443" title="BRL-54443">BRL-54443</a></li>
<li><a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="Methysergide" title="Methysergide">methysergide</a>)</li>
<li><a href="Serotonin" title="Serotonin">Serotonin (5-HT)</a></li>
<li><a href="Triptan" title="Triptan">Triptans</a> (e.g., <a href="Eletriptan" title="Eletriptan">eletriptan</a>)</li>
<li><a href="Substituted_tryptamine" title="Substituted tryptamine">Tryptamines</a> (e.g., <a href="Tryptamine" title="Tryptamine">tryptamine</a>)</li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Antagonists:</i> <a href="Metitepine" title="Metitepine">Metitepine (methiothepin)</a></li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Unknown/unsorted:</i> <a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="Ergometrine" class="mw-redirect" title="Ergometrine">ergometrine (ergonovine)</a>, <a href="Lysergol" title="Lysergol">lysergol</a>, <a href="Methylergometrine" title="Methylergometrine">methylergometrine (methylergonovine)</a></li></ul>
</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="5-HT1F_receptor" title="5-HT1F receptor">5-HT<sub>1F</sub></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Agonists:</i> <a href="BRL-54443" title="BRL-54443">BRL-54443</a></li>
<li><a href="CP-122288" title="CP-122288">CP-122288</a></li>
<li><a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="Bromocriptine" title="Bromocriptine">bromocriptine</a>, <a href="Lysergol" title="Lysergol">lysergol</a>, <a href="Methylergometrine" title="Methylergometrine">methylergometrine (methylergonovine)</a> <a href="Methysergide" title="Methysergide">methysergide</a>)</li>
<li><a href="Lasmiditan" title="Lasmiditan">Lasmiditan</a></li>
<li><a href="LY-334370" title="LY-334370">LY-334370</a></li>
<li><a href="LY-344864" title="LY-344864">LY-344864</a></li>
<li><a href="Serotonin" title="Serotonin">Serotonin (5-HT)</a></li>
<li><a href="Triptan" title="Triptan">Triptans</a> (e.g., <a href="Eletriptan" title="Eletriptan">eletriptan</a>, <a href="Naratriptan" title="Naratriptan">naratriptan</a>, <a href="Sumatriptan" title="Sumatriptan">sumatriptan</a>)</li>
<li><a href="Substituted_tryptamine" title="Substituted tryptamine">Tryptamines</a> (e.g., <a href="5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a>)</li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Antagonists:</i> <a href="Metitepine" title="Metitepine">Metitepine (methiothepin)</a></li>
<li><a href="Mianserin" title="Mianserin">Mianserin</a></li></ul>
</div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="5-HT2_receptor" title="5-HT2 receptor">5-HT<sub>2</sub></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="5-HT2A_receptor" title="5-HT2A receptor">5-HT<sub>2A</sub></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Agonists:</i> 25H/NB series (e.g., <a href="25I-NBF" title="25I-NBF">25I-NBF</a>, <a href="25I-NBMD" title="25I-NBMD">25I-NBMD</a>, <a href="25I-NBOH" title="25I-NBOH">25I-NBOH</a>, <a href="25I-NBOMe" title="25I-NBOMe">25I-NBOMe</a>, <a href="25B-NBOMe" title="25B-NBOMe">25B-NBOMe</a>, <a href="25C-NBOMe" title="25C-NBOMe">25C-NBOMe</a>, <a href="25TFM-NBOMe" title="25TFM-NBOMe">25TFM-NBOMe</a>, <a href="2CBCB-NBOMe" title="2CBCB-NBOMe">2CBCB-NBOMe</a>, <a href="25CN-NBOH" title="25CN-NBOH">25CN-NBOH</a>, <a href="2CBFly-NBOMe" title="2CBFly-NBOMe">2CBFly-NBOMe</a>)</li>
<li><a href="2C_(psychedelics)" title="2C (psychedelics)">2Cs</a> (e.g., <a href="2C-B" title="2C-B">2C-B</a>, <a href="2C-E" title="2C-E">2C-E</a>, <a href="2C-I" title="2C-I">2C-I</a>, <a href="2C-T-2" title="2C-T-2">2C-T-2</a>, <a href="2C-T-7" title="2C-T-7">2C-T-7</a>, <a href="2C-T-21" title="2C-T-21">2C-T-21</a>)</li>
<li><a href="2C-B-FLY" title="2C-B-FLY">2C-B-FLY</a></li>
<li><a href="2CB-Ind" title="2CB-Ind">2CB-Ind</a></li>
<li><a href="5-Methoxytryptamine" title="5-Methoxytryptamine">5-Methoxytryptamines</a> (<a href="5-MeO-DET" title="5-MeO-DET">5-MeO-DET</a>, <a href="5-Methoxy-N%2CN-diisopropyltryptamine" class="mw-redirect" title="5-Methoxy-N,N-diisopropyltryptamine">5-MeO-DiPT</a>, <a href="5-MeO-DMT" title="5-MeO-DMT">5-MeO-DMT</a>, <a href="5-MeO-DPT" title="5-MeO-DPT">5-MeO-DPT</a>, <a href="5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a>)</li>
<li><a href="Substituted_alpha-alkyltryptamine" class="mw-redirect" title="Substituted alpha-alkyltryptamine">α-Alkyltryptamines</a> (e.g., <a href="5-Chloro-%CE%B1MT" title="5-Chloro-αMT">5-Cl-αMT</a>, <a href="5-Fluoro-AMT" title="5-Fluoro-AMT">5-Fl-αMT</a>, <a href="5-MeO-AET" title="5-MeO-AET">5-MeO-αET</a>, <a href="5-MeO-aMT" class="mw-redirect" title="5-MeO-aMT">5-MeO-αMT</a>, <a href="Alpha-Methylserotonin" class="mw-redirect" title="Alpha-Methylserotonin">α-Me-5-HT</a>, <a href="Alpha-Ethyltryptamine" class="mw-redirect" title="Alpha-Ethyltryptamine">αET</a>, <a href="Alpha-Methyltryptamine" class="mw-redirect" title="Alpha-Methyltryptamine">αMT</a>)</li>
<li><a href="AL-34662" title="AL-34662">AL-34662</a></li>
<li><a href="AL-37350A" title="AL-37350A">AL-37350A</a></li>
<li><a href="Bromo-DragonFLY" title="Bromo-DragonFLY">Bromo-DragonFLY</a></li>
<li><a href="Dimemebfe" title="Dimemebfe">Dimemebfe</a></li>
<li><a href="DMBMPP" title="DMBMPP">DMBMPP</a></li>
<li><a href="DOx" title="DOx">DOx</a> (e.g., <a href="2%2C5-Dimethoxy-4-bromoamphetamine" title="2,5-Dimethoxy-4-bromoamphetamine">DOB</a>, <a href="2%2C5-Dimethoxy-4-chloroamphetamine" title="2,5-Dimethoxy-4-chloroamphetamine">DOC</a>, <a href="2%2C5-Dimethoxy-4-iodoamphetamine" title="2,5-Dimethoxy-4-iodoamphetamine">DOI</a>, <a href="2%2C5-Dimethoxy-4-methylamphetamine" title="2,5-Dimethoxy-4-methylamphetamine">DOM</a>)</li>
<li><a href="Efavirenz" title="Efavirenz">Efavirenz</a></li>
<li><a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="1P-LSD" title="1P-LSD">1P-LSD</a>, <a href="ALD-52" title="ALD-52">ALD-52</a>, <a href="Bromocriptine" title="Bromocriptine">bromocriptine</a>, <a href="Cabergoline" title="Cabergoline">cabergoline</a>, <a href="Ergine" title="Ergine">ergine (LSA)</a>, <a href="Ergometrine" class="mw-redirect" title="Ergometrine">ergometrine (ergonovine)</a>, <a href="Ergotamine" title="Ergotamine">ergotamine</a>, <a href="Lisuride" title="Lisuride">lisuride</a>, <a href="Lysergic_acid_2%2C4-dimethylazetidide" title="Lysergic acid 2,4-dimethylazetidide">LA-SS-Az</a>, <a href="Lysergic_acid_2-butyl_amide" title="Lysergic acid 2-butyl amide">LSB</a>, <a href="LSD" title="LSD">LSD</a>, <a href="LSD-Pip" class="mw-redirect" title="LSD-Pip">LSD-Pip</a>, <a href="Lysergic_acid_hydroxyethylamide" title="Lysergic acid hydroxyethylamide">LSH</a>, <a href="Lysergic_acid_3-pentyl_amide" title="Lysergic acid 3-pentyl amide">LSP</a>, <a href="Methylergometrine" title="Methylergometrine">methylergometrine (methylergonovine)</a>, <a href="Pergolide" title="Pergolide">pergolide</a>)</li>
<li><a href="Flumexadol" title="Flumexadol">Flumexadol</a></li>
<li><a href="IHCH-7113" title="IHCH-7113">IHCH-7113</a></li>
<li><a href="Jimscaline" title="Jimscaline">Jimscaline</a></li>
<li><a href="Lorcaserin" title="Lorcaserin">Lorcaserin</a></li>
<li><a href="Substituted_methylenedioxyphenethylamine" title="Substituted methylenedioxyphenethylamine">MDxx</a> (e.g., <a href="3%2C4-Methylenedioxyamphetamine" title="3,4-Methylenedioxyamphetamine">MDA (tenamfetamine)</a>, <a href="MDMA" title="MDMA">MDMA (midomafetamine)</a>, <a href="3%2C4-Methylenedioxy-N-hydroxyamphetamine" title="3,4-Methylenedioxy-N-hydroxyamphetamine">MDOH</a>, <a href="MMDA_(drug)" title="MMDA (drug)">MMDA</a>)</li>
<li><a href="O-4310" title="O-4310">O-4310</a></li>
<li><a href="Oxaflozane" title="Oxaflozane">Oxaflozane</a></li>
<li><a href="PHA-57378" title="PHA-57378">PHA-57378</a></li>
<li><a href="PNU-22394" title="PNU-22394">PNU-22394</a></li>
<li><a href="PNU-181731" title="PNU-181731">PNU-181731</a></li>
<li><a href="RH-34" title="RH-34">RH-34</a></li>
<li><a href="SCHEMBL5334361" title="SCHEMBL5334361">SCHEMBL5334361</a></li>
<li><a href="Substituted_phenethylamine" title="Substituted phenethylamine">Phenethylamines</a> (e.g., <a href="Lophophine" title="Lophophine">lophophine</a>, <a href="Mescaline" title="Mescaline">mescaline</a>)</li>
<li><a href="Piperazine" title="Piperazine">Piperazines</a> (e.g., <a href="Benzylpiperazine" title="Benzylpiperazine">BZP</a>, <a href="Quipazine" title="Quipazine">quipazine</a>, <a href="Trifluoromethylphenylpiperazine" title="Trifluoromethylphenylpiperazine">TFMPP</a>)</li>
<li><a href="Serotonin" title="Serotonin">Serotonin (5-HT)</a></li>
<li><a href="TCB-2" title="TCB-2">TCB-2</a></li>
<li><a href="TFMFly" title="TFMFly">TFMFly</a></li>
<li><a href="Substituted_tryptamine" title="Substituted tryptamine">Tryptamines</a> (e.g., <a href="5-Benzyloxytryptamine" title="5-Benzyloxytryptamine">5-BT</a>, <a href="5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a>, <a href="Bufotenin" title="Bufotenin">bufotenin</a>, <a href="Diethyltryptamine" title="Diethyltryptamine">DET</a>, <a href="Diisopropyltryptamine" class="mw-redirect" title="Diisopropyltryptamine">DiPT</a>, <a href="N%2CN-Dimethyltryptamine" class="mw-redirect" title="N,N-Dimethyltryptamine">DMT</a>, <a href="Dipropyltryptamine" title="Dipropyltryptamine">DPT</a>, <a href="Psilocin" title="Psilocin">psilocin</a>, <a href="Psilocybin" title="Psilocybin">psilocybin</a>, <a href="Tryptamine" title="Tryptamine">tryptamine</a>)</li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Positive allosteric modulators:</i> <a href="CTW0404" title="CTW0404">CTW0404</a></li>
<li>CTW0419</li>
<li><a href="JPC0323" title="JPC0323">JPC0323</a></li>
<li><a href="(R)-Glaucine" class="mw-redirect" title="(R)-Glaucine">(<i>R</i>)-Glaucine</a></li>
<li><a href="Oleamide" title="Oleamide">Oleamide</a></li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Antagonists:</i> <a href="5-I-R91150" title="5-I-R91150">5-I-R91150</a></li>
<li><a href="5-MeO-NBpBrT" title="5-MeO-NBpBrT">5-MeO-NBpBrT</a></li>
<li><a href="AC-90179" title="AC-90179">AC-90179</a></li>
<li><a href="Adatanserin" title="Adatanserin">Adatanserin</a></li>
<li><a href="Altanserin" title="Altanserin">Altanserin</a></li>
<li><a href="Antihistamine" title="Antihistamine">Antihistamines</a> (e.g., <a href="Cyproheptadine" title="Cyproheptadine">cyproheptadine</a>, <a href="Hydroxyzine" title="Hydroxyzine">hydroxyzine</a>, <a href="Ketotifen" title="Ketotifen">ketotifen</a>, <a href="Perlapine" title="Perlapine">perlapine</a>)</li>
<li><a href="9-Aminomethyl-9%2C10-dihydroanthracene" title="9-Aminomethyl-9,10-dihydroanthracene">AMDA</a></li>
<li><a href="Atypical_antipsychotic" title="Atypical antipsychotic">Atypical antipsychotics</a> (e.g., <a href="Amperozide" title="Amperozide">amperozide</a>, <a href="Aripiprazole" title="Aripiprazole">aripiprazole</a>, <a href="Asenapine" title="Asenapine">asenapine</a>, <a href="Blonanserin" title="Blonanserin">blonanserin</a>, <a href="Brexpiprazole" title="Brexpiprazole">brexpiprazole</a>, <a href="Carpipramine" title="Carpipramine">carpipramine</a>, <a href="Clocapramine" title="Clocapramine">clocapramine</a>, <a href="Clorotepine" title="Clorotepine">clorotepine</a>, <a href="Clozapine" title="Clozapine">clozapine</a>, <a href="Fluperlapine" title="Fluperlapine">fluperlapine</a>, <a href="Gevotroline" title="Gevotroline">gevotroline</a>, <a href="Iloperidone" title="Iloperidone">iloperidone</a>, <a href="Lurasidone" title="Lurasidone">lurasidone</a>, <a href="Melperone" title="Melperone">melperone</a>, <a href="Mosapramine" title="Mosapramine">mosapramine</a>, <a href="Ocaperidone" title="Ocaperidone">ocaperidone</a>, <a href="Olanzapine" title="Olanzapine">olanzapine</a>, <a href="Paliperidone" title="Paliperidone">paliperidone</a>, <a href="Quetiapine" title="Quetiapine">quetiapine</a>, <a href="Risperidone" title="Risperidone">risperidone</a>, <a href="Sertindole" title="Sertindole">sertindole</a>, <a href="Zicronapine" title="Zicronapine">zicronapine</a>, <a href="Ziprasidone" title="Ziprasidone">ziprasidone</a>, <a href="Zotepine" title="Zotepine">zotepine</a>)</li>
<li><a href="Chlorprothixene" title="Chlorprothixene">Chlorprothixene</a></li>
<li><a href="Cinanserin" title="Cinanserin">Cinanserin</a></li>
<li><a href="CSP-2503" title="CSP-2503">CSP-2503</a></li>
<li><a href="Deramciclane" title="Deramciclane">Deramciclane</a></li>
<li><a href="Dotarizine" title="Dotarizine">Dotarizine</a></li>
<li><a href="Eplivanserin" title="Eplivanserin">Eplivanserin</a></li>
<li><a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="Amesergide" title="Amesergide">amesergide</a>, LY-53857, <a href="LY-215840" title="LY-215840">LY-215840</a>, <a href="Mesulergine" title="Mesulergine">mesulergine</a>, <a href="Metergoline" title="Metergoline">metergoline</a>, <a href="Methysergide" title="Methysergide">methysergide</a>, <a href="Sergolexole" title="Sergolexole">sergolexole</a>)</li>
<li><a href="Fananserin" title="Fananserin">Fananserin</a></li>
<li><a href="Flibanserin" title="Flibanserin">Flibanserin</a></li>
<li><a href="Glemanserin" title="Glemanserin">Glemanserin</a></li>
<li>Irindalone</li>
<li><a href="Ketanserin" title="Ketanserin">Ketanserin</a></li>
<li><a href="KML-010" title="KML-010">KML-010</a></li>
<li>Landipirdine</li>
<li><a href="LY-393558" title="LY-393558">LY-393558</a></li>
<li><a href="Meta-Chlorophenylpiperazine" title="Meta-Chlorophenylpiperazine">mCPP</a></li>
<li><a href="Medifoxamine" title="Medifoxamine">Medifoxamine</a></li>
<li><a href="Metitepine" title="Metitepine">Metitepine (methiothepin)</a></li>
<li><a href="MIN-117" title="MIN-117">MIN-117 (WF-516)</a></li>
<li><a href="Naftidrofuryl" title="Naftidrofuryl">Naftidrofuryl</a></li>
<li><a href="Nantenine" title="Nantenine">Nantenine</a></li>
<li><a href="Nelotanserin" title="Nelotanserin">Nelotanserin</a></li>
<li><a href="Opiranserin" title="Opiranserin">Opiranserin (VVZ-149)</a></li>
<li><a href="Pelanserin" title="Pelanserin">Pelanserin</a></li>
<li><a href="Phenoxybenzamine" title="Phenoxybenzamine">Phenoxybenzamine</a></li>
<li><a href="Pimavanserin" title="Pimavanserin">Pimavanserin</a></li>
<li><a href="Pirenperone" title="Pirenperone">Pirenperone</a></li>
<li><a href="Pizotifen" title="Pizotifen">Pizotifen</a></li>
<li><a href="Pruvanserin" title="Pruvanserin">Pruvanserin</a></li>
<li><a href="Rauwolscine" title="Rauwolscine">Rauwolscine</a></li>
<li><a href="Ritanserin" title="Ritanserin">Ritanserin</a></li>
<li><a href="Roluperidone" title="Roluperidone">Roluperidone</a></li>
<li><a href="S-14671" title="S-14671">S-14671</a></li>
<li><a href="Sarpogrelate" title="Sarpogrelate">Sarpogrelate</a></li>
<li><a href="Serotonin_antagonist_and_reuptake_inhibitor" title="Serotonin antagonist and reuptake inhibitor">Serotonin antagonists and reuptake inhibitors</a> (e.g., <a href="Etoperidone" title="Etoperidone">etoperidone</a>, <a href="Hydroxynefazodone" title="Hydroxynefazodone">hydroxynefazodone</a>, <a href="Lubazodone" title="Lubazodone">lubazodone</a>, <a href="Mepiprazole" title="Mepiprazole">mepiprazole</a>, <a href="Nefazodone" title="Nefazodone">nefazodone</a>, <a href="Triazoledione" title="Triazoledione">triazoledione</a>, <a href="Trazodone" title="Trazodone">trazodone</a>)</li>
<li>SR-46349B</li>
<li><a href="TGBA01AD" title="TGBA01AD">TGBA01AD</a></li>
<li><a href="Teniloxazine" title="Teniloxazine">Teniloxazine</a></li>
<li>Temanogrel</li>
<li><a href="Tetracyclic_antidepressant" title="Tetracyclic antidepressant">Tetracyclic antidepressants</a> (e.g., <a href="Amoxapine" title="Amoxapine">amoxapine</a>, <a href="Aptazapine" title="Aptazapine">aptazapine</a>, <a href="Esmirtazapine" title="Esmirtazapine">esmirtazapine</a>, <a href="Maprotiline" title="Maprotiline">maprotiline</a>, <a href="Mianserin" title="Mianserin">mianserin</a>, <a href="Mirtazapine" title="Mirtazapine">mirtazapine</a>)</li>
<li><a href="Tricyclic_antidepressant" title="Tricyclic antidepressant">Tricyclic antidepressants</a> (e.g., <a href="Amitriptyline" title="Amitriptyline">amitriptyline</a>)</li>
<li><a href="Typical_antipsychotic" title="Typical antipsychotic">Typical antipsychotics</a> (e.g., <a href="Chlorpromazine" title="Chlorpromazine">chlorpromazine</a>, <a href="Fluphenazine" title="Fluphenazine">fluphenazine</a>, <a href="Haloperidol" title="Haloperidol">haloperidol</a>, <a href="Loxapine" title="Loxapine">loxapine</a>, <a href="Perphenazine" title="Perphenazine">perphenazine</a>, <a href="Pimozide" title="Pimozide">pimozide</a>, <a href="Pipamperone" title="Pipamperone">pipamperone</a>, <a href="Prochlorperazine" title="Prochlorperazine">prochlorperazine</a>, <a href="Setoperone" title="Setoperone">setoperone</a>, <a href="Spiperone" title="Spiperone">spiperone</a>, <a href="Spiramide" title="Spiramide">spiramide</a>, <a href="Thioridazine" title="Thioridazine">thioridazine</a>, <a href="Tiotixene" title="Tiotixene">thiothixene</a>, <a href="Trifluoperazine" title="Trifluoperazine">trifluoperazine</a>)</li>
<li><a href="Volinanserin" title="Volinanserin">Volinanserin</a></li>
<li><a href="Xylamidine" title="Xylamidine">Xylamidine</a></li>
<li><a href="Yohimbine" title="Yohimbine">Yohimbine</a></li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Unknown/unsorted:</i> <a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="Dihydroergotamine" title="Dihydroergotamine">dihydroergotamine</a>, <a href="Nicergoline" title="Nicergoline">nicergoline</a>)</li></ul>
</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="5-HT2B_receptor" title="5-HT2B receptor">5-HT<sub>2B</sub></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Agonists:</i> <a href="4-Methylaminorex" title="4-Methylaminorex">4-Methylaminorex</a></li>
<li><a href="Aminorex" title="Aminorex">Aminorex</a></li>
<li><a href="Substituted_amphetamine" title="Substituted amphetamine">Amphetamines</a> (e.g., <a href="Chlorphentermine" title="Chlorphentermine">chlorphentermine</a>, <a href="Cloforex" title="Cloforex">cloforex</a>, <a href="Dexfenfluramine" title="Dexfenfluramine">dexfenfluramine</a>, <a href="Fenfluramine" title="Fenfluramine">fenfluramine</a>, <a href="Levofenfluramine" title="Levofenfluramine">levofenfluramine</a>, <a href="Norfenfluramine" title="Norfenfluramine">norfenfluramine</a>)</li>
<li><a href="BW-723C86" title="BW-723C86">BW-723C86</a></li>
<li><a href="DOx" title="DOx">DOx</a> (e.g., <a href="2%2C5-Dimethoxy-4-bromoamphetamine" title="2,5-Dimethoxy-4-bromoamphetamine">DOB</a>, <a href="2%2C5-Dimethoxy-4-chloroamphetamine" title="2,5-Dimethoxy-4-chloroamphetamine">DOC</a>, <a href="2%2C5-Dimethoxy-4-iodoamphetamine" title="2,5-Dimethoxy-4-iodoamphetamine">DOI</a>, <a href="2%2C5-Dimethoxy-4-methylamphetamine" title="2,5-Dimethoxy-4-methylamphetamine">DOM</a>)</li>
<li><a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="Cabergoline" title="Cabergoline">cabergoline</a>, <a href="Dihydroergocryptine" title="Dihydroergocryptine">dihydroergocryptine</a>, <a href="Dihydroergotamine" title="Dihydroergotamine">dihydroergotamine</a>, <a href="Ergotamine" title="Ergotamine">ergotamine</a>, <a href="Methylergometrine" title="Methylergometrine">methylergometrine (methylergonovine)</a>, <a href="Methysergide" title="Methysergide">methysergide</a>, <a href="Pergolide" title="Pergolide">pergolide</a>)</li>
<li><a href="Lorcaserin" title="Lorcaserin">Lorcaserin</a></li>
<li><a href="Substituted_methylenedioxyphenethylamine" title="Substituted methylenedioxyphenethylamine">MDxx</a> (e.g., <a href="3%2C4-Methylenedioxyamphetamine" title="3,4-Methylenedioxyamphetamine">MDA (tenamfetamine)</a>, <a href="MDMA" title="MDMA">MDMA (midomafetamine)</a>, <a href="3%2C4-Methylenedioxy-N-hydroxyamphetamine" title="3,4-Methylenedioxy-N-hydroxyamphetamine">MDOH</a>, <a href="MMDA_(drug)" title="MMDA (drug)">MMDA</a>)</li>
<li><a href="Substituted_piperazine" title="Substituted piperazine">Piperazines</a> (e.g., <a href="Trifluoromethylphenylpiperazine" title="Trifluoromethylphenylpiperazine">TFMPP</a>)</li>
<li><a href="PNU-22394" title="PNU-22394">PNU-22394</a></li>
<li><a href="Ro60-0175" title="Ro60-0175">Ro60-0175</a></li>
<li><a href="Serotonin" title="Serotonin">Serotonin (5-HT)</a></li>
<li><a href="Substituted_tryptamine" title="Substituted tryptamine">Tryptamines</a> (e.g., <a href="5-Benzyloxytryptamine" title="5-Benzyloxytryptamine">5-BT</a>, <a href="5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a>, <a href="5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a>, <a href="Alpha-Methylserotonin" class="mw-redirect" title="Alpha-Methylserotonin">α-Me-5-HT</a>, <a href="Bufotenin" title="Bufotenin">bufotenin</a>, <a href="Diethyltryptamine" title="Diethyltryptamine">DET</a>, <a href="Diisopropyltryptamine" class="mw-redirect" title="Diisopropyltryptamine">DiPT</a>, <a href="N%2CN-Dimethyltryptamine" class="mw-redirect" title="N,N-Dimethyltryptamine">DMT</a>, <a href="Dipropyltryptamine" title="Dipropyltryptamine">DPT</a>, <a href="Psilocin" title="Psilocin">psilocin</a>, <a href="Psilocybin" title="Psilocybin">psilocybin</a>, <a href="Tryptamine" title="Tryptamine">tryptamine</a>)</li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Antagonists:</i> <a href="Agomelatine" title="Agomelatine">Agomelatine</a></li>
<li><a href="Atypical_antipsychotic" title="Atypical antipsychotic">Atypical antipsychotics</a> (e.g., <a href="Amisulpride" title="Amisulpride">amisulpride</a>, <a href="Aripiprazole" title="Aripiprazole">aripiprazole</a>, <a href="Asenapine" title="Asenapine">asenapine</a>, <a href="Brexpiprazole" title="Brexpiprazole">brexpiprazole</a>, <a href="Cariprazine" title="Cariprazine">cariprazine</a>, <a href="Clozapine" title="Clozapine">clozapine</a>, N-desalkylquetiapine (norquetiapine), <a href="Desmethylclozapine" title="Desmethylclozapine">N-desmethylclozapine (norclozapine)</a>, <a href="Olanzapine" title="Olanzapine">olanzapine</a>, <a href="Pipamperone" title="Pipamperone">pipamperone</a>, <a href="Quetiapine" title="Quetiapine">quetiapine</a>, <a href="Risperidone" title="Risperidone">risperidone</a>, <a href="Ziprasidone" title="Ziprasidone">ziprasidone</a>)</li>
<li><a href="Cyproheptadine" title="Cyproheptadine">Cyproheptadine</a></li>
<li><a href="EGIS-7625" title="EGIS-7625">EGIS-7625</a></li>
<li><a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="Amesergide" title="Amesergide">amesergide</a>, <a href="Bromocriptine" title="Bromocriptine">bromocriptine</a>, <a href="Lisuride" title="Lisuride">lisuride</a>, LY-53857, LY-272015, <a href="Mesulergine" title="Mesulergine">mesulergine</a>)</li>
<li><a href="Ketanserin" title="Ketanserin">Ketanserin</a></li>
<li><a href="LY-393558" title="LY-393558">LY-393558</a></li>
<li><a href="Meta-Chlorophenylpiperazine" title="Meta-Chlorophenylpiperazine">mCPP</a></li>
<li><a href="Metadoxine" title="Metadoxine">Metadoxine</a></li>
<li><a href="Metitepine" title="Metitepine">Metitepine (methiothepin)</a></li>
<li><a href="Pirenperone" title="Pirenperone">Pirenperone</a></li>
<li><a href="Pizotifen" title="Pizotifen">Pizotifen</a></li>
<li><a href="Propranolol" title="Propranolol">Propranolol</a></li>
<li><a href="PRX-08066" title="PRX-08066">PRX-08066</a></li>
<li><a href="Rauwolscine" title="Rauwolscine">Rauwolscine</a></li>
<li><a href="Ritanserin" title="Ritanserin">Ritanserin</a></li>
<li><a href="RS-127445" title="RS-127445">RS-127445</a></li>
<li><a href="Sarpogrelate" title="Sarpogrelate">Sarpogrelate</a></li>
<li><a href="SB-200646" title="SB-200646">SB-200646</a></li>
<li><a href="SB-204741" title="SB-204741">SB-204741</a></li>
<li><a href="SB-206553" title="SB-206553">SB-206553</a></li>
<li><a href="SB-215505" title="SB-215505">SB-215505</a></li>
<li><a href="SB-221284" title="SB-221284">SB-221284</a></li>
<li><a href="SB-228357" title="SB-228357">SB-228357</a></li>
<li><a href="SDZ_SER-082" title="SDZ SER-082">SDZ SER-082</a></li>
<li><a href="Tegaserod" title="Tegaserod">Tegaserod</a></li>
<li><a href="Tetracyclic_antidepressant" title="Tetracyclic antidepressant">Tetracyclic antidepressants</a> (e.g., <a href="Amoxapine" title="Amoxapine">amoxapine</a>, <a href="Mianserin" title="Mianserin">mianserin</a>, <a href="Mirtazapine" title="Mirtazapine">mirtazapine</a>)</li>
<li><a href="Trazodone" title="Trazodone">Trazodone</a></li>
<li><a href="Typical_antipsychotic" title="Typical antipsychotic">Typical antipsychotics</a> (e.g., <a href="Chlorpromazine" title="Chlorpromazine">chlorpromazine</a>)</li>
<li><a href="TIK-301" title="TIK-301">TIK-301</a></li>
<li><a href="Yohimbine" title="Yohimbine">Yohimbine</a></li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Unknown/unsorted:</i> <a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="Ergometrine" class="mw-redirect" title="Ergometrine">ergometrine (ergonovine)</a>)</li></ul>
</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="5-HT2C_receptor" title="5-HT2C receptor">5-HT<sub>2C</sub></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Agonists:</i> <a href="2C_(psychedelics)" title="2C (psychedelics)">2Cs</a> (e.g., <a href="2C-B" title="2C-B">2C-B</a>, <a href="2C-E" title="2C-E">2C-E</a>, <a href="2C-I" title="2C-I">2C-I</a>, <a href="2C-T-2" title="2C-T-2">2C-T-2</a>, <a href="2C-T-7" title="2C-T-7">2C-T-7</a>, <a href="2C-T-21" title="2C-T-21">2C-T-21</a>)</li>
<li><a href="5-Methoxytryptamine" title="5-Methoxytryptamine">5-Methoxytryptamines</a> (<a href="5-MeO-DET" title="5-MeO-DET">5-MeO-DET</a>, <a href="5-Methoxy-N%2CN-diisopropyltryptamine" class="mw-redirect" title="5-Methoxy-N,N-diisopropyltryptamine">5-MeO-DiPT</a>, <a href="5-MeO-DMT" title="5-MeO-DMT">5-MeO-DMT</a>, <a href="5-MeO-DPT" title="5-MeO-DPT">5-MeO-DPT</a>, <a href="5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a>)</li>
<li><a href="Substituted_alpha-alkyltryptamine" class="mw-redirect" title="Substituted alpha-alkyltryptamine">α-Alkyltryptamines</a> (e.g., <a href="5-Chloro-%CE%B1MT" title="5-Chloro-αMT">5-Cl-αMT</a>, <a href="5-Fluoro-AMT" title="5-Fluoro-AMT">5-Fl-αMT</a>, <a href="5-MeO-AET" title="5-MeO-AET">5-MeO-αET</a>, <a href="5-MeO-aMT" class="mw-redirect" title="5-MeO-aMT">5-MeO-αMT</a>, <a href="Alpha-Methylserotonin" class="mw-redirect" title="Alpha-Methylserotonin">α-Me-5-HT</a>, <a href="Alpha-Ethyltryptamine" class="mw-redirect" title="Alpha-Ethyltryptamine">αET</a>, <a href="Alpha-Methyltryptamine" class="mw-redirect" title="Alpha-Methyltryptamine">αMT</a>)</li>
<li><a href="A-372159" title="A-372159">A-372159</a></li>
<li><a href="AL-38022A" title="AL-38022A">AL-38022A</a></li>
<li><a href="Alstonine" title="Alstonine">Alstonine</a></li>
<li><a href="CP-809101" title="CP-809101">CP-809101</a></li>
<li><a href="Dimemebfe" title="Dimemebfe">Dimemebfe</a></li>
<li><a href="DOx" title="DOx">DOx</a> (e.g., <a href="2%2C5-Dimethoxy-4-bromoamphetamine" title="2,5-Dimethoxy-4-bromoamphetamine">DOB</a>, <a href="2%2C5-Dimethoxy-4-chloroamphetamine" title="2,5-Dimethoxy-4-chloroamphetamine">DOC</a>, <a href="2%2C5-Dimethoxy-4-iodoamphetamine" title="2,5-Dimethoxy-4-iodoamphetamine">DOI</a>, <a href="2%2C5-Dimethoxy-4-methylamphetamine" title="2,5-Dimethoxy-4-methylamphetamine">DOM</a>)</li>
<li><a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="ALD-52" title="ALD-52">ALD-52</a>, <a href="Cabergoline" title="Cabergoline">cabergoline</a>, <a href="Dihydroergotamine" title="Dihydroergotamine">dihydroergotamine</a>, <a href="Ergine" title="Ergine">ergine (LSA)</a>, <a href="Ergotamine" title="Ergotamine">ergotamine</a>, <a href="Lisuride" title="Lisuride">lisuride</a>, <a href="Lysergic_acid_2%2C4-dimethylazetidide" title="Lysergic acid 2,4-dimethylazetidide">LA-SS-Az</a>, <a href="Lysergic_acid_2-butyl_amide" title="Lysergic acid 2-butyl amide">LSB</a>, <a href="LSD" title="LSD">LSD</a>, <a href="LSD-Pip" class="mw-redirect" title="LSD-Pip">LSD-Pip</a>, <a href="Lysergic_acid_hydroxyethylamide" title="Lysergic acid hydroxyethylamide">LSH</a>, <a href="Lysergic_acid_3-pentyl_amide" title="Lysergic acid 3-pentyl amide">LSP</a>, <a href="Pergolide" title="Pergolide">pergolide</a>)</li>
<li><a href="Flumexadol" title="Flumexadol">Flumexadol</a></li>
<li><a href="Lorcaserin" title="Lorcaserin">Lorcaserin</a></li>
<li><a href="Substituted_methylenedioxyphenethylamine" title="Substituted methylenedioxyphenethylamine">MDxx</a> (e.g., <a href="3%2C4-Methylenedioxyamphetamine" title="3,4-Methylenedioxyamphetamine">MDA (tenamfetamine)</a>, <a href="MDMA" title="MDMA">MDMA (midomafetamine)</a>, <a href="3%2C4-Methylenedioxy-N-hydroxyamphetamine" title="3,4-Methylenedioxy-N-hydroxyamphetamine">MDOH</a>, <a href="MMDA_(drug)" title="MMDA (drug)">MMDA</a>)</li>
<li><a href="MK-212" title="MK-212">MK-212</a></li>
<li><a href="ORG-12962" title="ORG-12962">ORG-12962</a></li>
<li><a href="ORG-37684" title="ORG-37684">ORG-37684</a></li>
<li><a href="Oxaflozane" title="Oxaflozane">Oxaflozane</a></li>
<li><a href="PHA-57378" title="PHA-57378">PHA-57378</a></li>
<li><a href="Substituted_phenethylamine" title="Substituted phenethylamine">Phenethylamines</a> (e.g., <a href="Lophophine" title="Lophophine">lophophine</a>, <a href="Mescaline" title="Mescaline">mescaline</a>)</li>
<li><a href="Piperazine" title="Piperazine">Piperazines</a> (e.g., <a href="Aripiprazole" title="Aripiprazole">aripiprazole</a>, <a href="Benzylpiperazine" title="Benzylpiperazine">BZP</a>, <a href="Meta-Chlorophenylpiperazine" title="Meta-Chlorophenylpiperazine">mCPP</a>, <a href="Quipazine" title="Quipazine">quipazine</a>, <a href="Trifluoromethylphenylpiperazine" title="Trifluoromethylphenylpiperazine">TFMPP</a>)</li>
<li><a href="PNU-22394" title="PNU-22394">PNU-22394</a></li>
<li><a href="PNU-181731" title="PNU-181731">PNU-181731</a></li>
<li><a href="Ro60-0175" title="Ro60-0175">Ro60-0175</a></li>
<li><a href="Ro60-0213" title="Ro60-0213">Ro60-0213</a></li>
<li><a href="Serotonin" title="Serotonin">Serotonin (5-HT)</a></li>
<li><a href="Substituted_tryptamine" title="Substituted tryptamine">Tryptamines</a> (e.g., <a href="5-Benzyloxytryptamine" title="5-Benzyloxytryptamine">5-BT</a>, <a href="5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a>, <a href="Bufotenin" title="Bufotenin">bufotenin</a>, <a href="Diethyltryptamine" title="Diethyltryptamine">DET</a>, <a href="Diisopropyltryptamine" class="mw-redirect" title="Diisopropyltryptamine">DiPT</a>, <a href="N%2CN-Dimethyltryptamine" class="mw-redirect" title="N,N-Dimethyltryptamine">DMT</a>, <a href="Dipropyltryptamine" title="Dipropyltryptamine">DPT</a>, <a href="Psilocin" title="Psilocin">psilocin</a>, <a href="Psilocybin" title="Psilocybin">psilocybin</a>, <a href="Tryptamine" title="Tryptamine">tryptamine</a>)</li>
<li><a href="Vabicaserin" title="Vabicaserin">Vabicaserin</a></li>
<li><a href="WAY-629" title="WAY-629">WAY-629</a></li>
<li><a href="WAY-161503" title="WAY-161503">WAY-161503</a></li>
<li><a href="YM-348" title="YM-348">YM-348</a></li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Positive allosteric modulators:</i> <a href="CTW0415" title="CTW0415">CTW0415</a></li>
<li>CYD-1-79</li>
<li><a href="JPC0323" title="JPC0323">JPC0323</a></li>
<li><a href="Oleamide" title="Oleamide">Oleamide</a></li>
<li>PNU-69176E</li>
<li><a href="VA012" title="VA012">VA012</a></li>
<li>VA240</li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Antagonists:</i> <a href="Adatanserin" title="Adatanserin">Adatanserin</a></li>
<li><a href="Agomelatine" title="Agomelatine">Agomelatine</a></li>
<li><a href="Atypical_antipsychotic" title="Atypical antipsychotic">Atypical antipsychotics</a> (e.g., <a href="Asenapine" title="Asenapine">asenapine</a>, <a href="Clorotepine" title="Clorotepine">clorotepine</a>, <a href="Clozapine" title="Clozapine">clozapine</a>, <a href="Fluperlapine" title="Fluperlapine">fluperlapine</a>, <a href="Iloperidone" title="Iloperidone">iloperidone</a>, <a href="Melperone" title="Melperone">melperone</a>, <a href="Olanzapine" title="Olanzapine">olanzapine</a>, <a href="Paliperidone" title="Paliperidone">paliperidone</a>, <a href="Quetiapine" title="Quetiapine">quetiapine</a>, <a href="Risperidone" title="Risperidone">risperidone</a>, <a href="Sertindole" title="Sertindole">sertindole</a>, <a href="Ziprasidone" title="Ziprasidone">ziprasidone</a>, <a href="Zotepine" title="Zotepine">zotepine</a>)</li>
<li><a href="Captodiame" title="Captodiame">Captodiame</a></li>
<li><a href="6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide" title="6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide">CEPC</a></li>
<li><a href="Cinanserin" title="Cinanserin">Cinanserin</a></li>
<li><a href="Cyproheptadine" title="Cyproheptadine">Cyproheptadine</a></li>
<li><a href="Deramciclane" title="Deramciclane">Deramciclane</a></li>
<li><a href="Desmetramadol" title="Desmetramadol">Desmetramadol</a></li>
<li><a href="Dotarizine" title="Dotarizine">Dotarizine</a></li>
<li><a href="Eltoprazine" title="Eltoprazine">Eltoprazine</a></li>
<li><a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="Amesergide" title="Amesergide">amesergide</a>, <a href="Bromocriptine" title="Bromocriptine">bromocriptine</a>, LY-53857, <a href="LY-215840" title="LY-215840">LY-215840</a>, <a href="Mesulergine" title="Mesulergine">mesulergine</a>, <a href="Metergoline" title="Metergoline">metergoline</a>, <a href="Methysergide" title="Methysergide">methysergide</a>, <a href="Sergolexole" title="Sergolexole">sergolexole</a>)</li>
<li><a href="Etoperidone" title="Etoperidone">Etoperidone</a></li>
<li><a href="Fluoxetine" title="Fluoxetine">Fluoxetine</a></li>
<li>FR-260010</li>
<li>Irindalone</li>
<li><a href="Ketanserin" title="Ketanserin">Ketanserin</a></li>
<li><a href="Ketotifen" title="Ketotifen">Ketotifen</a></li>
<li><a href="Latrepirdine" title="Latrepirdine">Latrepirdine (dimebolin)</a></li>
<li><a href="Medifoxamine" title="Medifoxamine">Medifoxamine</a></li>
<li><a href="Metitepine" title="Metitepine">Metitepine (methiothepin)</a></li>
<li><a href="Nefazodone" title="Nefazodone">Nefazodone</a></li>
<li><a href="Pirenperone" title="Pirenperone">Pirenperone</a></li>
<li><a href="Pizotifen" title="Pizotifen">Pizotifen</a></li>
<li><a href="Propranolol" title="Propranolol">Propranolol</a></li>
<li><a href="Ritanserin" title="Ritanserin">Ritanserin</a></li>
<li><a href="RS-102221" title="RS-102221">RS-102221</a></li>
<li><a href="S-14671" title="S-14671">S-14671</a></li>
<li><a href="SB-200646" title="SB-200646">SB-200646</a></li>
<li><a href="SB-206553" title="SB-206553">SB-206553</a></li>
<li><a href="SB-221284" title="SB-221284">SB-221284</a></li>
<li><a href="SB-228357" title="SB-228357">SB-228357</a></li>
<li><a href="SB-242084" title="SB-242084">SB-242084</a></li>
<li><a href="SB-243213" title="SB-243213">SB-243213</a></li>
<li><a href="SDZ_SER-082" title="SDZ SER-082">SDZ SER-082</a></li>
<li><a href="Tedatioxetine" title="Tedatioxetine">Tedatioxetine</a></li>
<li><a href="Tetracyclic_antidepressant" title="Tetracyclic antidepressant">Tetracyclic antidepressants</a> (e.g., <a href="Amoxapine" title="Amoxapine">amoxapine</a>, <a href="Aptazapine" title="Aptazapine">aptazapine</a>, <a href="Esmirtazapine" title="Esmirtazapine">esmirtazapine</a>, <a href="Maprotiline" title="Maprotiline">maprotiline</a>, <a href="Mianserin" title="Mianserin">mianserin</a>, <a href="Mirtazapine" title="Mirtazapine">mirtazapine</a>)</li>
<li><a href="TIK-301" title="TIK-301">TIK-301</a></li>
<li><a href="Tramadol" title="Tramadol">Tramadol</a></li>
<li><a href="Trazodone" title="Trazodone">Trazodone</a></li>
<li><a href="Tricyclic_antidepressant" title="Tricyclic antidepressant">Tricyclic antidepressants</a> (e.g., <a href="Amitriptyline" title="Amitriptyline">amitriptyline</a>, <a href="Nortriptyline" title="Nortriptyline">nortriptyline</a>)</li>
<li><a href="Typical_antipsychotic" title="Typical antipsychotic">Typical antipsychotics</a> (e.g., <a href="Chlorpromazine" title="Chlorpromazine">chlorpromazine</a>, <a href="Loxapine" title="Loxapine">loxapine</a>, <a href="Pimozide" title="Pimozide">pimozide</a>, <a href="Pipamperone" title="Pipamperone">pipamperone</a>, <a href="Thioridazine" title="Thioridazine">thioridazine</a>)</li>
<li><a href="Xylamidine" title="Xylamidine">Xylamidine</a></li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Unknown/unsorted:</i> <a href="Efavirenz" title="Efavirenz">Efavirenz</a></li>
<li><a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="Ergometrine" class="mw-redirect" title="Ergometrine">ergometrine (ergonovine)</a>, <a href="Methylergometrine" title="Methylergometrine">methylergometrine (methylergonovine)</a>)</li></ul>
</div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="5-HT3_receptor" title="5-HT3 receptor">5-HT<sub>3</sub></a><sub>–<a href="5-HT7_receptor" title="5-HT7 receptor">7</a></sub></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="5-HT3_receptor" title="5-HT3 receptor">5-HT<sub>3</sub></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Agonists:</i> <a href="Alcohol_(chemistry)" title="Alcohol (chemistry)">Alcohols</a> (e.g., <a href="N-Butanol" class="mw-redirect" title="N-Butanol">butanol</a>, <a href="Alcohol_(drug)" title="Alcohol (drug)">ethanol (alcohol)</a>, <a href="2%2C2%2C2-Trichloroethanol" title="2,2,2-Trichloroethanol">trichloroethanol</a>)</li>
<li><a href="Chlorophenylbiguanide" title="Chlorophenylbiguanide">m-CPBG</a></li>
<li><a href="Phenylbiguanide" title="Phenylbiguanide">Phenylbiguanide</a></li>
<li><a href="Piperazine" title="Piperazine">Piperazines</a> (e.g., <a href="Benzylpiperazine" title="Benzylpiperazine">BZP</a>, <a href="Meta-Chlorophenylpiperazine" title="Meta-Chlorophenylpiperazine">mCPP</a>, <a href="Quipazine" title="Quipazine">quipazine</a>)</li>
<li><a href="RS-56812" title="RS-56812">RS-56812</a></li>
<li><a href="Serotonin" title="Serotonin">Serotonin (5-HT)</a></li>
<li><a href="SR-57227" title="SR-57227">SR-57227</a></li>
<li>SR-57227A</li>
<li><a href="Substituted_tryptamine" title="Substituted tryptamine">Tryptamines</a> (e.g., <a href="2-Methyl-5-hydroxytryptamine" title="2-Methyl-5-hydroxytryptamine">2-Me-5-HT</a>, <a href="5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a>, <a href="Bufotenidine" title="Bufotenidine">bufotenidine (5-HTQ)</a>)</li>
<li><a href="Inhalational_anaesthetic" class="mw-redirect" title="Inhalational anaesthetic">Volatiles/gases</a> (e.g., <a href="Halothane" title="Halothane">halothane</a>, <a href="Isoflurane" title="Isoflurane">isoflurane</a>, <a href="Toluene" title="Toluene">toluene</a>, <a href="1%2C1%2C1-Trichloroethane" title="1,1,1-Trichloroethane">trichloroethane</a>)</li>
<li><a href="YM-31636" title="YM-31636">YM-31636</a></li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Positive allosteric modulators:</i> 5-Aminoindole</li>
<li>5-Chloroindole</li>
<li>5-Hydroxyindole</li>
<li><a href="Catechol" title="Catechol">Catechol</a></li>
<li><a href="Chloroform" title="Chloroform">Chloroform</a></li>
<li><a href="Chlorophenylbiguanide" title="Chlorophenylbiguanide"><i>meta</i>-Chlorophenylbiguanide (mCPBG)</a></li>
<li><a href="Colchicine" title="Colchicine">Colchicine</a></li>
<li><a href="Ethanol" title="Ethanol">Ethanol</a> (<a href="Alcohol_(drug)" title="Alcohol (drug)">alcohol</a>)</li>
<li><a href="Halothane" title="Halothane">Halothane</a></li>
<li><a href="Indole" title="Indole">Indole</a></li>
<li><a href="Isoflurane" title="Isoflurane">Isoflurane</a></li>
<li>TMPPAA</li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Antagonists:</i> <a href="Alosetron" title="Alosetron">Alosetron</a></li>
<li><a href="Anpirtoline" title="Anpirtoline">Anpirtoline</a></li>
<li><a href="Arazasetron" class="mw-redirect" title="Arazasetron">Arazasetron</a></li>
<li><a href="AS-8112" title="AS-8112">AS-8112</a></li>
<li><a href="Atypical_antipsychotic" title="Atypical antipsychotic">Atypical antipsychotics</a> (e.g., <a href="Clozapine" title="Clozapine">clozapine</a>, <a href="Olanzapine" title="Olanzapine">olanzapine</a>, <a href="Quetiapine" title="Quetiapine">quetiapine</a>)</li>
<li><a href="Azasetron" title="Azasetron">Azasetron</a></li>
<li><a href="Batanopride" title="Batanopride">Batanopride</a></li>
<li><a href="Bemesetron" title="Bemesetron">Bemesetron (MDL-72222)</a></li>
<li><a href="Cilansetron" title="Cilansetron">Cilansetron</a></li>
<li><a href="CSP-2503" title="CSP-2503">CSP-2503</a></li>
<li><a href="Dazopride" title="Dazopride">Dazopride</a></li>
<li><a href="Dolasetron" title="Dolasetron">Dolasetron</a></li>
<li><a href="Galanolactone" title="Galanolactone">Galanolactone</a></li>
<li><a href="Granisetron" title="Granisetron">Granisetron</a></li>
<li><a href="Lerisetron" title="Lerisetron">Lerisetron</a></li>
<li><a href="Memantine" title="Memantine">Memantine</a></li>
<li><a href="Ondansetron" title="Ondansetron">Ondansetron</a></li>
<li><a href="Palonosetron" title="Palonosetron">Palonosetron</a></li>
<li><a href="Ramosetron" title="Ramosetron">Ramosetron</a></li>
<li><a href="Renzapride" title="Renzapride">Renzapride</a></li>
<li><a href="Ricasetron" title="Ricasetron">Ricasetron</a></li>
<li><a href="Tedatioxetine" title="Tedatioxetine">Tedatioxetine</a></li>
<li><a href="Tetracyclic_antidepressant" title="Tetracyclic antidepressant">Tetracyclic antidepressants</a> (e.g., <a href="Amoxapine" title="Amoxapine">amoxapine</a>, <a href="Mianserin" title="Mianserin">mianserin</a>, <a href="Mirtazapine" title="Mirtazapine">mirtazapine</a>)</li>
<li><a href="Thujone" title="Thujone">Thujone</a></li>
<li><a href="Tropanserin" title="Tropanserin">Tropanserin</a></li>
<li><a href="Tropisetron" title="Tropisetron">Tropisetron</a></li>
<li><a href="Typical_antipsychotic" title="Typical antipsychotic">Typical antipsychotics</a> (e.g., <a href="Loxapine" title="Loxapine">loxapine</a>)</li>
<li><a href="Inhalational_anaesthetic" class="mw-redirect" title="Inhalational anaesthetic">Volatiles/gases</a> (e.g., <a href="Nitrous_oxide" title="Nitrous oxide">nitrous oxide</a>, <a href="Sevoflurane" title="Sevoflurane">sevoflurane</a>, <a href="Xenon" title="Xenon">xenon</a>)</li>
<li><a href="Vortioxetine" title="Vortioxetine">Vortioxetine</a></li>
<li><a href="Zacopride" title="Zacopride">Zacopride</a></li>
<li><a href="Zatosetron" title="Zatosetron">Zatosetron</a></li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Negative allosteric modulators:</i> <a href="Bupropion" title="Bupropion">Bupropion</a></li>
<li><a href="Colchicine" title="Colchicine">Colchicine</a></li>
<li><a href="Hydroxybupropion" title="Hydroxybupropion">Hydroxybupropion</a></li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Unknown/unsorted:</i> LY-53857</li>
<li><a href="Piperazine" title="Piperazine">Piperazines</a> (e.g., <a href="Naphthylpiperazine" title="Naphthylpiperazine">naphthylpiperazine</a>)</li></ul>
</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="5-HT4_receptor" title="5-HT4 receptor">5-HT<sub>4</sub></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Agonists:</i> <a href="5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a></li>
<li><a href="BIMU8" title="BIMU8">BIMU8</a></li>
<li><a href="Capeserod" title="Capeserod">Capeserod</a></li>
<li><a href="Cinitapride" title="Cinitapride">Cinitapride</a></li>
<li><a href="Cisapride" title="Cisapride">Cisapride</a></li>
<li><a href="CJ-033466" title="CJ-033466">CJ-033466</a></li>
<li><a href="Dazopride" title="Dazopride">Dazopride</a></li>
<li><a href="Metoclopramide" title="Metoclopramide">Metoclopramide</a></li>
<li>Minesapride</li>
<li><a href="Mosapride" title="Mosapride">Mosapride</a></li>
<li><a href="Prucalopride" title="Prucalopride">Prucalopride</a></li>
<li><a href="PRX-03140" title="PRX-03140">PRX-03140</a></li>
<li><a href="Renzapride" title="Renzapride">Renzapride</a></li>
<li><a href="RS-67333" title="RS-67333">RS-67333</a></li>
<li>RS-67506</li>
<li><a href="Serotonin" title="Serotonin">Serotonin (5-HT)</a></li>
<li><a href="Tegaserod" title="Tegaserod">Tegaserod</a></li>
<li>Usmarapride</li>
<li><a href="Velusetrag" title="Velusetrag">Velusetrag</a></li>
<li><a href="Zacopride" title="Zacopride">Zacopride</a></li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Antagonists:</i> <a href="GR-113808" title="GR-113808">GR-113808</a></li>
<li>GR-125487</li>
<li><a href="Lysine" title="Lysine">L-Lysine</a></li>
<li><a href="Piboserod" title="Piboserod">Piboserod</a></li>
<li>RS-39604</li>
<li>RS-67532</li>
<li>SB-203186</li>
<li><a href="SB-204070" title="SB-204070">SB-204070</a></li></ul>
</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="5-HT5A_receptor" title="5-HT5A receptor">5-HT<sub>5A</sub></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Agonists:</i> <a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="2-Bromo-LSD" title="2-Bromo-LSD">2-Br-LSD (BOL-148)</a>, <a href="Ergotamine" title="Ergotamine">ergotamine</a>, <a href="LSD" title="LSD">LSD</a>)</li>
<li><a href="Serotonin" title="Serotonin">Serotonin (5-HT)</a></li>
<li><a href="Substituted_tryptamine" title="Substituted tryptamine">Tryptamines</a> (e.g., <a href="5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a>)</li>
<li><a href="UCSF648" title="UCSF648">UCSF648</a></li>
<li><a href="Valerenic_acid" title="Valerenic acid">Valerenic acid</a></li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Antagonists:</i> <a href="Asenapine" title="Asenapine">Asenapine</a></li>
<li><a href="Latrepirdine" title="Latrepirdine">Latrepirdine (dimebolin)</a></li>
<li><a href="Metitepine" title="Metitepine">Metitepine (methiothepin)</a></li>
<li><a href="Ritanserin" title="Ritanserin">Ritanserin</a></li>
<li><a href="SB-699551" title="SB-699551">SB-699551</a></li></ul>
<ul><li><i>Unknown/unsorted:</i> <a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="Metergoline" title="Metergoline">metergoline</a>, <a href="Methysergide" title="Methysergide">methysergide</a>)</li>
<li><a href="Piperazine" title="Piperazine">Piperazines</a> (e.g., <a href="Naphthylpiperazine" title="Naphthylpiperazine">naphthylpiperazine</a>)</li></ul>
</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="5-HT6_receptor" title="5-HT6 receptor">5-HT<sub>6</sub></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Agonists:</i> <a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="Dihydroergocryptine" title="Dihydroergocryptine">dihydroergocryptine</a>, <a href="Dihydroergotamine" title="Dihydroergotamine">dihydroergotamine</a>, <a href="Ergotamine" title="Ergotamine">ergotamine</a>, <a href="Lisuride" title="Lisuride">lisuride</a>, <a href="LSD" title="LSD">LSD</a>, <a href="Mesulergine" title="Mesulergine">mesulergine</a>, <a href="Metergoline" title="Metergoline">metergoline</a>, <a href="Methysergide" title="Methysergide">methysergide</a>)</li>
<li><a href="Hypidone" title="Hypidone">Hypidone</a></li>
<li><a href="Serotonin" title="Serotonin">Serotonin (5-HT)</a></li>
<li><a href="Substituted_tryptamine" title="Substituted tryptamine">Tryptamines</a> (e.g., <a href="2-Methyl-5-hydroxytryptamine" title="2-Methyl-5-hydroxytryptamine">2-Me-5-HT</a>, <a href="5-Benzyloxytryptamine" title="5-Benzyloxytryptamine">5-BT</a>, <a href="5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a>, <a href="5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a>, <a href="Bufotenin" title="Bufotenin">Bufotenin</a>, <a href="E-6801" title="E-6801">E-6801</a>, <a href="E-6837" title="E-6837">E-6837</a>, <a href="EMD-386088" title="EMD-386088">EMD-386088</a>, <a href="EMDT" title="EMDT">EMDT</a>, LY-586713, <a href="N-Methyl-5-HT" class="mw-redirect" title="N-Methyl-5-HT">N-Me-5-HT</a>, <a href="ST-1936" title="ST-1936">ST-1936</a>, <a href="Tryptamine" title="Tryptamine">tryptamine</a>)</li>
<li><a href="WAY-181187" title="WAY-181187">WAY-181187</a></li>
<li><a href="WAY-208466" title="WAY-208466">WAY-208466</a></li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Antagonists:</i> <a href="ABT-354" title="ABT-354">ABT-354</a></li>
<li><a href="Atypical_antipsychotic" title="Atypical antipsychotic">Atypical antipsychotics</a> (e.g., <a href="Aripiprazole" title="Aripiprazole">aripiprazole</a>, <a href="Asenapine" title="Asenapine">asenapine</a>, <a href="Clorotepine" title="Clorotepine">clorotepine</a>, <a href="Clozapine" title="Clozapine">clozapine</a>, <a href="Fluperlapine" title="Fluperlapine">fluperlapine</a>, <a href="Iloperidone" title="Iloperidone">iloperidone</a>, <a href="Olanzapine" title="Olanzapine">olanzapine</a>, <a href="Tiospirone" title="Tiospirone">tiospirone</a>)</li>
<li><a href="AVN-101" class="mw-redirect" title="AVN-101">AVN-101</a></li>
<li><a href="AVN-211" title="AVN-211">AVN-211</a></li>
<li><a href="AVN-322" title="AVN-322">AVN-322</a></li>
<li><a href="AVN-397" title="AVN-397">AVN-397</a></li>
<li>BGC20-760</li>
<li>BVT-5182</li>
<li>BVT-74316</li>
<li><a href="Cerlapirdine" title="Cerlapirdine">Cerlapirdine</a></li>
<li><a href="EGIS-12233" title="EGIS-12233">EGIS-12233</a></li>
<li>GW-742457</li>
<li><a href="Idalopirdine" title="Idalopirdine">Idalopirdine</a></li>
<li><a href="Ketanserin" title="Ketanserin">Ketanserin</a></li>
<li>Landipirdine</li>
<li><a href="Latrepirdine" title="Latrepirdine">Latrepirdine (dimebolin)</a></li>
<li><a href="Masupirdine" title="Masupirdine">Masupirdine</a></li>
<li><a href="Metitepine" title="Metitepine">Metitepine (methiothepin)</a></li>
<li><a href="MS-245" title="MS-245">MS-245</a></li>
<li><a href="PRX-07034" title="PRX-07034">PRX-07034</a></li>
<li><a href="Ritanserin" title="Ritanserin">Ritanserin</a></li>
<li><a href="Ro_04-6790" title="Ro 04-6790">Ro 04-6790</a></li>
<li>Ro 63-0563</li>
<li><a href="SB-258585" title="SB-258585">SB-258585</a></li>
<li><a href="SB-271046" title="SB-271046">SB-271046</a></li>
<li><a href="SB-357134" title="SB-357134">SB-357134</a></li>
<li><a href="SB-399885" title="SB-399885">SB-399885</a></li>
<li><a href="Intepirdine" title="Intepirdine">SB-742457</a></li>
<li><a href="Tetracyclic_antidepressant" title="Tetracyclic antidepressant">Tetracyclic antidepressants</a> (e.g., <a href="Amoxapine" title="Amoxapine">amoxapine</a>, <a href="Mianserin" title="Mianserin">mianserin</a>)</li>
<li><a href="Tricyclic_antidepressant" title="Tricyclic antidepressant">Tricyclic antidepressants</a> (e.g., <a href="Amitriptyline" title="Amitriptyline">amitriptyline</a>, <a href="Clomipramine" title="Clomipramine">clomipramine</a>, <a href="Doxepin" title="Doxepin">doxepin</a>, <a href="Nortriptyline" title="Nortriptyline">nortriptyline</a>)</li>
<li><a href="Typical_antipsychotic" title="Typical antipsychotic">Typical antipsychotics</a> (e.g., <a href="Chlorpromazine" title="Chlorpromazine">chlorpromazine</a>, <a href="Loxapine" title="Loxapine">loxapine</a>)</li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Unknown/unsorted:</i> <a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="2-Bromo-LSD" title="2-Bromo-LSD">2-Br-LSD (BOL-148)</a>, <a href="Bromocriptine" title="Bromocriptine">bromocriptine</a>, <a href="Lergotrile" title="Lergotrile">lergotrile</a>, <a href="Pergolide" title="Pergolide">pergolide</a>)</li>
<li><a href="Piperazine" title="Piperazine">Piperazines</a> (e.g., <a href="Naphthylpiperazine" title="Naphthylpiperazine">naphthylpiperazine</a>)</li></ul>
</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="5-HT7_receptor" title="5-HT7 receptor">5-HT<sub>7</sub></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Agonists:</i> <a href="8-OH-DPAT" title="8-OH-DPAT">8-OH-DPAT</a></li>
<li><a href="AS-19_(drug)" title="AS-19 (drug)">AS-19</a></li>
<li><a href="Bifeprunox" title="Bifeprunox">Bifeprunox</a></li>
<li><a href="E-55888" title="E-55888">E-55888</a></li>
<li><a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="LSD" title="LSD">LSD</a>)</li>
<li><a href="LP-12" title="LP-12">LP-12</a></li>
<li><a href="LP-44" title="LP-44">LP-44</a></li>
<li><a href="LP-211" title="LP-211">LP-211</a></li>
<li><a href="RU-24969" title="RU-24969">RU-24969</a></li>
<li><a href="Sarizotan" title="Sarizotan">Sarizotan</a></li>
<li><a href="Serotonin" title="Serotonin">Serotonin (5-HT)</a></li>
<li><a href="Triptan" title="Triptan">Triptans</a> (e.g., <a href="Frovatriptan" title="Frovatriptan">frovatriptan</a>)</li>
<li><a href="Substituted_tryptamine" title="Substituted tryptamine">Tryptamines</a> (e.g., <a href="5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a>, <a href="5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a>, <a href="Bufotenin" title="Bufotenin">bufotenin</a>, <a href="N-Methylserotonin" title="N-Methylserotonin">N-Me-5-HT</a>)</li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Antagonists:</i> <a href="Atypical_antipsychotic" title="Atypical antipsychotic">Atypical antipsychotics</a> (e.g., <a href="Amisulpride" title="Amisulpride">amisulpride</a>, <a href="Aripiprazole" title="Aripiprazole">aripiprazole</a>, <a href="Asenapine" title="Asenapine">asenapine</a>, <a href="Brexpiprazole" title="Brexpiprazole">brexpiprazole</a>, <a href="Clorotepine" title="Clorotepine">clorotepine</a>, <a href="Clozapine" title="Clozapine">clozapine</a>, <a href="Fluperlapine" title="Fluperlapine">fluperlapine</a>, <a href="Olanzapine" title="Olanzapine">olanzapine</a>, <a href="Risperidone" title="Risperidone">risperidone</a>, <a href="Sertindole" title="Sertindole">sertindole</a>, <a href="Tiospirone" title="Tiospirone">tiospirone</a>, <a href="Ziprasidone" title="Ziprasidone">ziprasidone</a>, <a href="Zotepine" title="Zotepine">zotepine</a>)</li>
<li><a href="Butaclamol" title="Butaclamol">Butaclamol</a></li>
<li><a href="DR-4485" title="DR-4485">DR-4485</a></li>
<li><a href="EGIS-12233" title="EGIS-12233">EGIS-12233</a></li>
<li><a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="2-Bromo-LSD" title="2-Bromo-LSD">2-Br-LSD (BOL-148)</a>, <a href="Amesergide" title="Amesergide">amesergide</a>, <a href="Bromocriptine" title="Bromocriptine">bromocriptine</a>, <a href="Cabergoline" title="Cabergoline">cabergoline</a>, <a href="Dihydroergotamine" title="Dihydroergotamine">dihydroergotamine</a>, <a href="Ergotamine" title="Ergotamine">ergotamine</a>, LY-53857, <a href="LY-215840" title="LY-215840">LY-215840</a>, <a href="Mesulergine" title="Mesulergine">mesulergine</a>, <a href="Metergoline" title="Metergoline">metergoline</a>, <a href="Methysergide" title="Methysergide">methysergide</a>, <a href="Sergolexole" title="Sergolexole">sergolexole</a>)</li>
<li><a href="JNJ-18038683" title="JNJ-18038683">JNJ-18038683</a></li>
<li><a href="Ketanserin" title="Ketanserin">Ketanserin</a></li>
<li><a href="LY-215840" title="LY-215840">LY-215840</a></li>
<li><a href="Metitepine" title="Metitepine">Metitepine (methiothepin)</a></li>
<li><a href="Ritanserin" title="Ritanserin">Ritanserin</a></li>
<li><a href="SB-258719" title="SB-258719">SB-258719</a></li>
<li>SB-258741</li>
<li><a href="SB-269970" title="SB-269970">SB-269970</a></li>
<li>SB-656104</li>
<li>SB-656104A</li>
<li>SB-691673</li>
<li>SLV-313</li>
<li>SLV-314</li>
<li><a href="Spiperone" title="Spiperone">Spiperone</a></li>
<li>SSR-181507</li>
<li><a href="Tetracyclic_antidepressant" title="Tetracyclic antidepressant">Tetracyclic antidepressants</a> (e.g., <a href="Amoxapine" title="Amoxapine">amoxapine</a>, <a href="Maprotiline" title="Maprotiline">maprotiline</a>, <a href="Mianserin" title="Mianserin">mianserin</a>, <a href="Mirtazapine" title="Mirtazapine">mirtazapine</a>)</li>
<li><a href="Tricyclic_antidepressant" title="Tricyclic antidepressant">Tricyclic antidepressants</a> (e.g., <a href="Amitriptyline" title="Amitriptyline">amitriptyline</a>, <a href="Clomipramine" title="Clomipramine">clomipramine</a>, <a href="Imipramine" title="Imipramine">imipramine</a>)</li>
<li><a href="Typical_antipsychotic" title="Typical antipsychotic">Typical antipsychotics</a> (e.g., <a href="Acetophenazine" title="Acetophenazine">acetophenazine</a>, <a href="Chlorpromazine" title="Chlorpromazine">chlorpromazine</a>, <a href="Chlorprothixene" title="Chlorprothixene">chlorprothixene</a>, <a href="Fluphenazine" title="Fluphenazine">fluphenazine</a>, <a href="Loxapine" title="Loxapine">loxapine</a>, <a href="Pimozide" title="Pimozide">pimozide</a>)</li>
<li><a href="Vortioxetine" title="Vortioxetine">Vortioxetine</a></li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Negative allosteric modulators:</i> <a href="Oleamide" title="Oleamide">Oleamide</a></li></ul>
</div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>Unknown/unsorted:</i> <a href="Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="Lisuride" title="Lisuride">lisuride</a>, <a href="Pergolide" title="Pergolide">pergolide</a>)</li>
<li><a href="Piperazine" title="Piperazine">Piperazines</a> (e.g., <a href="Naphthylpiperazine" title="Naphthylpiperazine">naphthylpiperazine</a>)</li></ul>
</div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div>
<ul><li><i><b>See also:</b> Receptor/signaling modulators</i></li>
<li><i>Adrenergics</i></li>
<li><i>Dopaminergics</i></li>
<li><i>Melatonergics</i></li>
<li><i>Monoamine reuptake inhibitors and releasing agents</i></li>
<li><i>Monoamine metabolism modulators</i></li>
<li><i>Monoamine neurotoxins</i></li></ul>
</div></td></tr></tbody></table></div>
<div class="navbox-styles"></div><div role="navigation" class="navbox" aria-labelledby="Tryptamines596" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Tryptamines596" style="font-size:114%;margin:0 4em"><a href="Substituted_tryptamine" title="Substituted tryptamine">Tryptamines</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="Substituted_tryptamine" title="Substituted tryptamine">Tryptamines</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="1-Methyltryptamine" title="1-Methyltryptamine">1-Methyl-T</a></li>
<li><a href="2-HO-NMT" title="2-HO-NMT">2-HO-NMT</a></li>
<li><a href="2-Methyl-DET" class="mw-redirect" title="2-Methyl-DET">2-Methyl-DET</a></li>
<li><a href="2%2CN%2CN-TMT" title="2,N,N-TMT">2,<i>N</i>,<i>N</i>-TMT (2-Me-DMT)</a></li>
<li>3-IAAR</li>
<li><a href="4-Fluoro-DMT" title="4-Fluoro-DMT">4-Fluoro-DMT</a></li>
<li>4-Fluoro-T</li>
<li><a href="5-Bromo-DMT" title="5-Bromo-DMT">5-Bromo-DMT</a></li>
<li>5-Bromo-T</li>
<li><a href="5-Chloro-DMT" title="5-Chloro-DMT">5-Chloro-DMT</a></li>
<li>5-Chloro-T</li>
<li><a href="5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a></li>
<li><a href="5-Ethyl-DMT" title="5-Ethyl-DMT">5-Ethyl-DMT</a></li>
<li><a href="5-Fluoro-DET" title="5-Fluoro-DET">5-Fluoro-DET</a></li>
<li><a href="5-Fluoro-DMT" title="5-Fluoro-DMT">5-Fluoro-DMT</a></li>
<li><a href="5-Fluoro-EPT" title="5-Fluoro-EPT">5-Fluoro-EPT</a></li>
<li><a href="5-Fluorotryptamine" title="5-Fluorotryptamine">5-Fluoro-T</a></li>
<li><a href="5-Me-MiPT" title="5-Me-MiPT">5-Me-MiPT</a></li>
<li><a href="5-MeS-DMT" title="5-MeS-DMT">5-MeS-DMT</a></li>
<li><a href="5%2CN%2CN-TMT" title="5,N,N-TMT">5-Methyl-DMT</a></li>
<li><a href="5-Methyltryptamine" title="5-Methyltryptamine">5-Methyl-T</a></li>
<li><a href="6-Fluoro-DET" title="6-Fluoro-DET">6-Fluoro-DET</a></li>
<li><a href="6-Fluoro-DMT" title="6-Fluoro-DMT">6-Fluoro-DMT</a></li>
<li><a href="6-Fluorotryptamine" title="6-Fluorotryptamine">6-Fluoro-T</a></li>
<li><a href="6-Hydroxy-DMT" title="6-Hydroxy-DMT">6-HO-DMT</a></li>
<li><a href="6-Hydroxytryptamine" title="6-Hydroxytryptamine">6-HO-T (6-HT)</a></li>
<li><a href="6-MeO-DMT" title="6-MeO-DMT">6-MeO-DMT</a></li>
<li><a href="6-Methoxytryptamine" title="6-Methoxytryptamine">6-MeO-T</a></li>
<li>6-Methyl-T</li>
<li><a href="6%2C7-Dihydroxytryptamine" title="6,7-Dihydroxytryptamine">6,7-DHT</a></li>
<li><a href="7-Chlorotryptamine" title="7-Chlorotryptamine">7-Chloro-T</a></li>
<li>7-HO-T (7-HT)</li>
<li><a href="7-MeO-DMT" title="7-MeO-DMT">7-MeO-DMT</a></li>
<li>7-MeO-T</li>
<li><a href="7%2CN%2CN-TMT" title="7,N,N-TMT">7-Methyl-DMT</a></li>
<li>7-Methyl-T</li>
<li><a href="Acetryptine" title="Acetryptine">Acetryptine (5-AT)</a></li>
<li><a href="Almotriptan" title="Almotriptan">Almotriptan</a></li>
<li><a href="Benzotript" title="Benzotript">Benzotript (4-CB-Trp)</a></li>
<li>BGE</li>
<li><a href="Bretisilocin" title="Bretisilocin">Bretisilocin (5-fluoro-MET; GM-2505)</a></li>
<li><a href="Convolutindole_A" title="Convolutindole A">Convolutindole A (2,4,6-TBr,1,7-DiMeO-DMT)</a></li>
<li><a href="DALT" title="DALT">DALT</a></li>
<li>DAT</li>
<li><a href="Dibutyltryptamine" title="Dibutyltryptamine">DBT</a></li>
<li><a href="Desformylflustrabromine" title="Desformylflustrabromine">Desformylflustrabromine</a></li>
<li><a href="Diethyltryptamine" title="Diethyltryptamine">DET (T-9)</a></li>
<li><a href="Dihexyltryptamine" title="Dihexyltryptamine">DHT</a></li>
<li><a href="Diisopropyltryptamine" class="mw-redirect" title="Diisopropyltryptamine">DiPT</a></li>
<li><a href="Dimethyltryptamine" title="Dimethyltryptamine">DMT</a></li>
<li><a href="Dipropyltryptamine" title="Dipropyltryptamine">DPT</a></li>
<li><a href="E-6801" title="E-6801">E-6801</a></li>
<li><a href="E-6837" title="E-6837">E-6837</a></li>
<li><a href="Ethylisopropyltryptamine" title="Ethylisopropyltryptamine">EiPT</a></li>
<li><a href="Ethylpropyltryptamine" title="Ethylpropyltryptamine">EPT</a></li>
<li><a href="FGIN-127" title="FGIN-127">FGIN-127</a></li>
<li><a href="FGIN-143" title="FGIN-143">FGIN-143</a></li>
<li><a href="Idalopirdine" title="Idalopirdine">Idalopirdine</a></li>
<li>iPALT (ALiPT)</li>
<li><a href="Lespedamine" title="Lespedamine">Lespedamine (1-MeO-DMT)</a></li>
<li><a href="L-694247" title="L-694247">L-694247</a></li>
<li><a href="Methylbutyltryptamine" title="Methylbutyltryptamine">MBT</a></li>
<li><a href="Methylethyltryptamine" title="Methylethyltryptamine">MET</a></li>
<li><a href="Methylisopropyltryptamine" class="mw-redirect" title="Methylisopropyltryptamine">MiPT</a></li>
<li><a href="4-Acetoxy-MiPT" class="mw-redirect" title="4-Acetoxy-MiPT">MPT</a></li>
<li><a href="Methylbutyltryptamine#MSBT" title="Methylbutyltryptamine">MSBT</a></li>
<li><a href="N-Benzyltryptamine" title="N-Benzyltryptamine"><i>N</i>-Benzyltryptamine (T-NB, NB-T)</a></li>
<li><a href="N-DEAOP-NET" class="mw-redirect" title="N-DEAOP-NET"><i>N</i>-DEAOP-NET</a></li>
<li><a href="N-DEAOP-NMT" title="N-DEAOP-NMT"><i>N</i>-DEAOP-NMT</a></li>
<li><a href="NBoc-DMT" title="NBoc-DMT">NBoc-DMT</a></li>
<li><a href="N-Ethyltryptamine" title="N-Ethyltryptamine">NET/NETP</a></li>
<li><a href="N-Isopropyltryptamine" title="N-Isopropyltryptamine">NiPT</a></li>
<li><a href="N-Methyltryptamine" title="N-Methyltryptamine">NMT</a></li>
<li>NSBT</li>
<li><a href="N-t-Butyltryptamine" title="N-t-Butyltryptamine">NTBT</a></li>
<li>PALT</li>
<li><a href="Propylisopropyltryptamine" title="Propylisopropyltryptamine">PiPT</a></li>
<li><a href="Rizatriptan" title="Rizatriptan">Rizatriptan</a></li>
<li><a href="ST-1936" title="ST-1936">ST-1936 (2-Me-5-Cl-DMT)</a></li>
<li><a href="Sumatriptan" title="Sumatriptan">Sumatriptan</a></li>
<li><a href="TCS-1205" title="TCS-1205">TCS-1205</a></li>
<li><a href="Tryptamine" title="Tryptamine">Tryptamine (T; indolylethylamine)</a></li>
<li><a href="Tryptophan" title="Tryptophan">Tryptophan (Trp)</a></li>
<li><a href="WAY-181187" title="WAY-181187">WAY-181187</a></li>
<li><a href="Yuremamine" title="Yuremamine">Yuremamine</a></li>
<li>Z2876442907</li>
</ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="Substituted_4-hydroxytryptamine" class="mw-redirect" title="Substituted 4-hydroxytryptamine">4-Hydroxytryptamines</a><br>and <a href="Ester" title="Ester">esters</a>/<a href="Ether" title="Ether">ethers</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="1-Methylpsilocin" title="1-Methylpsilocin">1-Methylpsilocin (CMY-16)</a></li>
<li><a href="4-AcO-DALT" title="4-AcO-DALT">4-AcO-DALT</a></li>
<li><a href="4-Acetoxy-DET" class="mw-redirect" title="4-Acetoxy-DET">4-AcO-DET (ethacetin, ethylacybin)</a></li>
<li><a href="4-Acetoxy-DiPT" title="4-Acetoxy-DiPT">4-AcO-DiPT (ipracetin)</a></li>
<li><a href="4-AcO-DMT" title="4-AcO-DMT">4-AcO-DMT (psilacetin; <i>O</i>-acetylpsilocin)</a></li>
<li><a href="4-AcO-DPT" title="4-AcO-DPT">4-AcO-DPT (depracetin)</a></li>
<li>4-AcO-EPT</li>
<li><a href="4-AcO-MALT" title="4-AcO-MALT">4-AcO-MALT</a></li>
<li><a href="4-Acetoxy-MET" class="mw-redirect" title="4-Acetoxy-MET">4-AcO-MET (metacetin)</a></li>
<li><a href="4-Acetoxy-MiPT" class="mw-redirect" title="4-Acetoxy-MiPT">4-AcO-MiPT (mipracetin)</a></li>
<li>4-AcO-NMT</li>
<li>4-AcO-TMT</li>
<li><a href="4-Hydroxy-5-methoxytryptamine" title="4-Hydroxy-5-methoxytryptamine">4-HO-5-MeO-T</a></li>
<li><a href="4-HO-DALT" title="4-HO-DALT">4-HO-DALT (dalocin)</a></li>
<li><a href="4-HO-DBT" title="4-HO-DBT">4-HO-DBT</a></li>
<li><a href="4-HO-DET" title="4-HO-DET">4-HO-DET (ethocin; CZ-74)</a></li>
<li><a href="4-HO-DPT" title="4-HO-DPT">4-HO-DPT (deprocin)</a></li>
<li><a href="4-HO-DSBT" title="4-HO-DSBT">4-HO-DSBT</a></li>
<li><a href="4-HO-EiBT" title="4-HO-EiBT">4-HO-EiBT (eibucin)</a></li>
<li><a href="4-HO-EPT" title="4-HO-EPT">4-HO-EPT</a></li>
<li><a href="4-HO-MALT" title="4-HO-MALT">4-HO-MALT</a></li>
<li><a href="4-HO-MET" title="4-HO-MET">4-HO-MET (metocin)</a></li>
<li><a href="4-HO-McPT" title="4-HO-McPT">4-HO-McPT</a></li>
<li><a href="4-HO-McPeT" title="4-HO-McPeT">4-HO-McPeT</a></li>
<li><a href="4-HO-MiPT" title="4-HO-MiPT">4-HO-MiPT (miprocin)</a></li>
<li><a href="4-HO-MPT" title="4-HO-MPT">4-HO-MPT (meprocin)</a></li>
<li>4-HO-MsBT</li>
<li><a href="4-HO-NALT" title="4-HO-NALT">4-HO-NALT</a></li>
<li>4-HO-NiPT</li>
<li><a href="4-HO-PiPT" title="4-HO-PiPT">4-HO-PiPT (piprocin)</a></li>
<li><a href="4-HO-TMT" title="4-HO-TMT">4-HO-TMT</a></li>
<li><a href="4-Hydroxytryptamine" title="4-Hydroxytryptamine">4-HT (dinorpsilocin)</a></li>
<li>4-MeO-DiPT</li>
<li><a href="4-MeO-DMT" title="4-MeO-DMT">4-MeO-DMT</a></li>
<li><a href="4-MeO-MiPT" title="4-MeO-MiPT">4-MeO-MiPT</a></li>
<li><a href="4-Methoxytryptamine" title="4-Methoxytryptamine">4-MeO-T</a></li>
<li><a href="4-PrO-DMT" title="4-PrO-DMT">4-PrO-DMT</a></li>
<li><a href="4%2C5-Dihydroxytryptamine" title="4,5-Dihydroxytryptamine">4,5-DHT</a></li>
<li><a href="4%2C5-MDO-DMT" title="4,5-MDO-DMT">4,5-MDO-DMT</a></li>
<li><a href="4%2C5-MDO-DiPT" title="4,5-MDO-DiPT">4,5-MDO-DiPT</a></li>
<li><a href="Aeruginascin" title="Aeruginascin">Aeruginascin (4-PO-TMT)</a></li>
<li><a href="Baeocystin" title="Baeocystin">Baeocystin (4-PO-NMT)</a></li>
<li><a href="EB-002" title="EB-002">EB-002 (EB-373)</a></li>
<li><a href="Ethocybin" title="Ethocybin">Ethocybin (4-PO-DET; CEY-19)</a></li>
<li><a href="4-HO-DiPT" title="4-HO-DiPT">Iprocin (4-HO-DiPT)</a></li>
<li><a href="Luvesilocin" title="Luvesilocin">Luvesilocin (4-GO-DiPT; RE-104; FT-104)</a></li>
<li><a href="MSP-1014" title="MSP-1014">MSP-1014</a></li>
<li><a href="Norbaeocystin" title="Norbaeocystin">Norbaeocystin (4-PO-T)</a></li>
<li><a href="Norpsilocin" title="Norpsilocin">Norpsilocin (4-HO-NMT)</a></li>
<li><a href="O-4310" title="O-4310">O-4310 (1-iPrO-6-F-psilocin)</a></li>
<li><a href="Psilocin" title="Psilocin">Psilocin (4-HO-DMT; CX-59)</a></li>
<li><a href="Psilocybin" title="Psilocybin">Psilocybin (4-PO-DMT; CY-39)</a></li>
<li><a href="Psilomethoxin" title="Psilomethoxin">Psilomethoxin (4-HO-5-MeO-DMT)</a></li>
<li><a href="Psilomethoxybin" class="mw-redirect" title="Psilomethoxybin">Psilomethoxybin (4-PO-5-MeO-DMT)</a></li></ul>
<ul><li><a href="RE-109" title="RE-109">RE-109 (4-GO-DMT)</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="Substituted_5-hydroxytryptamine" class="mw-redirect" title="Substituted 5-hydroxytryptamine">5-Hydroxy-</a> and<br><a href="Substituted_5-methoxytryptamine" class="mw-redirect" title="Substituted 5-methoxytryptamine">5-methoxytryptamines</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="2-Methyl-5-hydroxytryptamine" title="2-Methyl-5-hydroxytryptamine">2-Methyl-5-HT</a></li>
<li><a href="4-Hydroxy-5-methoxytryptamine" title="4-Hydroxy-5-methoxytryptamine">4-HO-5-MeO-T</a></li>
<li><a href="4-Fluoro-5-methoxy-DMT" title="4-Fluoro-5-methoxy-DMT">4-F-5-MeO-DMT</a></li>
<li><a href="1-(2-Dimethylaminoethyl)dihydropyrano(3%2C2-e)indole" class="mw-redirect" title="1-(2-Dimethylaminoethyl)dihydropyrano(3,2-e)indole">4,5-DHP-DMT</a></li>
<li><a href="4%2C5-Dihydroxytryptamine" title="4,5-Dihydroxytryptamine">4,5-DHT</a></li>
<li><a href="4%2C5-MDO-DMT" title="4,5-MDO-DMT">4,5-MDO-DMT</a></li>
<li><a href="4%2C5-MDO-DiPT" title="4,5-MDO-DiPT">4,5-MDO-DiPT</a></li>
<li><a href="5-Benzyloxytryptamine" title="5-Benzyloxytryptamine">5-BT</a></li>
<li><a href="5-Ethoxy-DMT" title="5-Ethoxy-DMT">5-Ethoxy-DMT</a></li>
<li><a href="5-HO-DET" title="5-HO-DET">5-HO-DET</a></li>
<li><a href="5-HO-DiPT" title="5-HO-DiPT">5-HO-DiPT</a></li>
<li>5-HO-NiPT</li>
<li><a href="5-HO-DPT" title="5-HO-DPT">5-HO-DPT</a></li>
<li><a href="5-Hydroxytryptophan" title="5-Hydroxytryptophan">5-HTP</a> (<a href="Oxitriptan" title="Oxitriptan">oxitriptan</a>)</li>
<li><a href="5-MeO-2-TMT" title="5-MeO-2-TMT">5-MeO-2-TMT</a></li>
<li>5-MeO-34MPEMT</li>
<li><a href="5-Methoxy-7%2CN%2CN-trimethyltryptamine" title="5-Methoxy-7,N,N-trimethyltryptamine">5-MeO-7,<i>N</i>,<i>N</i>-TMT</a></li>
<li><a href="5-MeO-DALT" title="5-MeO-DALT">5-MeO-DALT</a></li>
<li><a href="5-MeO-DBT" title="5-MeO-DBT">5-MeO-DBT</a></li>
<li><a href="5-MeO-DET" title="5-MeO-DET">5-MeO-DET</a></li>
<li><a href="5-Methoxy-N%2CN-diisopropyltryptamine" class="mw-redirect" title="5-Methoxy-N,N-diisopropyltryptamine">5-MeO-DiPT</a></li>
<li><a href="5-MeO-DMT" title="5-MeO-DMT">5-MeO-DMT (<i>N</i>,<i>N</i>,<i>O</i>-TMS; <i>O</i>-methylbufotenine)</a></li>
<li><a href="5-MeO-DPT" title="5-MeO-DPT">5-MeO-DPT</a></li>
<li><a href="5-MeO-EiPT" title="5-MeO-EiPT">5-MeO-EiPT</a></li>
<li><a href="5-MeO-EPT" title="5-MeO-EPT">5-MeO-EPT</a></li>
<li><a href="5-MeO-MALT" title="5-MeO-MALT">5-MeO-MALT</a></li>
<li><a href="5-MeO-MET" title="5-MeO-MET">5-MeO-MET</a></li>
<li><a href="5-MeO-MiPT" title="5-MeO-MiPT">5-MeO-MiPT</a></li>
<li><a href="5-MeO-NET" title="5-MeO-NET">5-MeO-NET</a></li>
<li><a href="5-MeO-NiPT" title="5-MeO-NiPT">5-MeO-NiPT</a></li>
<li><a href="5-MeO-NMT" title="5-MeO-NMT">5-MeO-NMT (<i>O</i>,<i>N</i>-DMS)</a></li>
<li><a href="5-MeO-PiPT" title="5-MeO-PiPT">5-MeO-PiPT</a></li>
<li><a href="5-MeO-NBpBrT" title="5-MeO-NBpBrT">5-MeO-NBpBrT</a></li>
<li><a href="5-Methoxytryptamine" title="5-Methoxytryptamine">5-MeO-T (5-MT; mexamine; <i>O</i>-methylserotonin)</a></li>
<li><a href="5-MeO-T-NBOMe" title="5-MeO-T-NBOMe">5-MeO-T-NBOMe</a></li>
<li>5-MT-NB3OMe</li>
<li><a href="5-(Nonyloxy)tryptamine" title="5-(Nonyloxy)tryptamine">5-NOT</a></li>
<li><a href="5%2C6-Dihydroxytryptamine" title="5,6-Dihydroxytryptamine">5,6-DHT</a></li>
<li><a href="5%2C6-MDO-DiPT" title="5,6-MDO-DiPT">5,6-MDO-DiPT</a></li>
<li><a href="5%2C6-MDO-DMT" title="5,6-MDO-DMT">5,6-MDO-DMT</a></li>
<li><a href="5%2C6-MDO-MiPT" title="5,6-MDO-MiPT">5,6-MDO-MiPT</a></li>
<li><a href="5%2C6-MeO-MiPT" title="5,6-MeO-MiPT">5,6-MeO-MiPT</a></li>
<li><a href="5%2C7-Dihydroxytryptamine" title="5,7-Dihydroxytryptamine">5,7-DHT</a></li>
<li><a href="Arachidonoyl_serotonin" title="Arachidonoyl serotonin">Arachidonoyl serotonin</a></li>
<li><a href="ASR-3001" title="ASR-3001">ASR-3001 (5-MeO-iPALT)</a></li>
<li>BAB</li>
<li><a href="Benanserin" title="Benanserin">Benanserin (BAS; SQ-4788)</a></li>
<li><a href="BGC20-761" title="BGC20-761">BGC20-761</a></li>
<li><a href="Bufotenidine" title="Bufotenidine">Bufotenidine (5-HTQ; <i>N</i>,<i>N</i>,<i>N</i>-TMS)</a></li>
<li><a href="Bufotenin" title="Bufotenin">Bufotenin (5-HO-DMT; <i>N</i>,<i>N</i>-DMS; mappine)</a></li>
<li><a href="Bufoviridine" title="Bufoviridine">Bufoviridine (5-SO-DMT)</a></li>
<li><a href="CP-132%2C484" title="CP-132,484">CP-132,484</a></li>
<li>Cqd 280</li>
<li>Cqd 285</li>
<li>Cqdd 280</li>
<li><a href="Donitriptan" title="Donitriptan">Donitriptan</a></li>
<li><a href="EMDT" title="EMDT">EMDT (2-Et-5-MeO-DMT)</a></li>
<li><a href="HIOC" title="HIOC">HIOC</a></li>
<li><a href="Indorenate" title="Indorenate">Indorenate (TR-3369)</a></li>
<li><a href="Isamide" title="Isamide">Isamide (<i>N</i>-CA-5-MT)</a></li>
<li><a href="L-741604" title="L-741604">L-741604</a></li>
<li><a href="MS-245" title="MS-245">MS-245</a></li>
<li><a href="N-DEAOP-5-MeO-NET" class="mw-redirect" title="N-DEAOP-5-MeO-NET"><i>N</i>-DEAOP-5-MeO-NET</a></li>
<li><a href="N-DEAOP-5-MeO-NMT" class="mw-redirect" title="N-DEAOP-5-MeO-NMT"><i>N</i>-DEAOP-5-MeO-NMT</a></li>
<li><a href="N-Feruloylserotonin" title="N-Feruloylserotonin"><i>N</i>-Feruloylserotonin (moschamine)</a></li>
<li><a href="Norbufotenin" class="mw-redirect" title="Norbufotenin">Norbufotenin (5-HO-NMT; NMS)</a></li>
<li><a href="O-Acetylbufotenine" title="O-Acetylbufotenine"><i>O</i>-Acetylbufotenine (5-AcO-DMT)</a></li>
<li><a href="O-Pivalylbufotenine" title="O-Pivalylbufotenine"><i>O</i>-Pivalylbufotenine (5-(<i>t</i>-BuCO)-DMT)</a></li>
<li><a href="Psilomethoxin" title="Psilomethoxin">Psilomethoxin (4-HO-5-MeO-DMT)</a></li>
<li><a href="Psilomethoxybin" class="mw-redirect" title="Psilomethoxybin">Psilomethoxybin (4-PO-5-MeO-DMT)</a></li>
<li><a href="Serotonin" title="Serotonin">Serotonin (5-HT)</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="N-Acetyltryptamine" title="N-Acetyltryptamine"><i>N</i>-Acetyltryptamines</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="2-Iodomelatonin" title="2-Iodomelatonin">2-Iodomelatonin</a></li>
<li>2-Phenylmelatonin</li>
<li>5-Methoxyluzindole</li>
<li>6-Chloromelatonin</li>
<li>6-Fluoromelatonin</li>
<li><a href="6-Hydroxymelatonin" title="6-Hydroxymelatonin">6-Hydroxymelatonin</a></li>
<li>6-Methoxymelatonin</li>
<li>6,7-Dichloro-2-methylmelatonin</li>
<li><a href="%CE%91-Methylmelatonin" title="Α-Methylmelatonin">α-Methylmelatonin</a></li>
<li><a href="Luzindole" title="Luzindole">Luzindole</a></li>
<li><a href="Melatonin" title="Melatonin">Melatonin (<i>N</i>-Ac-<i>O</i>-Me-serotonin; <i>N</i>-Ac-5-MeO-T)</a></li>
<li><a href="N-Acetylserotonin" title="N-Acetylserotonin">Normelatonin (<i>N</i>-acetylserotonin; NAS)</a></li>
<li><a href="N-Acetyltryptamine" title="N-Acetyltryptamine"><i>N</i>-Acetyltryptamine</a></li>
<li><i>N</i>-Butanoylmelatonin</li>
<li><i>N</i>-Propionylmelatonin</li>
<li><a href="Piromelatine" title="Piromelatine">Piromelatine</a></li>
<li><a href="TIK-301" title="TIK-301">TIK-301 (LY-156735)</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="%CE%91-Alkyltryptamine" class="mw-redirect" title="Α-Alkyltryptamine">α-Alkyltryptamines</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li>1-Methyl-AMT</li>
<li><a href="2%2C%CE%B1-Dimethyltryptamine" title="2,α-Dimethyltryptamine">2,α-DMT (2-Me-AMT)</a></li>
<li><a href="4-HO-%CE%B1MT" title="4-HO-αMT">4-HO-αMT (MP-14)</a></li>
<li><a href="4-Methyl-%CE%B1-ethyltryptamine" title="4-Methyl-α-ethyltryptamine">4-Methyl-αET</a></li>
<li><a href="4-Methyl-%CE%B1MT" class="mw-redirect" title="4-Methyl-αMT">4-Methyl-αMT (MP-809)</a></li>
<li><a href="5-Chloro-%CE%B1ET" title="5-Chloro-αET">5-Chloro-αET (PAL-526)</a></li>
<li><a href="5-Chloro-%CE%B1MT" title="5-Chloro-αMT">5-Chloro-αMT (PAL-542)</a></li>
<li><a href="5-Fluoro-AET" title="5-Fluoro-AET">5-Fluoro-αET (PAL-545)</a></li>
<li><a href="5-Fluoro-AMT" title="5-Fluoro-AMT">5-Fluoro-αMT (PAL-212; PAL-544)</a></li>
<li>5-Methyl-αET</li>
<li><a href="6-Fluoro-AMT" title="6-Fluoro-AMT">6-Fluoro-αMT</a></li>
<li><a href="7-Chloro-AMT" title="7-Chloro-AMT">7-Chloro-αMT</a></li>
<li><a href="7-Methyl-%CE%B1-ethyltryptamine" title="7-Methyl-α-ethyltryptamine">7-Me-αET</a></li>
<li><a href="%CE%91-Methyltryptophan" title="Α-Methyltryptophan">α-Methyltryptophan (αMTP)</a></li>
<li><a href="Alpha%2CN-DMT" class="mw-redirect" title="Alpha,N-DMT">α,<i>N</i>-DMT (<i>N</i>-Me-αMT; SKF-7024, Ro 3-1715)</a></li>
<li><a href="%CE%91%2CN%2CN-Trimethyltryptamine" title="Α,N,N-Trimethyltryptamine">α,<i>N</i>,<i>N</i>-TMT (α-Me-DMT; Alpha-N)</a></li>
<li><a href="%CE%91-Ethyltryptamine" title="Α-Ethyltryptamine">αET (etryptamine; Monase)</a></li>
<li><a href="%CE%91-Methyltryptamine" title="Α-Methyltryptamine">αMT (Indopan; IT-290; 3-API; 3-IT)</a></li>
<li><a href="Indolylpropylaminopentane" title="Indolylpropylaminopentane">IPAP (α,<i>N</i>-DPT)</a></li>
<li><a href="Soclenicant" title="Soclenicant">Soclenicant (BNC-210; Ile–Trp)</a></li></ul>
<ul><li><i>5-Hydroxy- and 5-alkoxy-α-alkyltryptamines:</i> <a href="1-Pr-5-MeO-AMT" class="mw-redirect" title="1-Pr-5-MeO-AMT">1-Pr-5-MeO-AMT</a></li>
<li><a href="5-Allyloxy-AMT" title="5-Allyloxy-AMT">5-Allyloxy-AMT</a></li>
<li><a href="5-Ethoxy-AMT" class="mw-redirect" title="5-Ethoxy-AMT">5-Ethoxy-αMT</a></li>
<li>5-iPrO-αMT</li>
<li><a href="5-MeO-AET" title="5-MeO-AET">5-MeO-αET</a></li>
<li><a href="5-MeO-AMT" title="5-MeO-AMT">5-MeO-αMT (α,<i>O</i>-DMS; Alpha-O)</a></li>
<li><a href="%CE%91-Methyl-5-hydroxytryptophan" title="Α-Methyl-5-hydroxytryptophan">α-Methyl-5-HTP</a></li>
<li><a href="%CE%91-Methylmelatonin" title="Α-Methylmelatonin">α-Methylmelatonin</a></li>
<li><a href="%CE%91-Methylserotonin" title="Α-Methylserotonin">α-Methylserotonin (5-HO-αMT; α-Me-5-HT)</a></li>
<li><a href="%CE%91%2CN%2CO-TMS" title="Α,N,O-TMS">α,<i>N</i>,<i>O</i>-TMS (5-MeO-α,<i>N</i>-DMT)</a></li>
<li><a href="%CE%91%2CN%2CN%2CO-TeMS" title="Α,N,N,O-TeMS">α,<i>N</i>,<i>N</i>,<i>O</i>-TeMS (5-MeO-α,<i>N</i>,<i>N</i>-TMT)</a></li>
<li><a href="AL-37350A" title="AL-37350A">AL-37350A (4,5-DHP-αMT)</a></li>
<li><a href="BW-723C86" title="BW-723C86">BW-723C86</a></li></ul>
<ul><li><i>β-Keto-α-alkyltryptamines:</i> <a href="BK-5Br-NM-AMT" title="BK-5Br-NM-AMT">BK-5Br-NM-AMT</a></li>
<li><a href="BK-5Cl-NM-AMT" title="BK-5Cl-NM-AMT">BK-5Cl-NM-AMT</a></li>
<li><a href="BK-5F-NM-AMT" title="BK-5F-NM-AMT">BK-5F-NM-AMT</a></li>
<li><a href="BK-NM-AMT" title="BK-NM-AMT">BK-NM-AMT</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="Cyclized_tryptamine" class="mw-redirect" title="Cyclized tryptamine">Cyclized tryptamines</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Barettin" title="Barettin">Barettin</a></li>
<li><a href="Cyclic_3-hydroxymelatonin" title="Cyclic 3-hydroxymelatonin">Cyclic 3-OHM</a></li>
<li><a href="Ergoline" title="Ergoline">Ergolines</a> and <a href="Lysergamide" class="mw-redirect" title="Lysergamide">lysergamides</a> (e.g., <a href="Lysergic_acid_diethylamide" class="mw-redirect" title="Lysergic acid diethylamide">LSD</a>)</li>
<li><a href="Harmala_alkaloid" title="Harmala alkaloid"><i>Harmala</i> alkaloids</a> and <a href="Substituted_%CE%B2-carboline" title="Substituted β-carboline">β-carbolines</a> (e.g., <a href="5-methoxyharmalan" class="mw-redirect" title="5-methoxyharmalan">5-methoxyharmalan</a>, <a href="6-MeO-THH" title="6-MeO-THH">6-MeO-THH</a>, <a href="6-methoxyharmalan" class="mw-redirect" title="6-methoxyharmalan">6-methoxyharmalan</a>, <a href="9-Methyl-%CE%B2-carboline" title="9-Methyl-β-carboline">9-Me-BC</a>, <a href="%CE%92-carboline" class="mw-redirect" title="Β-carboline">β-carboline (norharman)</a>, <a href="Fenharmane" title="Fenharmane">fenharmane</a>, <a href="Harmaline" title="Harmaline">harmaline</a>, <a href="Harmalol" title="Harmalol">harmalol</a>, <a href="Harmane" title="Harmane">harmane</a>, <a href="Harmine" title="Harmine">harmine</a>, <a href="LY-266%2C097" title="LY-266,097">LY-266,097</a>, <a href="Pinoline" title="Pinoline">pinoline</a>, <a href="Tetrahydroharmine" title="Tetrahydroharmine">tetrahydroharmine</a>, <a href="Tryptoline" title="Tryptoline">tryptoline</a>)</li>
<li><a href="Iboga-type_alkaloid" title="Iboga-type alkaloid"><i>Iboga</i> alkaloids</a> (e.g., <a href="Ibogaine" title="Ibogaine">ibogaine</a>, <a href="Ibogamine" title="Ibogamine">ibogamine</a>, <a href="Noribogaine" title="Noribogaine">noribogaine</a>, <a href="Tabernanthine" title="Tabernanthine">tabernanthine</a>)</li>
<li><a href="Ibogalog" title="Ibogalog">Ibogalogs</a> (e.g., <a href="Catharanthalog" title="Catharanthalog">catharanthalog</a>, fluorogainalog, <a href="Ibogainalog" title="Ibogainalog">ibogainalog</a>, <a href="Ibogaminalog" title="Ibogaminalog">ibogaminalog (DM-506)</a>, LS-22925, <a href="Noribogainalog" title="Noribogainalog">noribogainalog</a>, <a href="Noribogaminalog" title="Noribogaminalog">noribogaminalog</a>, <a href="PHA-57378" title="PHA-57378">PHA-57378</a>, <a href="PNU-22394" title="PNU-22394">PNU-22394</a>, <a href="Tabernanthalog" title="Tabernanthalog">tabernanthalog</a>)</li>
<li><a href="Imidazolylindole" title="Imidazolylindole">Imidazolylindoles</a> (e.g., <a href="AGH-107" title="AGH-107">AGH-107</a>, <a href="AGH-192" title="AGH-192">AGH-192</a>, <a href="AH-494" title="AH-494">AH-494</a>)</li>
<li><a href="Metralindole" title="Metralindole">Metralindole</a></li>
<li><a href="Partial_ergoline" class="mw-redirect" title="Partial ergoline">Partial ergolines and lysergamides</a> (e.g., <a href="NDTDI" title="NDTDI">NDTDI</a>, <a href="RU-27849" title="RU-27849">RU-27849</a>, <a href="RU-28251" title="RU-28251">RU-28251</a>, <a href="RU-28306" title="RU-28306">RU-28306</a>, <a href="FHATHBIN" title="FHATHBIN">FHATHBIN</a>, <a href="LY-178210" title="LY-178210">LY-178210</a>, <a href="Bay_R_1531" title="Bay R 1531">Bay R 1531 (LY-197206)</a>, <a href="LY-293284" title="LY-293284">LY-293284</a>, <a href="10%2C11-seco-LSD" class="mw-redirect" title="10,11-seco-LSD">10,11-seco-LSD</a>, <a href="10%2C11-secoergoline" class="mw-redirect" title="10,11-secoergoline">10,11-secoergoline (α,<i>N</i>-Pip-T)</a>, <a href="CT-5252" title="CT-5252">CT-5252</a>)</li>
<li><a href="Pertine" title="Pertine">Pertines</a> (e.g., <a href="Alpertine" title="Alpertine">alpertine</a>, <a href="Milipertine" title="Milipertine">milipertine</a>, <a href="Oxypertine" title="Oxypertine">oxypertine</a>, <a href="Solypertine" title="Solypertine">solypertine</a>)</li>
<li><a href="Piperidinylethylindole" class="mw-redirect" title="Piperidinylethylindole">Piperidinylethylindoles</a> (e.g., <a href="Pip-Tryptamine" title="Pip-Tryptamine">pip-T</a>, indolylethylfentanyl)</li>
<li><a href="Pyrrolidinylethylindole" title="Pyrrolidinylethylindole">Pyrrolidinylethylindoles</a> (e.g., <a href="Pyr-T" title="Pyr-T">pyr-T</a>, <a href="4-HO-pyr-T" title="4-HO-pyr-T">4-HO-pyr-T</a>, <a href="5-MeO-pyr-T" title="5-MeO-pyr-T">5-MeO-pyr-T</a>, <a href="4-Fluoro-5-MeO-pyr-T" class="mw-redirect" title="4-Fluoro-5-MeO-pyr-T">4-F-5-MeO-pyr-T</a>)</li>
<li><a href="Pyrrolidinylmethylindole" title="Pyrrolidinylmethylindole">Pyrrolidinylmethylindoles</a> (e.g., <a href="MPMI_(drug)" title="MPMI (drug)">MPMI</a>, <a href="4-HO-MPMI" title="4-HO-MPMI">4-HO-MPMI (lucigenol)</a>, <a href="5F-MPMI" title="5F-MPMI">5F-MPMI</a>, <a href="5-MeO-MPMI" title="5-MeO-MPMI">5-MeO-MPMI</a>, <a href="CP-122288" title="CP-122288">CP-122288</a>, <a href="CP-135807" title="CP-135807">CP-135807</a>, <a href="Eletriptan" title="Eletriptan">eletriptan</a>)</li>
<li><a href="Tetrahydrocarbazolamine" title="Tetrahydrocarbazolamine">Tetrahydrocarbazolamines</a> (e.g., <a href="Ciclindole" title="Ciclindole">ciclindole</a>, <a href="Flucindole" title="Flucindole">flucindole</a>, <a href="Frovatriptan" title="Frovatriptan">frovatriptan</a>, <a href="LY-344864" title="LY-344864">LY-344864</a>, <a href="Ramatroban" title="Ramatroban">ramatroban</a>)</li>
<li><a href="Tetrahydropyridinylindole" title="Tetrahydropyridinylindole">Tetrahydropyridinylindoles</a> (e.g., <a href="RS134-49" title="RS134-49">RS134-49</a>, <a href="RU-28253" title="RU-28253">RU-28253</a>)</li>
<li><a href="Tetrahydropyrroloquinoline" class="mw-redirect" title="Tetrahydropyrroloquinoline">Tetrahydropyrroloquinolines</a> (e.g., <a href="Bufothionine" title="Bufothionine">bufothionine</a>, <a href="O-methylnordehydrobufotenine" class="mw-redirect" title="O-methylnordehydrobufotenine"><i>O</i>-methylnordehydrobufotenine</a>)</li>
<li><a href="Yohimban" title="Yohimban">Yohimbans</a> (e.g., <a href="Yohimbine" title="Yohimbine">yohimbine</a>, <a href="Rauwolscine" title="Rauwolscine">rauwolscine</a>, <a href="Spegatrine" title="Spegatrine">spegatrine</a>, <a href="Corynanthine" title="Corynanthine">corynanthine</a>, <a href="Ajmalicine" title="Ajmalicine">ajmalicine</a>, <a href="Reserpine" title="Reserpine">reserpine</a>, <a href="Deserpidine" title="Deserpidine">deserpidine</a>, <a href="Rescinnamine" title="Rescinnamine">rescinnamine</a>)</li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="Substituted_isotryptamine" title="Substituted isotryptamine">Isotryptamines</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="5-MeO-isoDMT" title="5-MeO-isoDMT">5-MeO-isoDMT</a></li>
<li><a href="6-MeO-isoDMT" title="6-MeO-isoDMT">6-MeO-isoDMT</a></li>
<li><a href="IsoAMT" class="mw-redirect" title="IsoAMT">isoAMT (1-API; 1-IT; α-Me-isoT)</a></li>
<li><a href="IsoDMT" title="IsoDMT">isoDMT</a></li>
<li><a href="Isotryptamine" title="Isotryptamine">Isotryptamine (isoT)</a></li>
<li><a href="Ro60-0175" title="Ro60-0175">Ro60-0175</a></li>
<li><a href="VER-3323" title="VER-3323">VER-3323</a></li>
<li><a href="Zalsupindole" title="Zalsupindole">Zalsupindole (DLX-001, AAZ-A-154)</a></li></ul>
<ul><li><i>Cyclized isotryptamines:</i> <a href="JRT_(drug)" title="JRT (drug)">JRT</a></li>
<li><a href="PNU-181731" title="PNU-181731">PNU-181731</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Related compounds</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li>2-Azapsilocin</li>
<li>4-Aza-5-MeO-DPT</li>
<li>5-Aza-4-MeO-DiPT</li>
<li><a href="5-Hydroxyindoleacetic_acid" title="5-Hydroxyindoleacetic acid">5-HIAA</a></li>
<li><a href="5-Hydroxyindoleacetaldehyde" title="5-Hydroxyindoleacetaldehyde">5-HIAL</a></li>
<li>5-HITCA</li>
<li>5-MIAL</li>
<li>7-Aza-5-MeO-DiPT</li>
<li>α-Carboline</li>
<li><a href="%CE%93-Carboline" title="Γ-Carboline">γ-Carbolines</a> (pyridoindoles) (e.g., <a href="%CE%93-carboline" class="mw-redirect" title="Γ-carboline">γ-carboline</a>, <a href="Alosetron" title="Alosetron">alosetron</a>, <a href="Gevotroline" title="Gevotroline">gevotroline</a>, <a href="Latrepirdine" title="Latrepirdine">latrepirdine</a>, <a href="Lurosetron" title="Lurosetron">lurosetron</a>, <a href="Mebhydrolin" title="Mebhydrolin">mebhydrolin</a>, <a href="Tiflucarbine" title="Tiflucarbine">tiflucarbine</a>)</li>
<li><a href="Amedalin" title="Amedalin">Amedalin</a></li>
<li>Benzindopyrine</li>
<li><a href="Substituted_benzofuran" title="Substituted benzofuran">Benzofurans</a> (e.g., <a href="3-(2-aminopropyl)benzofuran" class="mw-redirect" title="3-(2-aminopropyl)benzofuran">3-APB</a>, <a href="5-MeO-DiBF" title="5-MeO-DiBF">5-MeO-DiBF</a>, <a href="Benzofuranylpropylaminopentane" title="Benzofuranylpropylaminopentane">BPAP</a>, <a href="3-F-BPAP" title="3-F-BPAP">3-F-BPAP</a>, <a href="Dimemebfe" title="Dimemebfe">dimemebfe</a>, <a href="Mebfap" title="Mebfap">mebfap</a>, <a href="Oxa-noribogaine" title="Oxa-noribogaine">oxa-noribogaine</a>)</li>
<li><a href="Substituted_benzothiophene" title="Substituted benzothiophene">Benzothiophenes</a> (e.g., <a href="3-APBT" title="3-APBT">3-APBT</a>)</li>
<li><a href="Carmoxirole" title="Carmoxirole">Carmoxirole</a></li>
<li>CT-4436</li>
<li><a href="Daledalin" title="Daledalin">Daledalin</a></li>
<li><a href="Gramine" title="Gramine">Gramine</a></li>
<li><a href="Histamine" title="Histamine">Histamine</a></li>
<li>I-32</li>
<li><a href="Indoleacetaldehyde" class="mw-redirect" title="Indoleacetaldehyde">IAL</a></li>
<li>IN-399</li>
<li><a href="Indazolethylamine" title="Indazolethylamine">Indazolethylamines</a> (e.g., <a href="AL-34662" title="AL-34662">AL-34662</a>, <a href="AL-38022A" title="AL-38022A">AL-38022A</a>, <a href="O-methyl-AL-34662" class="mw-redirect" title="O-methyl-AL-34662"><i>O</i>-methyl-AL-34662</a>, <a href="VU6067416" title="VU6067416">VU6067416</a>, <a href="YM-348" title="YM-348">YM-348</a>)</li>
<li><a href="Indenylethylamine" class="mw-redirect" title="Indenylethylamine">Indenylethylamines</a> (e.g., <a href="C-DMT" title="C-DMT">C-DMT</a>)</li>
<li><a href="Indolizinylethylamine" title="Indolizinylethylamine">Indolizinylethylamines</a> (e.g., <a href="TACT908" title="TACT908">TACT908 (2ZEDMA)</a>, <a href="1ZP2MA" title="1ZP2MA">1ZP2MA</a>, <a href="1Z2MAP1O" title="1Z2MAP1O">1Z2MAP1O</a>)</li>
<li><a href="Indolylaminopropane" class="mw-redirect" title="Indolylaminopropane">Indolylaminopropanes</a> (e.g., 1-API, 2-API, 4-API, <a href="5-API" class="mw-redirect" title="5-API">5-API (5-IT; PAL-571)</a>, <a href="6-API" class="mw-redirect" title="6-API">6-API (6-IT)</a>, 7-API)</li>
<li><a href="Iprindole" title="Iprindole">Iprindole</a></li>
<li><a href="Masupirdine" title="Masupirdine">Masupirdine</a></li>
<li>Medmain</li>
<li><a href="Molindone" title="Molindone">Molindone</a></li>
<li>Non-tryptamine <a href="Triptan" title="Triptan">triptans</a> (e.g., <a href="Avitriptan" title="Avitriptan">avitriptan</a>, <a href="LY-334370" title="LY-334370">LY-334370</a>, <a href="Naratriptan" title="Naratriptan">naratriptan</a>)</li>
<li><a href="Ondansetron" title="Ondansetron">Ondansetron</a></li>
<li><a href="Oxazinopyridoindole" class="mw-redirect" title="Oxazinopyridoindole">Oxazinopyridoindoles</a> (e.g., <a href="IHCH-8134" title="IHCH-8134">IHCH-8134</a>)</li>
<li><a href="Substituted_phenethylamine" title="Substituted phenethylamine">Phenethylamines</a> (e.g., <a href="Phenethylamine" title="Phenethylamine">phenethylamine</a>, <a href="Amphetamine" title="Amphetamine">amphetamine</a>)</li>
<li><a href="Piperidinylindole" title="Piperidinylindole">Piperidinylindoles</a> (e.g., <a href="BRL-54443" title="BRL-54443">BRL-54443</a>, <a href="LY-334370" title="LY-334370">LY-334370</a>, <a href="Naratriptan" title="Naratriptan">naratriptan</a>, <a href="Sertindole" title="Sertindole">sertindole</a>, <a href="SN-22" title="SN-22">SN-22</a>)</li>
<li><a href="Pirlindole" title="Pirlindole">Pirlindole</a></li>
<li><a href="Pyridinylindole" class="mw-redirect" title="Pyridinylindole">Pyridinylindoles</a> (e.g., <a href="Tepirindole" title="Tepirindole">tepirindole</a>)</li>
<li><a href="Pyridopyrroloquinoxaline" title="Pyridopyrroloquinoxaline">Pyridopyrroloquinoxalines</a> (e.g., <a href="IHCH-7113" title="IHCH-7113">IHCH-7113</a>, <a href="IHCH-7079" title="IHCH-7079">IHCH-7079</a>, <a href="IHCH-7086" title="IHCH-7086">IHCH-7086</a>, <a href="Lumateperone" title="Lumateperone">lumateperone</a>, <a href="Deulumateperone" title="Deulumateperone">deulumateperone</a>, <a href="ITI-1549" title="ITI-1549">ITI-1549</a>)</li>
<li><a href="Pyrrolylethylamine" title="Pyrrolylethylamine">Pyrrolylethylamines</a> (e.g., <a href="2-pyrrolylethylamine" class="mw-redirect" title="2-pyrrolylethylamine">2-pyrrolylethylamine (NEA)</a>, <a href="3-pyrrolylethylamine" class="mw-redirect" title="3-pyrrolylethylamine">3-pyrrolylethylamine (3-NEA)</a>, <a href="3-pyrrolylpropylamine" class="mw-redirect" title="3-pyrrolylpropylamine">3-pyrrolylpropylamine</a>)</li>
<li><a href="Pyrrolopyridinylethylamine" class="mw-redirect" title="Pyrrolopyridinylethylamine">Pyrrolopyridinylethylamines</a> (e.g., <a href="WAY-208466" title="WAY-208466">WAY-208466</a>)</li>
<li><a href="Quinolinylethylamine" class="mw-redirect" title="Quinolinylethylamine">Quinolinylethylamines</a> (e.g., <a href="Mefloquine" title="Mefloquine">mefloquine</a>)</li>
<li><a href="Ro60-0213" title="Ro60-0213">Ro60-0213</a></li>
<li><a href="Selisistat" title="Selisistat">Selisistat</a></li>
<li><a href="Tetrahydropyridinylindole" title="Tetrahydropyridinylindole">Tetrahydropyridinylindoles</a> (e.g., <a href="EMD-386088" title="EMD-386088">EMD-386088</a>, <a href="LY-367%2C265" title="LY-367,265">LY-367265</a>, <a href="RU-24%2C969" class="mw-redirect" title="RU-24,969">RU-24,969</a>)</li>
<li><a href="Tetrahydropyridinylpyrrolopyridine" title="Tetrahydropyridinylpyrrolopyridine">Tetrahydropyridinylpyrrolopyridines</a> (e.g., <a href="(R)-69" title="(R)-69">(<i>R</i>)-69 (3IQ)</a>, (<i>R</i>)-70, <a href="CP-94253" title="CP-94253">CP-94253</a>)</li>
<li><a href="Tetrindole" title="Tetrindole">Tetrindole</a></li>
<li><a href="Tipindole" title="Tipindole">Tipindole</a></li>
<li><a href="Zilpaterol" title="Zilpaterol">Zilpaterol (RU-42173)</a></li></ul>
</div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div>
<ul><li><i><b>See also:</b> Phenethylamines</i></li>
<li><i>Ergolines and lysergamides</i></li>
<li><i>Psychedelics</i></li></ul>
</div></td></tr></tbody></table></div>
<div class="navbox-styles"></div><div role="navigation" class="navbox" aria-labelledby="AstraZeneca299" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="AstraZeneca299" style="font-size:114%;margin:0 4em"><a href="AstraZeneca" title="AstraZeneca">AstraZeneca</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Products</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Acalabrutinib" title="Acalabrutinib">Acalabrutinib</a></li>
<li><a href="Anastrozole" title="Anastrozole">Anastrozole</a></li>
<li><a href="Andexanet_alfa" title="Andexanet alfa">Andexanet alfa</a></li>
<li><a href="Anifrolumab" title="Anifrolumab">Anifrolumab</a></li>
<li><a href="Asfotase_alfa" title="Asfotase alfa">Asfotase alfa</a></li>
<li><a href="Atenolol" title="Atenolol">Atenolol</a></li>
<li><a href="Benralizumab" title="Benralizumab">Benralizumab</a></li>
<li><a href="Bicalutamide" title="Bicalutamide">Bicalutamide</a></li>
<li><a href="Brompheniramine" title="Brompheniramine">Brompheniramine</a></li>
<li><a href="Budesonide" title="Budesonide">Budesonide</a></li>
<li><a href="Budesonide/formoterol" title="Budesonide/formoterol">Budesonide/formoterol</a></li>
<li><a href="Budesonide/glycopyrronium_bromide/formoterol" title="Budesonide/glycopyrronium bromide/formoterol">Budesonide/glycopyrronium bromide/formoterol</a></li>
<li><a href="Candesartan" title="Candesartan">Candesartan</a></li>
<li><a href="Dapagliflozin" title="Dapagliflozin">Dapagliflozin</a></li>
<li><a href="Disufenton_sodium" title="Disufenton sodium">Disufenton sodium</a></li>
<li><a href="Durvalumab" title="Durvalumab">Durvalumab</a></li>
<li><a href="Eculizumab" title="Eculizumab">Eculizumab</a></li>
<li><a href="Esomeprazole" title="Esomeprazole">Esomeprazole</a></li>
<li><a href="Exenatide" title="Exenatide">Exenatide</a></li>
<li><a href="Live_attenuated_influenza_vaccine" title="Live attenuated influenza vaccine">FluMist</a></li>
<li><a href="Fulvestrant" title="Fulvestrant">Fulvestrant</a></li>
<li><a href="Gefitinib" title="Gefitinib">Gefitinib</a></li>
<li><a href="Glycopyrronium_bromide/formoterol" title="Glycopyrronium bromide/formoterol">Glycopyrronium bromide/formoterol</a></li>
<li><a href="Goserelin" title="Goserelin">Goserelin</a></li>
<li><a href="Isosorbide_mononitrate" title="Isosorbide mononitrate">Isosorbide mononitrate</a></li>
<li><a href="Metoprolol" title="Metoprolol">Metoprolol</a></li>
<li><a href="Motavizumab" title="Motavizumab">Motavizumab</a></li>
<li><a href="Olaparib" title="Olaparib">Olaparib</a></li>
<li><a href="Omeprazole" title="Omeprazole">Omeprazole</a></li>
<li><a href="Osimertinib" title="Osimertinib">Osimertinib</a></li>
<li><a href="Palivizumab" title="Palivizumab">Palivizumab</a></li>
<li><a href="Propofol" title="Propofol">Propofol</a></li>
<li><a href="Quetiapine" title="Quetiapine">Quetiapine</a></li>
<li><a href="Ravulizumab" title="Ravulizumab">Ravulizumab</a></li>
<li><a href="Roflumilast" title="Roflumilast">Roflumilast</a></li>
<li><a href="Rosuvastatin" title="Rosuvastatin">Rosuvastatin</a></li>
<li><a href="Roxadustat" title="Roxadustat">Roxadustat</a></li>
<li><a href="Salbutamol/budesonide" title="Salbutamol/budesonide">Salbutamol/budesonide</a></li>
<li><a href="Savolitinib" title="Savolitinib">Savolitinib</a></li>
<li><a href="Saxagliptin" title="Saxagliptin">Saxagliptin</a></li>
<li><a href="Sebelipase_alfa" title="Sebelipase alfa">Sebelipase alfa</a></li>
<li><a href="Selumetinib" title="Selumetinib">Selumetinib</a></li>
<li><a href="Sodium_zirconium_cyclosilicate" title="Sodium zirconium cyclosilicate">Sodium zirconium cyclosilicate</a></li>
<li><a href="Tamoxifen" title="Tamoxifen">Tamoxifen</a></li>
<li><a href="Ticagrelor" title="Ticagrelor">Ticagrelor</a></li>
<li><a href="Tixagevimab/cilgavimab" title="Tixagevimab/cilgavimab">Tixagevimab/cilgavimab</a></li>
<li><a href="Trastuzumab_deruxtecan" title="Trastuzumab deruxtecan">Trastuzumab deruxtecan</a></li>
<li><a href="Vandetanib" title="Vandetanib">Vandetanib</a></li>
<li><a href="Oxford%E2%80%93AstraZeneca_COVID-19_vaccine" title="Oxford–AstraZeneca COVID-19 vaccine">Vaxzevria</a></li>
<li><a href="Ximelagatran" title="Ximelagatran">Ximelagatran</a></li>
<li><a href="Zafirlukast" title="Zafirlukast">Zafirlukast</a></li>
</ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Predecessors and<br>acquired companies</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Astra_AB" title="Astra AB">Astra AB</a></li>
<li><a href="Alexion_Pharmaceuticals" title="Alexion Pharmaceuticals">Alexion Pharmaceuticals</a></li>
<li><a href="Cambridge_Antibody_Technology" title="Cambridge Antibody Technology">Cambridge Antibody Technology</a></li>
<li><a href="MedImmune" title="MedImmune">MedImmune</a></li>
<li><a href="Zeneca" title="Zeneca">Zeneca</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">People</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Tom_McKillop" title="Tom McKillop">Tom McKillop</a></li>
<li><a href="Louis_Schweitzer_(CEO)" class="mw-redirect" title="Louis Schweitzer (CEO)">Louis Schweitzer</a></li></ul>
</div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="font-weight: bold;"><div>
<ul><li><span class="noviewer" typeof="mw:File"><span title="Category"></span></span> Category</li>
<li><span class="noviewer" typeof="mw:File"><span title="Commons page"></span></span> <a href="https://commons.wikimedia.org/wiki/Category:AstraZeneca" class="extiw external" title="commons:Category:AstraZeneca">Commons</a></li></ul>
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